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PETITIONED PUBLIC HEALTH ASSESSMENT

AMERICAN CHEMICAL SERVICES INC.
GRIFFITH, LAKE COUNTY, INDIANA



ENVIRONMENTAL CONTAMINATION AND OTHER HAZARDS

The tables in this section list the contaminants of concern. Those contaminants are evaluated in subsequent sections of this public health assessment to determine whether human exposure to them is of public health concern. ATSDR selects and discusses contaminants based upon the following factors:

The tables that follow under the On-site Contamination and Off-site Contamination subsections list contaminants of concern. Human exposure to contaminants listed may not necessarily result in adverse health effects. Instead, the list indicates contaminants that will be evaluated further in this public health assessment.

Comparison values for this public health assessment are contaminant concentrations in specific media used to select contaminants for further evaluation. Those values include Environmental Media Evaluation Guides (EMEGs), Cancer Risk Evaluation Guides (CREGs), and other relevant guidelines. CREGs are estimated contaminant concentrations based on the expected occurrence of one excess cancer in a million persons exposed over a lifetime. CREGs are calculated from EPA's cancer slope factors. EPA's Proposed Maximum Contaminant Levels (PMCLs) are Maximum Contaminant Levels (MCLs) proposed for adoption by EPA. The MCL represents contaminant concentrations that EPA deems protective of public health (considering the availability and economics of water treatment technology) over a lifetime (70 years) at an exposure rate of 2 liters water per day. The MCLs are regulatory concentrations. EPA's Reference Doses (RfDs) are estimates of the levels of daily exposure to contaminants unlikely to cause adverse health effects.

A. ON-SITE CONTAMINATION

Contaminants of concern in each medium at the ACS site are listed in Tables 1 - 4. All analytical results in this subsection were collected by Warzyn Engineering during the RI process from July 1989 through August 1990 (1) and during additional sampling in January 1991 and August 1991.

Waste Material and Subsurface Soil

Organic chemical (e.g., trichloroethene and benzene) contamination was found in the waste material and subsurface soil (greater than one foot) samples at similar levels at the On-Site Containment, Still Bottoms, Treatment Lagoon #1, Fire Pond, and Off-Site Containment areas (Table 1). Except for polychlorinated biphenyls (PCBs), much lower organic chemical contamination was found at the Kapica/Pazmey area. The maximum concentration of PCBs was detected in waste material; the Off-site Containment area contained the highest concentration of PCBs in soil. The Kapica/Pazmey area soil contained concentrations of PCBs ranging from 0 - 27 mg/Kg at depths of 0 - 1 foot and from 0 - 42 mg/Kg at depths of 3 - 4.5 feet. The highest concentration of metals (lead, barium, and cadmium) in the soil was found at the Kapica/Pazmey area. Subsurface soil samples collected at depths of 3 feet in the Kapica/Pazmey area contained concentrations of

TABLE 1

RANGE OF CONTAMINANT CONCENTRATIONS IN
ON-SITE WASTE MATERIAL AND SUBSURFACE SOIL


CONTAMINANT

CONCENTRATION RANGE
(mg/kg)
COMPARISON VALUE
(mg/kg) Source

WASTE MATERIAL

     
       

Trichloroethene

<0.005-1,700 1 RfD
Benzene <0.005-7,100 2 CREG
Tetrachloroethene <0.005-5,900 500 RfD
Xylene (Total) <0.005-25,000 100,000 RfD
Carbon Tetrachloride <0.005-3,600 35 RfD
1,1,2-Trichloroethane <0.005-320 12 CREG
Naphthalene <0.33-2,400 200 RfD
1,1,1-Trichloroethane <0.005-20,000 4,500 RfD
Toluene <0.005-200,000 10,000 RfD
Polychlorinated biphenyls (PCBs) <0.08-400 0.09 CREG
Lead <0.005-16,200 *  

