Skip directly to search Skip directly to A to Z list Skip directly to site content Skip directly to page options

Public Health Statement for Cresols

(Cresoles)

September 2008

CAS#: 1319-77-3

Public Health Statement PDF PDF Version, 72 KB


This Public Health Statement is the summary chapter from the Toxicological Profile for Cresols. It is one in a series of Public Health Statements about hazardous substances and their health effects. A shorter version, the ToxFAQs™, is also available. This information is important because these substances may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. For more information, call the ATSDR Information Center at 1 800-232-4636.

This public health statement tells you about cresols and the effects of exposure to these substances.

The Environmental Protection Agency (EPA) identifies the most serious hazardous waste sites in the nation. These sites are then placed on the National Priorities List (NPL) and are targeted for long-term federal clean-up activities. o-Cresol, m-cresol, p-cresol, and mixed cresols have been identified in at least 210, 22, 310, and 70 of the 1,678 current or former NPL sites, respectively. Although the total number of NPL sites evaluated for these substances is not known, the possibility exists that the number of sites at which cresols are found may increase in the future as more sites are evaluated. This information is important because these sites may be sources of exposure, and exposure to these substances may be harmful.

When a substance is released either from a large area, such as an industrial plant, or from a container, such as a drum or bottle, it enters the environment. Such a release does not always lead to exposure. You can be exposed to a substance only when you come in contact with it. You may be exposed by breathing, eating, or drinking the substance, or by skin contact.

If you are exposed to cresols, many factors will determine whether you will be harmed. These factors include the dose (how much), the duration (how long), and how you come in contact with it. You must also consider any other chemicals you are exposed to and your age, sex, diet, family traits, lifestyle, and state of health.


1.1 What are cresols?

Description

Three types (or isomers) of cresols exist: ortho-cresol, meta -cresol, and para-cresol; abbreviated as o-cresol, m-cresol, and p-cresol.

Pure cresols are solid, while mixtures tend to be liquid.

Cresols have a medicinal smell.

Uses

  • Manufacturing

Cresols are both manufactured chemicals and natural components in many foods. Large amounts of cresols are produced in the United States.

Cresols are used to manufacture other chemicals and as solvents.

  • Consumer products

Cresols kill microorganisms and are added to soaps as disinfectants.


1.2 What happens to cresols when they enter the environment?

Sources

Cresols are released to the environment during the burning of wood, coal, and fossil fuels, as well as from their manufacture and the use of products containing cresols.

Break down

  • Air

Cresols are quickly broken down in the air, usually within 1–2 days. They can also be removed from the air by rain.

  • Water

Cresols in water are degraded within days by microorganisms.

  • Soil

Cresols are degraded rapidly in soil by microorganisms, but a portion may move into groundwater.


1.3 How might I be exposed to cresols?

Air—primary source of exposure

The primary way you can be exposed to cresols is by breathing air containing them. Releases of cresols into the air occur from:

  • industries using or manufacturing cresols
  • automobile exhaust
  • cigarette smoke
  • wood and trash burning

A national emissions study conducted from 1990 to 1998 reported an average county-level concentration of 31.7 nanograms per cubic meter (ng/m3) for all cresol isomers combined.

Water

Cresols have been detected in surface waters and groundwater, but generally at low levels (approximately 1 microgram per liter [µg/L] or less).

Higher levels have been detected:

  • where petroleum spills have occurred
  • near hazardous waste sites
  • in industrial effluents

Workplace

A large number of workers are potentially exposed to cresols. Potential exposures occur in:

  • manufacture of cresols
  • chemical laboratories
  • coal gasification facilities
  • paint and varnish application
  • application of insulation lacquers to copper wires
  • wood-preserving facilities

Exposure may occur through breathing and dermal contact with contaminated air and/or liquid cresols or products containing cresols.

Food

Low levels of cresols have been found in some foods such as tomatoes, tomato ketchup, asparagus, cheeses, butter, bacon, and smoked foods.

Some drinks also contain cresols (coffee, black tea, wine, Scotch whisky, brandy, and rum).

Consumer products

Exposure may occur through accidental or intentional ingestion or contact of the skin with cleaners or disinfectants containing cresols.


1.4 How can cresols enter and leave my body?

Enter your body

  • Inhalation

There is no information to determine whether cresols can enter the bloodstream through your lungs if you breathe air contaminated with these substances.

  • Ingestion

Cresols in food or water may rapidly enter your body through the digestive tract.

  • Dermal Contact

Cresols may enter through your skin when you come into contact with liquids containing cresols.

Leave your body

Once in your body, cresols are transformed into other chemicals called metabolites. Most of these metabolites leave your body in the urine within 1 day.


1.5 How can cresols affect my health?

This section looks at studies concerning potential health effects in animal and human studies.

Humans

  • Inhalation

Brief exposures to 6 mg/m3 o-cresol in the air caused nose and throat irritation.

  • Oral

Ingestion of liquid products containing cresols can cause serious gastrointestinal damage and even death.

