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PUBLIC HEALTH ASSESSMENT

PANTEX PLANT
AMARILLO, CARSON COUNTY, TEXAS

APPENDIX E.

Health Outcome Data Tables
Table 1 Summary of Birth Defect Check Box Categories in theTexas Birth Certificate and Fetal Death Certificate (11)
Category of BirthDefectDescription of Birth Defect Category
AnencephalusCongenital absence of the cranial vault, with cerebralhemispheres completely missing or reduced to small massesattached to the base of the skull.
Spina Bifida /meningoceleA developmental anomaly characterized by defective closure ofthe bony encasement of the spinal cord, through which the cordand meninges may or may not protrude.
HydrocephalusA condition characterized by abnormal accumulation of fluid inthe cranial vault, accompanied by enlargement of the head.
MicrocephalusAbnormal smallness of the head.
Other central nervoussystem anomalies  
Heart malformationsMalformations of the heart.
Other circulatory /respiratory anomalies  
Rectal atresia / stenosisAtresia (imperforation; absence or closure of normal opening) orstenosis (narrowing) of the rectum or anus.
Tracheo-esophagealfistula / esophagealatresiaTracheo-esophageal fistula: opening between the trachea andesophagus. Atresia: absence of open canal of the esophagus.
Omphalocele /gastroschisisProtrusion at birth of part of the intestine through a large defectin the abdominal wall. In omphalocele, usually covered by athin membrane. Different etiologies.
Other gastrointestinalanomalies  
Malformed genitalia  
Renal agenesisCongenital absence of one or both kidneys.
Other urogenitalanomalies  
Cleft lip/palateFissure or gap in the upper lip and/or palate.
Polydactyly / syndactyly Polydactyly: too many fingers or toes.
Syndactyly: fingers or toes fused together.
Limb reductionsParts of hand, arm, foot, or legs missing.
Club footA deformity of the foot in which it is twisted out of shape orposition, referred to medically as talipes.
Diaphragmatic herniaThe protrusion of an organ through a defect in the diaphragm.
Other musculoskeletal /integumental anomalies  
Down syndromeA chromosomal abnormality characterized by moderate tosevere mental retardation, epicanthal folds in eyes, slopingforehead, flat-bridged nose, short phalanges. Caused by an extrachromosome 21 (trisomy 21). Old name: mongolism (due tocharacteristic eye features).
Other chromosomalanomaliesSeveral, including trisomy 13 (Patau syndrome), trisomy 18(Edward syndrome).
Other congenitalanomaliesCatchall category, if something present that doesn't fit into oneof the categories above.

References: California Birth Defects Monitoring Program. A glossary of birth defects terminology. 1983.

Goodman RM, Gorlin RJ. The Malformed Infant and Child: An Illustrated Guide (Glossary). New York; Oxford University Press, 1983.

Appendix E Table 2

The following table was not available in electronic format for conversion to HTML at the time of preparation of this document. To obtain a hard copy of the document, please contact:

Agency for Toxic Substances and Disease Registry
Division of Health Assessment and Consultation
Attn: Chief, Program Evaluation, Records, and Information Services Branch E-56
1600 Clifton Road NE, Atlanta, Georgia 30333

Appendix E Table 3

The following table was not available in electronic format for conversion to HTML at the time of preparation of this document. To obtain a hard copy of the document, please contact:

Agency for Toxic Substances and Disease Registry
Division of Health Assessment and Consultation
Attn: Chief, Program Evaluation, Records, and Information Services Branch E-56
1600 Clifton Road NE, Atlanta, Georgia 30333

Appendix E

Table 4.

Birth Defects Zip Code Analysis 1990-1994
CONDITIONOBSEXPOER95% CI
Microcephalus60.3218.756.88 - 40.88
Heart Malformations183.495.163.06 - 8.15
Other Circulatory/Respiratory Anomalies212.408.755.24 - 13.39
Tracheo-Esophageal Fistula/Esophageal Atresia20.287.140.86 - 25.79
Other Gastrointestinal Anomalies30.744.050.84 - 11.84
Malformed Genitalia72.752.551.02 - 5.24
Other Urogenital Anomalies142.545.513.01 - 9.26
Club Foot91.914.712.16 - 8.95
Other Muscular skeletal/Integumental Anomalies174.453.822.23 - 6.11

