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Nitrate/Nitrite Toxicity
Literature Cited

Course: WB 2342
CE Original Date: December 5, 2013
CE Expiration Date: December 5, 2015
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References

[AAP] American Academy of Pediatrics Committee on Nutrition. 1970. Infant methemoglobinemia: the role of dietary nitrate. Pediatrics 46(3):475-8.

Abadin HG, Murray HE, Wheeler JS. 1998. The use of hematological effects in the development of minimal risk levels. Regul Toxicol Pharmacol 28(1):61-6.

Alexander DD, Miller AJ, Cushing CA, Lowe KA. 2010. Processed meat and colorectal cancer: a quantitative review of prospective epidemiologic studies. Eur J Canc Prev. 19(5):328-41.

Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM. 2006. Dietary approaches to prevent and treat hypertension: a scientific statement form the American Heart Association. Hypertension 47:296-308.

Aquanno JJ, Khan KM, Dietzler DN. 1981. Accidental poisoning of two laboratory technologists with sodium nitrite. Clin Chem 27(6):1145-6.

Ash-Bernal R, Wise R, Wright SM. 2004. Acquired Methemoglobinemia: A Retrospective Series of 138 Cases at 2 Teaching Hospitals. Medicine 83(5):265-273.

Ashurst JV, Wasson MN, Hauger W, et al. 2010. Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. J Am Osteopath Assoc 110:16-20.

[ATSDR] Agency for Toxic Substances and Disease Registry. 2004. Interaction profile for cyanide, fluoride, nitrate, and uranium. Atlanta GA: US Department of Health and Human Services.

[ATSDR] Agency for Toxic Substances and Disease Registry. 2006. Interaction profile for atrazine, diethylatrazine, diazinon, nitrate, and simazine. Atlanta GA: US Department of Health and Human Services, Public Health Service.

[ATSDR] Agency for Toxic Substances and Disease Registry. 2011. Case studies in environmental medicine: taking an exposure history. Atlanta GA: US Department of Health and Human Services.

[ATSDR] Agency for Toxic Substances and Disease Registry. 2013. Case studies in environmental medicine: taking a pediatric exposure history. Atlanta GA: US Department of Health and Human Services.

Avery AA. 1999. Infantile methemoglobinemia: reexamining the role of drinking water nitrates. Environ Health Perspect 107(7):583-6.

Avner JR, Henretig FM, McAneney CM. 1990. Acquired methemoglobinemia-the relationship of cause to course of illness. Am J Dis Child 144:1229-1230.

Barrett JH, Parslow RC, McKinney PA, Law GR, Forman D. 1998. Nitrate in drinking water and the incidence of gastric, esophageal, and brain cancer in Yorkshire, England. Cancer Causes Control 9:153-9.

Berlin G, Brodin B, Hilden J. 1985.Acute dapsone intoxication: a case treated with continuous infusion of methylene blue, forced diuresis, and plasma exchange. J Toxicol Clin Toxicol 22:537-48.

Borniquel S, Jansson EA, Cole MP, Freeman BA, Lundberg JO. 2010. Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel disease. Free Radic Biol Med. 48(4):499-505.

Bradberry SM, Whittington RM, Parry DA, Vale JA. 1994. Fatal methemoglobinemia due to inhalation of isobutyl nitrite. J Toxicol Clin Toxicol 32(2):179-84.

Bradberry SM. 2003. Occupational methaemoglobinaemia: mechanisms of production, features, diagnosis and management including the use of methylene blue. Toxicol Rev 22(1):13-27.

Brender JD, Olive JM, Felkner M, Suarez L, Marckwardt W, Hendricks KA. 2004. Dietary nitrites and nitrates, nitrosatable drugs, and neural tube defects. Epidemiology 15(3):330-336.

Brender JD, Werler MM, Kelley KE, Vuong AM, Shinde MU, Zheng Q. 2011. Nitrosatable drug exposure during early pregnancy and neural tube defects in offspring. Am J Epidemiol 174(11):1286-1295.

Bruning-Fann CS, Kaneene JB. 1993. The effects of nitrate, nitrite and N-nitroso compounds on human health: a review. Vet Hum Toxicol 35(6):521-38.