Barium

<42-1,560 3,500 RfD
       

SUBSURFACE SOIL

     
       

Tetrachloroethene

<0.005-46,000 500 RfD
Trichloroethene <0.005-19,000 1 RfD
Benzene <0.005-46,000 2 CREG
Chloroform <0.005-2,800 20 EMEG
Methyl Isobutyl Ketone <0.01-2,500 2,500 RfD
Vinyl Chloride <0.01-160 2 EMEG
1,1,1-Trichloroethane <0.005-150,000 4,500 RfD
1,1,2-Trichloroethane <0.005-400 12 CREG
Xylene (Total) <0.005-100,000 100,000 RfD
Methyl Ethyl Ketone <0.01-99,000 2,500 RfD
PCB <0.08-250 0.09 CREG
Lead <0.005-17,200 *  

Barium

<42-1,780 3,500 RfD
Cadmium <0.1-1,700 1 EMEG

NOTE:

mg/kg - milligrams per kilogram (ppm - parts per million)
CREG - Cancer Risk Evaluation Guide
EMEG - Environmental Media Evaluation Guide
RfD - Reference Dose
* - No Comparison Value

Source: Warzyn Engineering, Inc. Draft Remedial Investigation Report, ACS NPL Site, Griffith, Indiana. Chicago, Illinois: Warzyn Engineering, Inc., 1990 .


lead ranging from 5,810 - 10,700 mg/kg. The next highest levels of metals contamination in soil were found at the Still Bottom area (1). No waste material or subsurface soil samples were taken at the Griffith Municipal Landfill (1).

Surface Soil

Surface soil (0-3 inches) samples were not collected during the RI process. All of the waste material at the On-Site Containment, Still Bottoms, Treatment Lagoon #1, Fire Pond, and Off-Site Containment areas are covered with several feet of clean soil (1). Therefore, it is not necessary to sample surface soils at those locations. However, waste liquids and rinse water from drums were discarded directly onto the Kapica/Pazmey surface soils. Surface soil samples from that area would have been useful to determine PCB and metal concentrations in the top soil. That type of data is needed because people are more likely to contact surface than subsurface soils.

Leachate

Leachate samples were taken at the Griffith Municipal Landfill. Analysis of the samples showed elevated levels of organic chemicals and metals originating from the landfill (Table 2) (1).

TABLE 2

RANGE OF CONTAMINANT CONCENTRATIONS IN ON-SITE LEACHATE


CONTAMINANT

CONCENTRATION RANGE
(mg/L)
COMPARISON VALUE
(mg/L) Source

Benzene

<0.005-0.006 0.001 CREG

Methyl Ethyl Ketone

<0.005-0.83 2 RfD

Barium

<0.005-2.37 0.7 RfD

Lead

<0.005-1.37 0.005 PMCL
Manganese <0.005-9.3 1 RfD
Chromium (Total) <0.005-0.288 0.05 EMEG
Mercury <0.0002-0.00098 0.003 RfD

NOTE:

mg/L - milligrams per liter (ppm - parts per million)
CREG - Cancer Risk Evaluation Guide
EMEG - Environmental Media Evaluation Guide
RfD - Reference Dose
PMCL - Proposed Maximum Contaminant Level

Source: Warzyn Engineering, Inc. Draft Remedial Investigation Report, ACS NPL Site, Griffith, Indiana. Chicago, Illinois: Warzyn Engineering, Inc., 1990.

Surface Water and Sediment

Surface water and sediment samples were taken in the marshlands surrounding the ACS site. Analysis of those samples showed benzene and lead on site at levels above comparison values (Table 3). Benzene and lead were not detected at levels above the comparison values beyond the boundaries of the site (1).

TABLE 3

RANGE OF CONTAMINANT CONCENTRATIONS IN
ON-SITE SURFACE WATER AND SEDIMENT


CONTAMINANT CONCENTRATION RANGE
(mg/L)
COMPARISON VALUE
(mg/L) Source

SURFACE WATER

     

Benzene
Lead

<0.005-0.46
<0.005-0.0238
0.001
0.005
CREG
PMCL

SEDIMENT

(mg/kg) (mg/kg)  

Benzene
Lead

<0.005-14
<20-702
0.001
*
CREG

NOTE:

mg/L - milligrams per liter (ppm - parts per million)
CREG - Cancer Risk Evaluation Guide
PMCL - Proposed Maximum Contaminant Level
* - No Comparison Value

Source: Warzyn Engineering, Inc. Draft Remedial Investigation Report, ACS NPL Site, Griffith, Indiana. Chicago, Illinois: Warzyn Engineering, Inc., 1990.

Groundwater

Extensive groundwater monitoring (three rounds) has been conducted by Warzyn Engineering at the ACS site (1). Analysis of the groundwater samples indicates that many of the organic chemical and metal soil contaminants have migrated into the upper water table aquifer (Table 4). No contamination at levels above the comparison values was found in the lower aquifer.

TABLE 4

RANGE OF CONTAMINANT CONCENTRATIONS
ON-SITE GROUNDWATER


CONTAMINANT CONCENTRATION RANGE
(mg/L)
COMPARISON VALUE

(mg/L)

Source

Benzene

<0.005-100 0.001 CREG
Toluene <0.005-2.3 2 RfD
Ethylbenzene <0.01-1.1 1 RfD
Xylene (Total) <0.005-3.0 20 RfD
PCB <0.001-0.0026 0.000005 CREG
Chloroethane <0.005-2.0 0.5 Rfd
Vinyl Chloride <0.01-0.72

0.00002

CREG
1,1-Dichloroethane <0.01-2.4 1 RfD
1,2-Dichloroethane (Total) <0.01-0.4 0.0004 CREG
Methyl Ethyl Ketone <0.01-220 2 RfD

Methyl Isobutyl Ketone

<0.01-54 2 RfD
2-Hexanone <0.01-1.8 0.3 RfD
Arsenic <0.005-0.03 0.01 EMEG
Barium <0.005-1.8 0.7 RfD
Manganese <0.005-4.2 1 RfD

NOTE:

mg/L - milligrams per liter (ppm - parts per million)
CREG - Cancer Risk Evaluation Guide
EMEG - Environmental Media Evaluation Guide
RfD - Reference Dose

Source: Warzyn Engineering, Inc. Draft Remedial Investigation Report, ACS NPL Site, Griffith, Indiana. Chicago, Illinois: Warzyn Engineering, Inc., 1990.

Air

No air samples were collected during the RI.

As discussed in the Site Description and History section, the major operations at ACS were solvent recovery and chemical manufacturing. During operations, the same chemicals found at the NPL site could be released to the environment. In order to identify whether ACS discharged additional amounts of site-related chemicals to the environment, ATSDR searched the 1987 and 1988 Toxic Chemical Release Inventory (TRI). TRI is a database developed by EPA from chemical release (air, water, and soil) information provided by certain industries. TRI indicates that ACS discharged to the air six chemicals of concern at the NPL site (1,1,1-trichloroethane, xylene (total), trichloroethene, tetrachloroethene, methyl ethyl ketone, and toluene). The highest air discharges were reported in 1988 (1,1,1-trichloroethane, 452 pounds per year (lbs/yr); xylene (total), 3,671 lbs/yr; trichloroethene, 302 lbs/yr; tetrachloroethene, 72 lbs/yr; methyl ethyl ketone, 5,765 lbs/yr; and toluene 6,190 lbs/yr). All of the reported levels of discharged chemicals are estimated, preventing comparison of the analytical levels for the contaminants found at the NPL site and the ACS discharge to air.