Appendix E Table 5

The following table was not available in electronic format for conversion to HTML at the time of preparation of this document. To obtain a hard copy of the document, please contact:

Agency for Toxic Substances and Disease Registry
Division of Health Assessment and Consultation
Attn: Chief, Program Evaluation, Records, and Information Services Branch E-56
1600 Clifton Road NE, Atlanta, Georgia 30333

Appendix E Table 6

The following table was not available in electronic format for conversion to HTML at the time of preparation of this document. To obtain a hard copy of the document, please contact:

Agency for Toxic Substances and Disease Registry
Division of Health Assessment and Consultation
Attn: Chief, Program Evaluation, Records, and Information Services Branch E-56
1600 Clifton Road NE, Atlanta, Georgia 30333

Appendix E Table 7

The following table was not available in electronic format for conversion to HTML at the time of preparation of this document. To obtain a hard copy of the document, please contact:

Agency for Toxic Substances and Disease Registry
Division of Health Assessment and Consultation
Attn: Chief, Program Evaluation, Records, and Information Services Branch E-56
1600 Clifton Road NE, Atlanta, Georgia 30333

Appendix E

Table 8.

Observed to Expected Ratios for Low Birth Weight by County, 1990-1994
COUNTYOBSEXPOER95% CI
Armstrong127.671.570.81 - 2.74
Carson4026.901.4911.06 - 2.022
Potter919711.211.2911.21 - 1.38
Randall430444.290.970.88 - 1.06

1 Significantly higher (at the 5% level) than expected.

Table 9.

Armstrong County 1985-1993 Cancer Incidence and Race-Adjusted Standardized Incidence Ratios (13)
    MALES  
  Site Observed Expected SIR 95% CI
Lung 7

12.47

0.56

0.23-1.16

Bone 0

0.09

-

-

Prostate 8

22.30

0.36*

0.15- 0.71

Brain 1

0.96

1.04

0.03-5.80

Thyroid 0

0.31

-

-

Leukemia 2

1.90

1.05

0.13-3.80

All Sites 52

72.17

0.72*

0.54- 0.94

FEMALES
Site Observed Expected SIR 95% CI
Lung 2

8.66

0.23*

0.03- 0.83

Bone 0

0.11

-

-

Breast 6

18.47

0.32*

0.12- 0.71

Brain 0

0.79

-

-

Thyroid 0

0.72

-

-

Leukemia 1

1.37

0.73

0.02-4.07

All Sites 26

61.44

0.42*

0.28- 0.62

Note: The SIR (standardized incidence ratio) is defined as the number of observed cases divided by the number of expected cases. The latter is based on race-, sex-, and age-specific cancer incidence rates for California, 1988-1992 (cancer incidence rates for five regions of Texas, 1985-1991 were used to calculate bone cancer expected cases because California rates were not available).
* Significantly lower (at the 5% level) than expected.

 

Appendix E

Table 10.

Carson County 1985-1993 Cancer Incidence and Race-Adjusted Standardized Incidence Ratios (13)
  MALES 
Site Observed Expected SIR 95% CI
Lung 28

30.86

0.91

0.60-1.31

Bone 0

0.28

-

-

Prostate 46

52.40

0.88

0.64-1.17

Brain 0

2.71

-

-

Thyroid 0

0.93

-

-

Leukemia 5

4.83

1.04

0.34-2.42

All Sites 150

178.88

0.84*

0.71- 0.98

FEMALES
Site Observed Expected SIR 95% CI
Lung 10

21.65

0.46*

0.22- 0.85

Bone 1

0.32

3.13

0.08-17.41

Breast 35

48.58

0.72

0.50-1.00

Brain 3

2.18

1.38

0.28-4.02

Thyroid 1

0.08

12.50

0.32-69.64

Leukemia 6

3.40

1.76

0.65-3.84

All Sites 136

156.14

0.87

0.73-1.03

Note: The SIR (standardized incidence ratio) is defined as the number of observed cases divided by the number of expected cases. The latter is based on race-, sex-, and age-specific cancer incidence rates for California, 1988-1992 (cancer incidence rates for five regions of Texas, 1985-1991 were used to calculate bone cancer expected cases because California rates were not available).
* Significantly lower (at the 5% level) than expected.