Bucaretchi F, Miglioli L, Baracat EC, Madureira PR, Capitani EM, Vieira RJ. 2000. Acute dapsone exposure and methemoglobinemia in children: treatment with multiple doses of activated charcoal with or without the administration of methylene blue. J Pediatr (Rio J); 76(4):290-4. Portuguese.

Butler AR, Feelisch M. 2008. Therapeutic uses of inorganic nitrite and nitrate: from the past to the future. Circulation 117(16):2151-2159.

Cantor KP. 1997. Drinking water and cancer. Cancer Causes Control 8:292-308.

Carlsson S, Wiklund NP, Engstrand L, Weitzberg E, Lundberg JO. 2001. Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine. Nitric Oxide 5:580-586.

Carlstrom M, Persson AE, Larsson E, Hezel M, Scheffer PG, Teerlink T, et al. 2011. Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension. Cardiovasc Res. 89(3):574-85.

Casey DP, Beck DT, Braith RW. 2007. Systemic plasma levels of nitrite/nitrate (NOx) reflect brachial flow- mediated dilation responses in young men and women. Clin Exp Pharmacol Physiol. 34(12):1291-3.

[CDC] Centers for Disease Control and Prevention. 1995. A survey of the quality of water drawn from domestic wells in nine Midwest states. Atlanta GA: US Department of Health and Human Services.

[CDC] Centers for Disease Control and Prevention. 1997. Methemoglobinemia attributable to nitrite contamination of potable water through boiler fluid additives-New Jersey, 1992-1996. MMWR 46(09):202-4.

[CDC] Centers for Disease Control and Prevention. Fourth National Report on Human Exposure to Environmental Chemicals. Atlanta GA [updated Tables, 2013 March; accessed 2013 June]. Available from: http://www.cdc.gov/exposur ereport/pdf/FourthReport_UpdatedTables_Mar2013.pdf [PDF - 5.2 MB].

[CDC] Centers for Disease Control and Prevention. Drinking Water: Well Testing. Atlanta GA [updated 2010 May; accessed 2013 July]. Available from: http://www.cdc.gov/healthywater/dri nking/private/wells/testing.html.

[Census Bureau] US Census Bureau. Statistical Abstract of the United States 2012 (131st Ed). Washington DC [updated 2012 June 27; accessed 2012 July]. Available from: http://www.census.gov/compendia/statab/.

[Census Bureau] US Census Bureau. 2011. The American housing survey for the United States: 2009. Washington DC: US Government Printing Office.

Chan TY. 1996. Food-borne nitrates and nitrites as a cause of methemoglobinemia. Southeast Asian J Trop Med Public Health 27(1):189-92.

Chou TD, Gibran NS, Urdahl K, Lin EY, Heimbach DM, Engrav LH.1999. Methemoglobinemia secondary to topical silver nitrate therapy—a case report. Burns 25(6):549-552.

Coleman MD, Coleman NA. 1996. Drug-induced methaemoglobinaemia. Treatment issues. Drug Saf 14(6):394- 405.

Comly HH. 1945. Cyanosis in infants caused by nitrates in well water. JAMA 129:112.

Croen, LA, Todoroff K, Shaw GM. 2001. Maternal exposure to nitrate from drinking water and diet and risk of neural tube defects. Am J Epidemiol 153:325-31.

Cushing AH, Smith S. 1969. Methemoglobinemia with silver nitrate therapy of a burn: Report of a case. Jour of Pediat 74 (4):613-615.

Dabney BJ, Zelarney PT, Hall AH. 1990. Evaluation and treatment of patients exposed to systemic asphyxiants. Emerg Care Q 6(3):65-80.

DeBaun MR, Frei-Jones M, Vichinsky E. Hereditary methemoglobinemia. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia PA: Saunders Elsevier; 2011:chap 456.7.

Denshaw-Burke M. Updated 2013. Methemoglobinemia Workup. New York NY [accessed 2013 July 12]. Available from http://emedicine.medscape.com/article/204178.

Doel JJ, Benjamin N, Hector MP, Rogers M, Allaker RP. 2005. Evaluation of bacterial nitrate reduction in the human oral cavity. Eur J Oral Sci 113:14-19.