B. OFF-SITE CONTAMINATION

Groundwater

Off-site migration of contaminated upper aquifer groundwater has been confirmed by the Warzyn Engineering investigation. Groundwater samples were collected from off-site monitoring wells and off-site private wells drawing groundwater from the upper and lower aquifers (See Appendix, Figures 3 and 4). Table 5 lists the contaminants of concern found in the off-site groundwater. Warzyn Engineering collected the environmental data presented in this subsection during the RI process from July 1989 through August 1990 (1).

The highest groundwater contamination was found in off-site upper aquifer monitoring wells near the ACS site (1). Groundwater from off-site private wells did not contain any site-related contaminants. One private well contained lead at levels (0.0417 mg/L) above the comparison value of 0.005 mg/L. This private well is an unused industrial supply well north of the site (private well PW-07, see Appendix, Figure 3) (1).

In addition to determining what ACS is discharging to the environment, TRI was searched to determine whether other industries in Griffith are discharging site-related contaminants. TRI did not contain any other information on similar toxic chemical releases in the Griffith area.

Table 5

RANGE OF CONTAMINATION CONCENTRATIONS IN
OFF-SITE MONITORING WELLS AND THE PRIVATE INDUSTRIAL SUPPLY WELL


Contaminant Concentration Range
(mg/L)
Comparison Value
(mg/L) Source

Monitoring Wells

     

Benzene

<0.005-0.012 0.001 CREG
Trichloroethene <0.005-0.045 0.003 CREG
Tetrachloroethene <0.005-0.20 0.0007 CREG
PCB <0.0001-0.027 0.000005 CREG
       

Industrial Supply Well

     

Lead

<0.003-0.0417 0.005 PMCL

NOTE:

mg/L - milligrams per liter (ppm - parts per million)
CREG - Cancer Risk Evaluation Guide
PMCL - Proposed Maximum Contaminant Level

Source: Warzyn Engineering, Inc. Draft Remedial Investigation Report, ACS NPL Site, Griffith, Indiana. Chicago, Illinois: Warzyn Engineering Inc., 1990.

C. QUALITY ASSURANCE AND QUALITY CONTROL

ATSDR was provided with quality assurance and quality control (QA/QC) information about the RI analytic data, indicating that appropriate QA/QC was performed for the samples collected by Warzyn Engineering. The conclusions presented in this public health assessment are based in part on the data presented in the RI report. The validity of the conclusions, therefore, depends on the accuracy and reliability of the data provided.

D. PHYSICAL AND OTHER HAZARDS

No physical or other hazards were noted during the ATSDR site visit, except those normally found at an industrial area.


PATHWAYS ANALYSES

A. ENVIRONMENTAL PATHWAYS (Fate and Transport)

Contaminants of concern could migrate through several environmental pathways. The two primary environmental pathways are groundwater and surface water. To help readers of this assessment better understand pathways, regional hydrogeologic conditions are explained; potential environmental pathways are also discussed.

Regional Hydrogeologic Conditions

The ACS site is on the lake bed of ancient glacial Lake Chicago. The landscape is generally low-lying, and predominantly the result of continental glacial processes and processes associated with the formation of glacial Lake Chicago and the present-day Lake Michigan. Those glacial processes deposited varying layers of sand, gravel, and clay on top of the regional bedrock. Glacial deposits close to the site are approximately 130 feet thick.

Glacial deposits near the ACS site can be divided into three units: an upper sand and gravel unit, an intermediate silty clay unit, and a lower sand and gravel unit. Groundwater is found in both the upper and lower sand and gravel units. The intermediate, silty clay unit acts as a dividing layer between the two groundwater aquifers. This dividing layer, called an aquitard, inhibits the flow of groundwater between the two groundwater aquifers.

Groundwater flow within the upper sand and gravel aquifer follows the contours of the local topography and is influenced by activities at the Griffith Municipal Landfill. Groundwater within the upper aquifer tends to flow in all directions. Groundwater from the upper aquifer discharges north, northeast, west, and southwest to the local marshes and ditches surrounding the NPL site. Groundwater flow south and east has not been completely evaluated, but it appears that Turkey Creek is a discharge point for groundwater flowing in those directions. The upper aquifer is the source of water for a few residences, however, upper aquifer water is not considered potable. (see Appendix, Figure 3).