 

Appendix E

Table 11.

Potter and Randall Counties Combined 1985-1993
Cancer Incidence and Race-Adjusted Standardized Incidence Ratios (13)
MALES
Site Observed Expected SIR 95% CI
Lung 624

626.49

0.99

0.92-1.08

Bone 7

7.18

0.97

0.39-2.01

Prostate 879

1011.32

0.87*

0.81- 0.93

Brain 53

62.04

0.85

0.64-1.12

Thyroid 20

22.04

0.91

0.55-1.40

Leukemia 103

103.00

1.00

0.82-1.21

All Sites 3460

3662.52

0.94*

0.91- 0.97

FEMALES
Site Observed Expected SIR 95% CI
Lung 372

493.84

0.75*

0.68- 0.83

Bone 4

8.48

0.47

0.13-1.21

Breast 906

1148.00

0.79*

0.74- 0.84

Brain 42

53.77

0.78

0.56-1.06

Thyroid 67

62.33

1.07

0.83-1.37

Leukemia 88

82.37

1.07

0.86-1.32

All Sites 4015

3693.56

1.09**

1.06-1.12

Note: The SIR (standardized incidence ratio) is defined as the number of observed cases divided by the number of expected cases. The latter is based on race-, sex-, and age-specific cancer incidence rates for California, 1988-1992 (cancer incidence rates for five regions of Texas, 1985-1991 were used to calculate bone cancer expected cases because California rates were not available).
* Significantly lower (at the 5% level) than expected.
** Significantly higher (at the 5% level) than expected.

 

Appendix E

Table 12.

Armstrong, Carson, and Potter/Randall Counties 1985-1993 Leukemia by Cell Type and Race-Adjusted Standardized Incidence Ratios (13)
MALES
County/Site# Observed Expected SIR* 95% CI
ARMSTRONG
ALL
AML
CLL
CML		 0
0
2
0		 0.2
0.5
0.6
0.3		 -
-
3.1
-		 -
-
0.4 -11.3
-
CARSON
 ALL
AML
CLL
CML		 1
0
2
0		 0.5
1.2
1.5
0.7		 1.9
-
1.3
-		 0.0 -10.5
-
0.2 - 4.7
-
POTTER/RANDALL
 ALL
AML
CLL
CML		 12
19
46
13		 15.0
25.9
30.1
13.9		 0.8
0.7
1.5**
0.9		 0.4 - 1.4
0.4 - 1.2
1.1 - 2.0
0.5 - 1.6

Note: The SIR (standardized incidence ratio) is defined as the number of observed cases divided by the number of expected cases. The latter is based on race-, sex-, and age-specific cancer incidence rates for California during the period 1988-1993.
* The SIR has been rounded to the first decimal place.
** Significantly higher (at the 5% level) than expected.
# Acute lymphocytic leukemia (ALL), acute myelocytic leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myelocytic leukemia (CML)

Table 13.

Armstrong, Carson, and Potter/Randall Counties 1985-1993 Leukemia by Cell Type and Race-Adjusted Standardized Incidence Ratios (13)
FEMALES
County/Site# Observed Expected SIR* 95% CI
ARMSTRONG
ALL
AML
CLL
CML

0
0
1
0

 0.1
0.4
0.5
0.2		 -
-
2.2
-		 -
-
0.1 -12.1
-
CARSON
ALL
AML
CLL
CML		 0
2
2
0		 0.4
1.0
1.1
0.4		 -
2.1
1.9
-		 -
0.3 - 7.5
0.2 - 6.8
-
POTTER/RANDALL
ALL
AML
CLL
CML		 10
24
33
11		 11.8
23.8
23.9
9.6		 0.8
1.0
1.4
1.1		 0.4 - 1.6
0.7 - 1.5
1.0 -1.9
0.6 - 2.1

Note: The SIR (standardized incidence ratio) is defined as the number of observed cases divided by the number of expected cases. The latter is based on race-, sex-, and age-specific cancer incidence rates for California during the period 1988-1993.
* The SIR has been rounded to the first decimal place.
# Acute lymphocytic leukemia (ALL), acute myelocytic leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myelocytic leukemia (CML)

Appendix E

Table 14.

