HEALTH CONSULTATION
Evaluation of Health Impacts from Potential Past Exposure to
Tetrachloroethylene in the Natick Public Water Supply
Prepared in relation to the
NATICK LABORATORY ARMY RESEARCH
(a/k/a U.S. ARMY SOLDIER SYSTEM COMMAND (SSCOM) - NATICK)
NATICK, MIDDLESEX COUNTY, MASSACHUSETTS
CERCLIS NO. MA1210020631
March 10, 1998
Prepared by:
Federal Facilities Assessment Branch
Division of Health Assessment and Consultation
TABLE OF CONTENTS
LIST OF ACRONYMS AND ABBREVIATIONS
BACKGROUND AND STATEMENT OF ISSUES
- Exposure
Pharmacokinetics
Outcomes of Concern
Reproductive and Developmental Toxicity Nervous System Toxicity Cancer
CONCLUSIONS AND RECOMMENDATIONS
PREPARERS AND REVIEWERS OF REPORT
- Estimation of Daily Exposure Dose for Ingestion of PCE Water
Estimation of Daily Exposure Dose for Inhalation of Contaminants in Air
Tables
APPENDIX C - Glossary of Terms
APPENDIX D - Response to Public Comments
LIST OF TABLES
(in Appendix A)
Table A-1: Estimation of Daily Human Exposure Dose for Ingestion of PCE in Water
Table A-2: Estimation of Daily Human Exposure Dose for Inhalation of Contaminants in Air
Table A-3: Summary of Animal Studies -- Oral Exposure
Table A-4: Summary of Animal Studies -- Inhalation Exposure
Table A-5: Summary of Human Health Studies -- Oral and Inhalation Exposure
LIST OF FIGURES
(in Appendix B)
Figure 1: Location of Census Tracts in Natick, Massachusetts (source: MDPH, 1997b)
| ATSDR | Agency for Toxic Substances and Disease Registry |
| ACGIH | American Conference of Governmental Industrial Hygienists |
| CNS | Central Nervous System |
| Conc (or conc) | concentration |
| dL | deciliter |
| dy | day |
| EPA | Environmental Protection Agency |
| Gd | Gestational day |
| hr | hour |
| kg | kilogram |
| LBW | Low birthweight |
| LOAEL | Lowest-Observed-Adverse-Effect-Level |
| MBW | Mean birth weight |
| MCL | Maximum Contaminant Level |
| mg/kg | milligram per kilogram |
| mg/kg/day | milligrams per kilogram per day (equivalent to mg/kg/d) |
| µg/L or µg/kg | microgram per liter or microgram per kilogram |
| mg/m3 | milligrams per meter cubed |
| MRL | Minimal Risk Level |
| NCI | National Cancer Institute |
| ND | Non-detect |
| NOAEL | No-Observed-Adverse-Effect-Level |
| NPL | National Priorities List |
| NTD | Neural tube defect |
| OR | Odds ratio |
| PB/PK | Physiologically-Based/Pharmacokinetic (model) |
| PCE | Perchloroethylene or tetrachloroethylene |
| PHA | Public Health Assessment |
| ppb | parts per billion (equivalent to µg/L or µg/kg) |
| ppm | parts per million (equivalent to mg/kg or µg/ml) |
| RAB | Restoration Advisory Board |
| SEER | Surveillance Epidemiology End Result |
| SGA | Small for gestational age |
| SIR | Standardized incidence rate |
| SCE | Sister chromatid exchange |
| SMR | Standardized mortality ratio |
| TCE | Trichloroethylene |
| TCA | Trichloroacetic acid |
| TLV | Threshold Limit Value |
| VLBW | Very low birthweight |
| VOCs | Volatile organic compounds |
| wk | week |