The lower sand and gravel aquifer is used extensively as a source of potable water. Groundwater in this aquifer flows north and eventually discharges into Lake Michigan.

Surface-water runoff at the site is west and south into local marshes, which drain into Turkey Creek.

Groundwater Pathway

In the past, waste from ACS and Kapica Drum operations was disposed on site. Most of the waste from ACS was buried on site (On-Site Containment area, Still Bottoms area, Treatment Lagoon #1, and Off-Site Containment area). Liquid waste from Kapica Drum was discharged onto the ground. Some waste from the two facilities might have been sent to the Griffith Municipal Landfill. Since the waste was discarded, various toxic substances in it have migrated through the soil into the groundwater (see Tables 4 and 5). Groundwater monitoring data indicate contamination at levels above comparison values is restricted to the upper sand and gravel aquifer. Groundwater contamination in the aquifer is moving in the direction of groundwater flow, but has not migrated very far off site. Analysis of samples taken from local residential wells did not show site-related contaminants; therefore, it is unlikely people have been exposed to the contaminated groundwater. If the migration of contaminated groundwater is not prevented, contaminants from the site could migrate into residential wells.

Results of private well samples showed that one unused industrial supply well (PW-07) was contaminated with lead at levels above comparison values. The lead contamination is probably not related to the ACS site because lead was not detected in groundwater at or near the site, and analyses of a sample from an upgradient private well just south of PW-07 also did not find lead.

Surface Water Pathway

As previously discussed, the upper aquifer discharges into local marshes, ditches, and Turkey Creek. In addition, surface-water runoff from the site and leachate from the Griffith Municipal Landfill drain into the same bodies of water. Analysis of surface-water and sediment samples from the marshes and ditches on site showed site-related contaminants (lead and benzene) at levels above comparison values. Those on-site contaminants probably are the result of migration of contaminated groundwater, surface-water runoff, and leachate. People probably would not contact contaminants on site because access is restricted by a fence. The levels of contamination steadily decrease with distance from the sources of contamination and are at or below background levels before surface water exits the site boundaries. It is therefore unlikely that off-site fish or wildlife have bioaccumulated site-related contaminants.

Waste Material and Soil

Analysis of soil and waste samples taken at the ACS site indicate the soil is contaminated at levels above comparison values at the On-Site Containment, Still Bottoms, Treatment Lagoon #1, Off-Site Containment, and Kapica/Pazmey areas. Contamination at the On-Site Containment, Still Bottoms, Treatment Lagoon #1, and Off-Site Containment areas is located several feet below the surface. People probably will not contact the soil contamination except during excavation of the soil. Groundwater will continue to be contaminated, however, unless the site is remediated.

The Kapica/Pazmey area subsurface soil has elevated concentrations of PCBs and metals. Some contaminants may be in the surface soils (0-3 inches) because drum rinse water and liquid waste were reportedly discharged directly onto the ground. Wind erosion, traffic patterns (truck movement), and surface-water runoff could transport those contaminants off site. Surface soil sampling is needed to confirm whether contamination is of public health concern.

Air

Although no air monitoring was conducted on site, it is unlikely that significant amounts of site-related contaminants are being released into the air because most of the volatile contaminants (e.g., benzene) are several feet below the soil surface. Routine air monitoring with hand-held instruments (e.g., organic vapor analyzer) did not detect air contamination except when subsurface soils were excavated.