Dubrovsky NM, Hamilton PA. 2010. Nutrients in the Nation's streams and groundwater: National Findings and Implications: US Geological Survey Fact Sheet 2010-3078.

Duncan C, Dougall H, Johnston P, Green S, Brogan R, Leifert C, et al. 1995. Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat Med. 1(6):546-51.

Dusdieker LB, Dungy CI. 1996. Nitrates and babies: A dangerous combination. Contemp Pediatr 13(11):91- 102.

Dusdieker LB, Getchell JP, Liarakos TM, Hausler WJ, Dungy CI. 1994. Nitrate in baby foods: adding to the nitrate mosaic. Arch Pediatric Adolesc Med 148:490-94.

[EFSA] European Food Safety Authority. 2008. Nitrate in vegetables: scientific opinion of the panel on contaminants in the food chain. EFSA J. 689:1-79.

Eichholzer M, Gutzwiller F. 1998. Dietary nitrates, nitrites, and N-nitroso compounds and cancer risk: a review of the epidemiologic evidence. Nutr Rev 56:95-105.

Ellis M, Hiss Y, Shenkman L. 1992. Fatal methemoglobinemia caused by inadvertent contamination of a laxative solution with sodium nitrite. Isr J Med Sci 28(5):289-91.

[EPA] US Environmental Protection Agency. 1990a. Criteria document for nitrate/nitrite. Washington DC: US Environmental Protection Agency.

[EPA] US Environmental Protection Agency. 1990b. National pesticide survey: project summary. Washington DC: US Environmental Protection Agency.

[EPA] US Environmental Protection Agency. Reregistration Eligibility Decision: Inorganic Nitrate/Nitrite (Sodium and Potassium Nitrates). Washington DC [updated 1991 September]. Available from: http://www.epa.gov/oppsrrd1/REDs/factsheets/40 52fact.pdf [PDF - 44 KB].

[EPA] US Environmental Protection Agency. 2006. Ground Water and Drinking Water. Consumer Factsheet on: Nitrates/Nitrites. http://water.epa.gov/drink/contaminants/basicinformation/historical/upload/Archived-Consumer- Fact-Sheet-on-Nitrates-and-or-Nitrites.pdf [PDF - 194 KB].

[EPA] US Environmental Protection Agency. Integrated Risk Information System (IRIS) database. Nitrate (CASRN 14797-55-8). Washington DC [updated 2002 December 03; accessed July 2012]. Available from: http://cfpub.epa.gov/ncea/iris/index.cfm? fuseaction=iris.showQuickView&substance_nmbr=0076.

[EPA] US Environmental Protection Agency. Integrated Risk Information System (IRIS) database. Nitrite (CASRN 14797-65-0). Washington DC [updated 2002; accessed July 2013]. Available from: http://www.epa.gov/iris/subst/0078.htm.

[EPA] US Environmental Protection Agency. Basic Information about Nitrate in Drinking Water. Washington DC [updated 2012 May; accessed 2013 July]. Available from: http://water.epa.gov/drink/contaminants/basicinforon/nitrate.cfm.

EPA] US Environmental Protection Agency. Basic Information about Nitrite (Measured as Nitrogen] in Drinking Water. Washington DC [updated 2012 May; accessed 2013 July]. Available from: http://water.epa.gov/drink/contaminants/basicinformation/nitrite.cfm.

[EPA] US Environmental Protection Agency. Consumer factsheet on: nitrates/nitrites. Washington DC [updated 2004; accessed 2012]. Available from http://www.epa.gov/ogwdw000/pdfs/factsheet s/ioc/nitrates.pdf [PDF - 184 KB].

[EPA] US Environmental Protection Agency. Toxicity and Exposure Assessment for Children's Health Chemical Summary: Nitrates and Nitrites. Washington DC [updated 2007 May 22; accessed 2012 July]. Available from: http://www.epa.gov/teach/chem_summ/Nitrates_summary.pdf [PDF - 108 KB].

Evelyn K, Malloy H. 1938. Microdetermination of oxyhemoglobin, methemoglobin, and sulfhemoglobin in a single sample of blood. J Biol Chem 126:655.