Armstrong County 1985-1994 Cancer Deaths and Race-Adjusted Standardized Mortality Ratios (13)
MALES
Site Observed Expected SMR 95% CI
Lung 10

13.29

0.75

0.36-1.38

Bone 1

0.10

10.00

0.25-55.71

Prostate 3

4.55

0.66

0.14-1.93

Brain 1

0.83

1.20

0.03-6.71

Thyroid 0

0.04

-

-

Leukemia 2

1.51

1.32

0.16-4.78

All Sites 32

37.47

0.85

0.58-1.21

FEMALES
Site Observed Expected SMR 95% CI
Lung 3

6.63

0.45

0.09-1.32

Bone 0

0.08

-

-

Breast 5

4.51

1.11

0.36-2.59

Brain 0

0.68

-

-

Thyroid 0

0.07

-

-

Leukemia 1

1.11

0.90

0.02-5.02

All Sites 19

28.43

0.67

0.40-1.04

Note: The SMR (standardized mortality ratio) is defined as the number of observed deaths divided by the number ofexpected deaths. The latter is based on race-, sex-, and age-specific cancer mortality rates for Texas during theperiod 1985-1994.

Appendix E

Table 15.

Carson County 1985-1994 Cancer Deaths and Race-Adjusted Standardized Mortality Ratios (13)
MALES
Site Observed Expected SMR 95% CI
Lung 24

32.60

0.74

0.47-1.10

Bone 0

0.28

-

-

Prostate 6

10.08

0.60

0.22-1.30

Brain 2

2.21

0.91

0.11-3.27

Thyroid 0

0.10

-

-

Leukemia 6

3.70

1.62

0.60-3.53

All Sites 68

90.73

0.75*

0.58- 0.95

FEMALES
Site Observed Expected SMR 95% CI
Lung 8

16.34

0.49*

0.21- 0.96

Bone 0

0.20

-

-

Breast 6

11.48

0.52

0.19-1.14

Brain 4

1.78

2.25

0.61-5.75

Thyroid 0

0.16

-

-

Leukemia 6

2.63

2.28

0.84-4.97

All Sites 55

68.82

0.80

0.60-1.04

Note: The SMR (standardized mortality ratio) is defined as the number of observed deaths divided by the number of expected deaths. The latter is based on race-, sex-, and age-specific cancer mortality rates for Texas during the period 1985-1994.
* Significantly lower (at the 5% level) than expected.

Appendix E

Table 16.

Potter County 1985-1994 Cancer Deaths and Race-Adjusted Standardized Mortality Ratios (13)
MALES
Site Observed Expected SMR 95% CI
Lung 384

368.52

1.04

0.94-1.15

Bone 1

3.34

0.30

0.01-1.67

Prostate 158

117.52

1.34*

1.14-1.57

Brain 29

25.05

1.15

0.78-1.66

Thyroid 1

1.24

0.81

0.02-4.49

Leukemia 43

42.49

1.01

0.73-1.36

All Sites 1140

1044.87

1.09*

1.03-1.16

FEMALES
Site Observed Expected SMR 95% CI
Lung 211

211.36

1.00

0.87-1.14

Bone 4

2.89

1.38

0.38-3.54

Breast 175

156.19

1.12

0.96-1.30

Brain 31

23.27

1.33

0.91-1.89

Thyroid 2

2.39

0.84

0.10-3.02

Leukemia 39

37.23

1.05

0.74-1.43

All Sites 986

946.07

1.04

0.98-1.11

Note: The SMR (standardized mortality ratio) is defined as the number of observed deaths divided by the number of expected deaths. The latter is based on race-, sex-, and age-specific cancer mortality rates for Texas during the period 1985-1994.
* Significantly higher (at the 5% level) than expected.

Appendix E

Table 17.