One possible environmental pathway that has not been investigated is whether methane gas is being generated at and migrating from the Griffith Municipal Landfill. As solid waste material decomposes, methane is produced. Because waste material from ACS and Kapica Drum were reported to be disposed in the landfill, it is likely that hazardous substances are in the landfill. Therefore, methane and volatile hazardous substances (e.g., benzene) could travel through the unsaturated soil, above the groundwater, into nearby buildings. Analysis of landfill gas should be conducted to evaluate that possible pathway, and gas monitoring should be a part of an overall environmental monitoring and control program for the landfill (e.g., groundwater monitoring and control of contaminant migration).

B. HUMAN EXPOSURE PATHWAYS

Using information from the environmental pathways evaluation, there do not appear to be current or past human exposures to site-related contaminants at levels of public health concern.

Groundwater monitoring data clearly indicate that no site-related contaminants have migrated to potable water wells (e.g., residential wells). In the future, however, contaminated groundwater could enter local residential wells and people could be chronically exposed to site-related contaminants at levels of public health concern. The contaminants most likely to migrate into local residential wells are benzene, trichloroethene, and tetrachloroethene, the primary constituents of the groundwater contaminant plume that has migrated off site.

Most of the soil contamination (On-Site Containment, Still Bottoms, Treatment Lagoon #1, and Off-Site Containment areas) is under several feet of clean soil, which would prevent human exposure except when the soil is excavated. If the subsurface soil contamination is excavated, people could ingest, inhale, or have skin contact with it. Standard dust control and personal protective procedures should prevent that type of exposure.

There may be some surface soil contamination with PCBs and heavy metals (lead, barium, and cadmium) in the Kapica/Pazmey area. If surface soil in that area is contaminated, people could ingest, inhale, or have skin contact with contaminants. The Kapica/Pazmey area is visited only to move stored boats and cars, therefore, any human exposure is not likely to be significant. Surface soil must be sampled before this pathway can be evaluated further.

Analysis of off-site surface water and sediments did not show contamination at levels above background or of public health concern. People probably would not ingest on-site fish or wildlife that have bioaccumulated lead or other site-related contaminants because there is no on-site fishing or hunting.


PUBLIC HEALTH IMPLICATIONS

A. TOXICOLOGIC EVALUATION

Although many contaminants were detected at the ACS site at levels of public health concern, available information indicates there are no completed human exposure pathways. If the contaminants continue to migrate, however, people could be exposed to groundwater contamination by way of ingestion, skin contact, or even inhalation. The groundwater contaminants most likely to migrate into local residential wells are benzene, trichloroethene, and tetrachloroethene; their toxicologic implications are discussed in the following paragraphs. Because the three compounds have similar toxicologies, they are discussed together.

In addition, surface soil in the Kapica/Pazmey area (on-site) may be contaminated. If so, people could ingest, inhale, or have skin contact with the PCBs and heavy metals (lead, barium, and cadmium). The toxicologic implications of the compounds also are discussed.

Benzene, Trichloroethene, and Tetrachloroethene

Studies of workers indicate that benzene, trichloroethene, and tetrachloroethene effects depend on the amount and length of exposure. Inhalation and skin contact were the routes of exposure examined during most of those studies. Exposure to 10 ppm benzene, 50 ppm trichloroethene or 50 ppm tetrachloroethene in the air can cause eye, nose, and throat irritation. As an individual's exposure increases, central nervous system effects appear, including headaches, dizziness, poor coordination, and loss of memory. Skin irritation, nausea, vomiting, and diarrhea can occur, as well as loss of feeling and/or pain in the hands or feet (2,3,4).

Exposure to high levels of those chemicals in the air can damage the lungs, liver, and kidneys. Chronic exposure to lower amounts can also affect those organs. Animals with long-term exposure to trichloroethene appear to have immune system effects. Short-term benzene exposure also affects the immune systems of animals. It has not been determined whether tetrachloroethene affects the immune systems of people or animals (2,3,4).

All three chemicals have been evaluated for their ability to cause cancer. Benzene is considered a human carcinogen; studies of human exposures to trichloroethene and tetrachloroethene are not considered adequate to prove or disprove an association. Results of some animal studies indicate tetrachloroethene could cause cancer in humans. Trichloroethene studies in animals are not adequate to make conclusions about its ability to cause cancer (2,3,4).

