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HEALTH CONSULTATION

Evaluation of Health Impacts from Potential Past Exposure to
Tetrachloroethylene in the Natick Public Water Supply

Prepared in relation to the

NATICK LABORATORY ARMY RESEARCH
(a/k/a U.S. ARMY SOLDIER SYSTEM COMMAND (SSCOM) - NATICK)
NATICK, MIDDLESEX COUNTY, MASSACHUSETTS
CERCLIS NO. MA1210020631

March 10, 1998

Prepared by:

Federal Facilities Assessment Branch
Division of Health Assessment and Consultation


TABLE OF CONTENTS

LIST OF TABLES

LIST OF FIGURES

LIST OF ACRONYMS AND ABBREVIATIONS

BACKGROUND AND STATEMENT OF ISSUES

    Background
    Statement of Issues

SUMMARY

DISCUSSION

    Exposure
    Pharmacokinetics
    Outcomes of Concern
    Reproductive and Developmental Toxicity
      Animal Studies
        Oral Exposure
        Inhalation Exposure
      Human Health Studies
        Oral Exposure
        Inhalation Exposure
      Summary
    Nervous System Toxicity
      Animal Studies
        Oral Exposure
        Inhalation Exposure
      Human Health Studies
        Oral Exposure
        Inhalation Exposure
      Summary
    Cancer
      Animal Studies
        Oral Exposure
        Inhalation Exposure
      Human Health Studies
        Oral Exposure
        Inhalation Exposure
      Summary

CONCLUSIONS AND RECOMMENDATIONS

PREPARERS AND REVIEWERS OF REPORT

REFERENCES

APPENDIX A

    Estimation of Daily Exposure Dose for Ingestion of PCE Water
    Estimation of Daily Exposure Dose for Inhalation of Contaminants in Air
    Tables

APPENDIX B - Figures

APPENDIX C - Glossary of Terms

APPENDIX D - Response to Public Comments


LIST OF TABLES
(in Appendix A)

Table A-1: Estimation of Daily Human Exposure Dose for Ingestion of PCE in Water

Table A-2: Estimation of Daily Human Exposure Dose for Inhalation of Contaminants in Air

Table A-3: Summary of Animal Studies -- Oral Exposure

Table A-4: Summary of Animal Studies -- Inhalation Exposure

Table A-5: Summary of Human Health Studies -- Oral and Inhalation Exposure


LIST OF FIGURES
(in Appendix B)

Figure 1: Location of Census Tracts in Natick, Massachusetts (source: MDPH, 1997b)


LIST OF ABBREVIATIONS

ATSDR Agency for Toxic Substances and Disease Registry
ACGIH American Conference of Governmental Industrial Hygienists
CNS Central Nervous System
Conc (or conc) concentration
dL deciliter
dy day
EPA Environmental Protection Agency
Gd Gestational day
hr hour
kg kilogram
LBW Low birthweight
LOAEL Lowest-Observed-Adverse-Effect-Level
MBW Mean birth weight
MCL Maximum Contaminant Level
mg/kg milligram per kilogram
mg/kg/day milligrams per kilogram per day (equivalent to mg/kg/d)
µg/L or µg/kg microgram per liter or microgram per kilogram
mg/m3 milligrams per meter cubed
MRL Minimal Risk Level
NCI National Cancer Institute
ND Non-detect
NOAEL No-Observed-Adverse-Effect-Level
NPL National Priorities List
NTD Neural tube defect
OR Odds ratio
PB/PK Physiologically-Based/Pharmacokinetic (model)
PCE Perchloroethylene or tetrachloroethylene
PHA Public Health Assessment
ppb parts per billion (equivalent to µg/L or µg/kg)
ppm parts per million (equivalent to mg/kg or µg/ml)
RAB Restoration Advisory Board
SEER Surveillance Epidemiology End Result
SGA Small for gestational age
SIR Standardized incidence rate
SCE Sister chromatid exchange
SMR Standardized mortality ratio
TCE Trichloroethylene
TCA Trichloroacetic acid
TLV Threshold Limit Value
VLBW Very low birthweight
VOCs Volatile organic compounds
wk week


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