Randall County 1985-1994 Cancer Deaths and Race-Adjusted Standardized Mortality Ratios (13)
MALES
Site Observed Expected SMR 95% CI
Lung 202

292.98

0.69*

0.60- 0.79

Bone 1

2.76

0.36

0.01-2.02

Prostate 101

75.85

1.33**

1.08-1.62

Brain 25

23.00

1.09

0.70-1.60

Thyroid 0

0.97

-

-

Leukemia 17

33.34

0.51*

0.30-0.82

All Sites 693

802.85

0.86*

0.80- 0.93

FEMALES
Site Observed Expected SMR 95% CI
Lung 129

161.01

0.80*

0.67- 0.95

Bone 1

2.18

0.46

0.01-2.56

Breast 108

119.44

0.90

0.74-1.09

Brain 22

19.10

1.15

0.72-1.74

Thyroid 1

1.51

0.66

0.02-3.69

Leukemia 20

25.92

0.77

0.47-1.19

All Sites 601

676.20

0.89*

0.82- 0.96

Note: The SMR (standardized mortality ratio) is defined as the number of observed deaths divided by the number of expected deaths. The latter is based on race-, sex-, and age-specific cancer mortality rates for Texas during the period 1985-1994.
* Significantly lower (at the 5% level) than expected.
** Significantly higher (at the 5% level) than expected.

Appendix E

Table 18.

Armstrong County 1980-1994 Selected Diseases and Age, Race-Adjusted Standardized Mortality Ratios
Males
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

0

0.095

--

--

Multiple Sclerosis

0

0.069

--

--

Amyotrophic LateralSclerosis

0

0.343

--

--

Lupus

0

0.097

--

--

Females
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

0

0.050

--

--

Multiple Sclerosis

0

0.105

--

--

Amyotrophic LateralSclerosis

0

0.293

--

--

Lupus

0

0.302

--

--


Table 19.

Carson County 1980-1994 Selected Diseases and Age, Race-Adjusted Standardized Mortality Ratios
Males
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

3

0.310

9.68*

1.99 - 28.25

Multiple Sclerosis

0

0.196

--

--

Amyotrophic LateralSclerosis

0

0.908

--

--

Lupus

0

0.266

--

--

Females
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

0

0.142

--

--

Multiple Sclerosis

0

0.309

--

--

Amyotrophic LateralSclerosis

0

0.758

--

--

Lupus

2

0.830

2.41

0.29 - 8.70

* Significantly higher (at the 5% level) than expected.

Appendix E

Table 20.

Potter County 1980-1994 Selected Diseases and Age, Race-Adjusted Standardized Mortality Ratios
Males
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

9

3.95

2.28*

1.04 - 4.33

Multiple Sclerosis

5

2.12

2.36

0.76 - 5.50

Amyotrophic LateralSclerosis

17

9.88

1.72

1.00 - 2.76

Lupus

5

3.68

1.36

0.44 - 3.17

Females
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

0

1.83

--

--

Multiple Sclerosis

5

3.97

1.26

0.41 - 2.93

Amyotrophic LateralSclerosis

12

9.55

1.26

0.65 - 2.20

Lupus

16

13.91

1.15

0.66 - 1.86

* Significantly higher (at the 5% level) than expected.

Table 21.

Randall County 1980-1994 Selected Diseases and Age, Race-Adjusted Standardized Mortality Ratios
Males
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

2

3.62

0.55

0.07 - 1.99

Multiple Sclerosis

2

1.97

1.02

0.12 - 3.66

Amyotrophic LateralSclerosis

12

8.10

1.48

0.77 - 2.59

Lupus

0

2.57

--

--

Females
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

0

1.50

--

--

Multiple Sclerosis

10

3.45

2.90*

1.39 - 5.33

Amyotrophic LateralSclerosis

8

6.85

1.17

0.50 - 2.30

Lupus

5

8.63

0.58

0.19 - 1.35

* Significantly higher (at the 5% level) than expected.

Appendix E

Table 22.

Potter/Randall Counties Combined 1980-1994 Selected Diseases and Age, Race-Adjusted Standardized Mortality Ratios
Males
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

11

7.58

1.45

0.72 - 2.60

Multiple Sclerosis

7

4.09

1.71

0.69 - 3.53

Amyotrophic LateralSclerosis

29

17.99

1.62*

1.08 - 2.32

Lupus

5

6.25

0.80

0.26 - 1.86

Females
Disease Observed Expected SMR 95% CI
Muscular Dystrophy

0

3.33

--

--

Multiple Sclerosis

15

7.42

2.02*

1.13 - 3.34

Amyotrophic LateralSclerosis

20

16.41

1.22

0.74 - 1.88

Lupus

21

22.54

0.93

0.58 - 1.43

* Significantly higher (at the 5% level) than expected.



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