The ability of those chemicals to affect the reproductive process or the fetus (i.e., cause birth defects) has been evaluated. Animals tests indicate that high doses of benzene, trichloroethene, and tetrachloroethene can cause both reproductive effects and birth defects. Those studies are inconclusive, however, on whether the chemicals could cause such effects in people (2,3,4).

How benzene, trichloroethene, and tetrachloroethene enter people's bodies can influence the health effects experienced. When inhaled or ingested, a high percentage of the chemicals move into the bloodstream. The health effects of ingestion, therefore, could be similar to inhalation of equivalent concentrations. The health effects of skin contact are probably not similar to those of inhalation or ingestion because less of the chemicals move from the skin into the bloodstream (2,3,4).

Whether or not health effects occur is affected by how long it takes the body to process (metabolize) and eliminate a chemical and how much of the chemical is stored. As exposure continues slow metabolism and/or long-term storage results in a steady decrease in the amount needed to cause health effects. Benzene, trichloroethene, and tetrachloroethene are eliminated from the body in a few days to a week. Little or nothing is stored in the body (2,3,4).

PCBs

PCBs are chemicals that were manufactured until 1977 for use as coolants and lubricants in transformers and other electrical equipment. PCBs can still be found in older electrical equipment, and there is extensive, low-level PCB contamination of the environment (5).

Studies of human exposure indicate that PCBs can irritate the skin and cause liver effects. Those studies did not identify the relationship between dose and effect. Limited evidence from human studies suggests that PCBs can cause cancer, reproductive effects, and birth defects (5).

PCBs can enter the body by way of inhalation, ingestion, or skin contact. The rate at which PCBs enter the body through those routes has not yet been clearly identified (5).

PCBs are metabolized and eliminated from the body with in days, or they can be stored in the body for years. The rate of elimination and amount stored depends on the type of PCB exposure (5).

Lead

Exposure to lead causes a wide range of effects. Short-term exposures above 0.05 ppm in air affect the central nervous system (headaches, dizziness, etc.) and gastrointestinal tract (nausea, diarrhea, and vomiting). Higher amounts can affect the production of blood, kidney and heart functions, and behavior. Long-term exposure of adults to lead above 0.05 ppm in water has similar effects, it also causes blood pressure to rise. Lead is strongly linked with decreases in IQ, mood disorders, memory loss, poor coordination, and decreased function of the thyroid and adrenal glands. Children are especially sensitive to lead; the same effects are observed in them at half the concentration (6).

Lead is considered a possible human carcinogen based on studies in experimental animals. Investigations of an association between lead exposure and cancer in workers have produced contradictory results (6).

Lead can affect both the reproductive process and development of the fetus. Effects include reduced production of sperm, premature birth, low birth weight, and after birth-learning disabilities (6).

Lead enters the blood much easier by way of inhalation and ingestion than by skin contact. It is eliminated slowly from the body; much of it is stored in the bones. Because lead remains in the body, the amount needed to cause an effect decreases as length of exposure increases (6).

Barium

There is not much information on barium's effects on people's health. Studies of a small number of people who ingested large doses of barium showed effects on the respiratory, cardiovascular, and central nervous systems and on the liver, kidney, and spleen. Lower concentrations of barium, however, are often used in making x-rays of the stomach or intestine and have never been found to be harmful. There are no valid data on whether barium causes cancer, birth defects, or reproductive effects in humans or animals (7).

Barium enters the blood much easier by way of inhalation than ingestion. It is very difficult for barium to enter the body following skin contact. Barium is eliminated from the body in one to two weeks; whatever remains is stored in the bones. It is not known whether the stored barium causes health effects (7).