  • Dermal

Application of concentrated cresols to the skin can cause severe skin damage and even death.

Laboratory animals

  • Inhalation

Short-term exposure to cresols in air has caused irritation of the respiratory tract and muscle twitching.

  • Oral

Placing cresols in the stomach of animals by means of a feeding tube has caused muscle twitching and loss of coordination.

Eating food contaminated mostly with p-cresol or with a mixture of m- and p-cresol for 28 days or longer has caused lesions inside the nose of rats and mice; mice also developed lesions in the lungs and in the thyroid gland.

  • Dermal

Short-term application of cresols to the skin of animals has produced skin irritation.

Cancer

The EPA has determined that cresols are possible human carcinogens. The International Agency for Research on Cancer (IARC) has not classified cresols as to their carcinogenicity.


1.6 How can cresols affect children?

This section discusses potential health effects in humans from exposures during the period from conception to maturity at 18 years of age.

Effects in children

There are no studies of children exposed to cresols, but it is expected that children exposed to cresols will suffer the same effects observed in exposed adults.

There is a report of a baby who suffered serious damage to the skin, liver, and kidneys, went into a coma, and eventually died 4 hours after liquid cresol was accidentally spilled on his head.

Birth defects

Fetal toxicity and birth defects have been reported in animals given cresols. This generally occurred with doses that were also toxic to the mothers.

Breast milk

There is no information on levels of cresols in breast milk.


1.7 How can families reduce the risk of exposure to cresols?

Tobacco smoke

Cresols are components of tobacco smoke. Avoid smoking in enclosed spaces like inside the home or car in order to limit exposure to children and other family members.

Consumer products

Household cleaners and disinfectants containing cresols should be stored out of the reach of young children to prevent accidental poisonings and skin burns and follow manufacturer's directions on the label.


1.8 Is there a medical test to determine whether I have been exposed to cresols?

Detecting exposure

Cresols can be measured in blood and urine. Cresols are normal constituents of human urine.

Measuring exposure

A higher-than-normal concentration of cresols in the urine may suggest recent exposure to these substances or to substances that are converted to cresols in the body.

The detection of cresol and/or its metabolites in your urine cannot be used to predict the kind of health effects that might develop from that exposure.


1.9 What recommendations has the federal government made to protect human health?

The federal government develops regulations and recommendations to protect public health. Regulations can be enforced by law. The EPA, the Occupational Safety and Health Administration (OSHA), and the Food and Drug Administration (FDA) are some federal agencies that develop regulations for toxic substances. Recommendations provide valuable guidelines to protect public health, but cannot be enforced by law. The Agency for Toxic Substances and Disease Registry (ATSDR) and the National Institute for Occupational Safety and Health (NIOSH) are two federal organizations that develop recommendations for toxic substances.

Regulations and recommendations can be expressed as "not-to-exceed" levels. These are levels of a toxic substance in air, water, soil, or food that do not exceed a critical value. This critical value is usually based on levels that affect animals; they are then adjusted to levels that will help protect humans. Sometimes these not-to-exceed levels differ among federal organizations because they used different exposure times (an 8-hour workday or a 24-hour day), different animal studies, or other factors.

Recommendations and regulations are also updated periodically as more information becomes available. For the most current information, check with the federal agency or organization that provides it.

Some regulations and recommendations for cresols include the following:

Drinking water

EPA has not established drinking water standards and health advisories for cresols.

Workplace air

OSHA set a legal limit of 5 parts per million (ppm) cresols (all isomers) in air averaged over an 8-hour work day.


References

Agency for Toxic Substances and Disease Registry (ATSDR). 2008. Toxicological profile for Cresols. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.


Where can I get more information?

If you have questions or concerns, please contact your community or state health or environmental quality department or:

For more information, contact:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
1600 Clifton Road NE, Mailstop F-57
Atlanta, GA 30333
Phone: 1-800-CDC-INFO · 888-232-6348 (TTY)
Email: Contact CDC-INFO

ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.

Information line and technical assistance:
Phone: 888-422-8737

To order toxicological profiles, contact:
National Technical Information Service
5285 Port Royal Road
Springfield, VA 22161
Phone: 800-553-6847 or 703-605-6000

Disclaimer
Some PDF files may be electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the toxicological profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the toxicological profile home page, which also contains other important information about the profiles.

The information contained here was correct at the time of publication. Please check with the appropriate agency for any changes to the regulations or guidelines cited.

Contact Us:
  • Agency for Toxic Substances and Disease Registry
    4770 Buford Hwy NE
    Atlanta, GA 30341
  • 800-CDC-INFO
    (800-232-4636)
    TTY: (888) 232-6348
  • New Hours of Operation
    8am-8pm ET/Monday-Friday
    Closed Holidays
    Contact CDC-INFO
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Agency for Toxic Substances and Disease Registry, 4770 Buford Hwy NE, Atlanta, GA 30341
Contact CDC: 800-232-4636 / TTY: 888-232-6348

A-Z Index

  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #