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EXPOSURE INVESTIGATION REPORT

SOLUTIA INCORPORATED/MONSANTO COMPANY
ANNISTON, CALHOUN COUNTY, ALABAMA


REFERENCES

  1. R. Canady, Agency for Toxic Substances and Disease Registry, Draft Health Consultation; Evaluation of Soil, Blood, and Air Data from Anniston, Alabama; February 14, 2000.

  2. A. C. Rencher; Methods of Multivariate Analysis; John Wiley and Sons, Inc.; New York 1995.

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  4. DL Phillips et al; Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding; Arch. Environ. Contam. Toxicol. 18 495-500 (1989).

  5. Agency for Toxic Substances and Disease Registry; Toxicological Profile for Polychlorinated Bihenyls (update); Draft for Public Comment; December 1998.

  6. DT Miller et al; Human exposure to polychlorinated biphenyls in greater New Bedford, Massachusetts: A prevalence study; Arch. Environ. Contam. Toxicol. 20 410-416 (1991).

  7. SL Gerstenberger et al; concentrations of blood and hair mercury and serum PCBs in an Ojibwa population that consumes Great Lakes region fish; Clinical Toxicol. 35 377-386 (1997).

  8. Kathleen Kreiss; Studies on populations exposed to polychlorinated biphenyls; Env. Health Perspec. 60 193-199 (1985).

  9. MP Longnecker et al; Correlations among human plasma levels of dioxin-like compounds and polychlorinated biphenyls (PCBs) and implications for epidemiologic studies; Arch. Env. Health 55 195-200 (2000).

  10. Larry G. Hansen; Stepping backward to improve assessment of PCB congener toxicities; Env. Health Perspec. 106 171-189 (1998).

  11. H Humphrey et al; PCB congener profile in the serum of humans consuming Great Lakes fish; Env. Health Perspec. 108 167-172 (2000).

  12. JF Brown; Determination of PCB metabolic, excretion, and accumulation rates for use as indicators of biological response and relative risk; Environ. Sci. Technol. 28 2295-2305 (1994).

  13. H Ouw et al; Use and health effects of Aroclor 1242, a polychlorinated biphenyl, in an electrical industry; Archives Environ. Health 31 189-194 (1976).

  14. A. Fischbein et al; Dermatological findings in capacitor manufacturing workers exposed to dielectric fluids containing polychlorinated biphenyls (PCBs); 37 69-74 (1982).

  15. JL Jacobson et al; Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive function in young children; J. Pediatrics 116 38-45 (1990).

  16. WJ Rogan and BC Gladen; Study of human lactation for effects of environmental contaminants: the North Carolina breast milk and formula project and some other ideas; Environ Health Perspect. 60 215-221 (1985).

  17. SL Schantz; Developmental neurotoxicity of PCBs in humans: What do we know and where do we go from here? Neurotox. Teratology 18 217-227 (1996).

  18. RF Segal; Epidemiological and laboratory evidence of PCB-induced neurotoxicity; 26 709-737 (1996).

  19. U.S. Environmental Protection Agency, Solid Waste and Emergency Response; A Guide on Remedial Actions at Superfund Sites With PCB Contamination; Directive 9355.4-01 FS; August 1990.

  20. DJ Paustenbach, BL Finley, and TF Long; The critical role of house dust in understanding the hazards posed by contaminated soils; Int J Toxicol; 16 339-362 (1997).

  21. JH Shirai and JC Kissel; Uncertainty in estimated half-lives of PCBs in humans: impact on exposure assessment; Science of the Total Environment 187 199-210 (1996).

  22. JD Sahl et al; Polychlorinated biphenyls in the blood of personnel from an electric utility; J Occup Med 27 639-643 (1985).

  23. MS Wolf et al; Blood levels of organochlorine residues and risk of breast cancer; J Nat Cancer Inst 85 648-652 (1993).

  24. ME Hovinga et al; Historical changes in serum PCB and DDT levels in an environmentally -exposed cohort; Arch Environ Contam Toxicol 22 362-366 (1992).

  25. DJ Hunter et al; Plasma organochlorine levels and the risk of breast cancer; New Eng J Med; 337 1253-1258 (1997).

  26. HEB Humphrey et al; PCB congener profile in the serum of humans consuming great lakes fish; Environ Health Perspec 108 167-172 (2000).

  27. LP Hanrahan et al; Serum PCB and DDE levels of frequent Great Lakes sport fish consumers - A first look; Environ Research Section A 80 S26-S37 (1999).

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  29. A Schecter et al; Polychlorinated biphenyl levels in the tissues of exposed and nonexposed humans; Environ Health Perspect 102 Suppl 1: 149-158 (1994).


TABLES

Table 1.

Blood Serum PCB concentrations (ppb) in adults
Mean Median Number tested Date of testing Location Notes Reference
5 4 738 1982-1984 California pre-employment screening Sahl et al [22]
5.8 3.9 840 1985-1986 Massachusetts random sample - New Bedford, MA Miller et al [6]
6.7 - 171 1985-1991 New York City breast cancer controls Wolff et al [23]
6.8 - 90 1989 Michigan controls for fish eaters Hovinga et al [24]
5.16 4.68 230 1989-1990 US women - median age of 59 Hunter et al [25]
4.56 - 78 1993-1995 Michigan >= 50 years old Humphrey et al [26]
(geometric mean-males) 1.5 57 1994-1995 Great Lakes infrequent fish eaters Hanrahan et al [27]
(geometric mean - females) .9 42
3.7 - 66 1997 Great Lakes Ojibwa Indians Gerstenberger et al [7]

Table 2.

Blood Serum PCB concentrations (ppb) in children
Mean (arithmetic) Range Number tested Age (years) Date of testing Location Reference
2.1 0-23.3 285 4-5 1984-1985 Michigan Jacobson et al [28]
4.3 - 11 - 1984 US Schecter et al [29]


FIGURE 1

The following figure was not available in electronic format for conversion to HTML at the time of the preparation of this document. To obtain a hard copy of this figure, please contact:

Agency for Toxic Substances and Disease Registry
Division of Health Assessment and Consultation
Attn: Chief, Program Evaluation, Records, and Information Services Branch E-56
1600 Clifton Road NE, Atlanta, Georgia 30333

 

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