Cadmium

Exposure to cadmium causes a variety of health effects in humans. Ingestion of 0.1 milligram cadmium per kilogram body weight per day (mg/kg/day) can cause nausea, vomiting, and diarrhea. Inhalation of more than 0.1 ppm cadmium in air causes irritation of the respiratory tract. Long-term exposure can damage the kidneys and lungs. Limited evidence from human studies suggests that cadmium can cause lung cancer, but there is no evidence that cadmium causes birth defects or reproductive problems in people (8).

Data from animal studies indicates that cadmium can cause cancer, reproductive and birth defects, and liver damage, and that the metal affects the immune and central nervous systems (8).

Cadmium enters the blood much easier by way of inhalation than by ingestion. Cadmium does not easily enter the body by way of skin contact. Cadmium is eliminated slowly from the body; much of it is stored in the bones. Because it remains in the body, the amount needed to cause an effect decreases as length of exposure increases (8).

B. Health Outcome Data Evaluation

The primary health concern of the individuals who petitioned ATSDR (see Community Health Concerns section) is a high frequency of cancer occurring within an 8-block area north of the ACS site. The types of cancers reported are breast, brain, uterus, and leukemia.

As indicated in the Human Exposure Pathways section, there is no documentation indicating that human exposures to site-specific contaminants are occurring or have occurred. Therefore, it is unlikely that the health outcomes reported by the petitioners are associated with the ACS site.

Cancer of the breast or uterus has not been shown to be associated with environmental agents (9). Cancers of the lung, brain, and colon-rectum, and leukemia, have been associated with environmental agents. Two of the most important environmental factors associated with cancer are tobacco use (up to 35% of cancer deaths) and diet (up to 35% of all cancer deaths). Some hazardous substances have been associated with specific types of cancer (e,g. occupational asbestos exposure and lung cancer, occupational benzene exposure and leukemia, and residential radon exposure and lung cancer) (10).

In an attempt to address this community health concern, the Indiana State Board of Health provided ATSDR with 1987-1989 cancer incidence data for the City of Griffith from the Indiana Cancer Registry and with 1970-1979 site-specific cancer mortality rates by race and gender for the United States, Indiana, and Lake County. In addition, ATSDR reviewed 1950-1979 cancer mortality data for Lake County from the Riggans Cancer Mortality database.

Review of the incidence data showed percentages of site-specific cancers for Griffith (population 17,916 - 1990 U.S. Census) to be comparable to percentages for U.S. as a whole. The four types of cancer that occurred most often in Griffith were lung, colon-rectum, cervix, and breast. Review of mortality rates showed more deaths than expected in Lake County for all cancer sites combined compared to the State of Indiana. The data were limited; it was not possible to identify cases occurring in the 8-block area of concern to the petitioners. Information is not available on numbers of specific cancers and characteristics of the affected persons.

A health statistics review could be conducted in the future, when the Indiana Cancer Registry will have additional years of data and the ability to identify cases occurring in the 8-block area of concern. A health statistics review could better quantify and characterize the specific cancer cases of concern to the petitioners and help identify public health education needs.

C. Community Health Concerns Evaluation

During the April 1990 site visit, ATSDR listened to community health concerns of the individuals who petitioned the Agency.

1. The petitioners believe there ares high frequencies of breast, brain, uterus, lung, and leukemia cancer occurring in an 8-block area north of the ACS site.

As indicated in the Human Exposure Pathways and Health Outcome Data sections, there is no documentation human exposure to site-related contaminants. Therefore, it is unlikely that the human health outcomes reported by the petitioners are associated with the ACS site.

2. The petitioners are concerned that the oil and solvent discharge from the Griffith Airport might have contaminated their residential wells.

As a result of information provided by the Indiana State Board of Health, EPA, and ATSDR, the Indiana Department of Environmental Management (IDEM) conducted a preliminary assessment in February 1991, and a site investigation in October 1991, on the Griffith Airport oil and solvent discharge. IDEM concluded that no further remedial action for the Griffith Airport is warranted.

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