Fan AM, Steinberg VE. 1996. Health implications of nitrate and nitrite in drinking water: An update on methemoglobinemia occurrence and reproductive and development toxicity. Regul Toxicol Pharmacol 123(11):35- 43.

[FDA] 21 CFR part 165. Sec. 165.110 Bottled water. Final Rule 2005. Electronic Code of Federal Regulations e-CFR Data is current as of July 22, 2013. [Last accessed July 24, 2013] http://www.ecfr.gov /cgi-bin/text-idx? c=ecfr&sid=e8b7a7992ba5413d50490c47e2f2e69b&rgn=div5&view=text&node=21:2.0.1.1.38&idno=21

Federal Register; 70 FR 33694 June 9, 2005 - Beverages: Bottled Water Final Rule

[Federal Register: June 9, 2005 (Volume 70, Number 110)]
[Rules and Regulations]
[Page 33694-33701]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr09jn05-6]

[FDA] Code of Federal Regulations. (2003). Title 21, Pts. 110-Current Good Manufacturing Practice in Manufacturing, Packing, or Holding Human Food, 170-Food Additives, and Section 172.177-Sodium nitrite used in processing smoked chub. Washington DC: Office of Federal Register National Archives and Records Administration [updated 2013 April 1; accessed 2013 July 24]. Available from: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=172.175.

Fernandez-Frackelton M, Bocock J. Cyanosis. 2009. In: Marx JA, Hockberger RS, Walls RM, et al., eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 7th ed. Philadelphia PA: Mosby Elsevier. chap 29.

Flomenbaum NE, Goldfrank LR, Hoffman RS, Howland MA, Lewin NA, Nelson LS, eds. 2006. Methemoglobin inducers in Toxicologic Emergencies. New York: McGraw-Hill Publishers.

Gago B, Nystrom T, Cavaleiro C, Rocha BS, Barbosa RM, Laranjinha J, et al. 2008. The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions. Free Radic Biol Med 45:404-412.

Gebara B, Goetting MM. 1994. Life-threatening methemoglobinemia in infants with diarrhea and acidosis. Clin Pediatr 33:370-3.

Geffner ME, Powars DR, Choctaw WT. 1981. Acquired methemoglobinemia. West J Med 134(1):7-10.

Gilchrist M, Winyard PG, Benjamin N. 2010. Dietary nitrate - good or bad? Nitric Oxide 22:104-109.

Gitto E, Reiter RJ, Karbownik M, Tan DX, Gitto P, Barberi S, et al. 2002. Causes of oxidative stress in the pre- and perinatal period. Biol Neonate 81:146-157.

Gladwin MT, Hunter CJ, Dejam A, Blood AB, Shields H, Kim-Shapiro D, et al. 2004. Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nat Med 10:1122-1127.

Goluboff N, Wheaton R. 1961. Methylene blue induced cyanosis and acute hemolytic anemia complicating the treatment of methemoglobinemia. J Pediatr 58:86-9.

Gordon MC. 2012. Maternal Physiology. In: Gabbe SG, Niebyl JR, Galan H, Jauniaux ER, Landon M, Simpson JL et al, editors. Obstetrics: Normal and Problem Pregnancies. 6th ed. Philadelphia PA: Saunders Elsevier. Chapter 3, Pages 51-53.

Gowans WJ. 1990. Fatal methaemoglobinaemia in a dental nurse. A case of sodium nitrite poisoning. Br J Gen Pract 40:470-1.

Grant W, Steele G, Isiorho, SA. 1995. Spontaneous abortions possibly related to ingestion of nitrate- contaminated well water-LaGrange County, Indiana, 1991-1994. MMWR 45:569-72. Atlanta GA [updated 1996 July 04; accessed 2012 July]. Available from: http://www.cdc.gov/mmwr/preview/mmwrhtml/00042839 .htm.

Green LC, Deluzuriaga KR, Wagner DA, Rand W, Istfan N, Young VR, et al. 1981. Nitrate Biosynthesis in Man, Proceedings from the National Academy of Science USA. Biol Sci 78:7764-7768.

Greer FR, Shannon M. 2005. Infant methemoglobinemia: the role of dietary nitrate in food and water. Pediatrics 116 (3):784-786.

Grethlein SJ, Besa EC. Blood Substitutes. Medscape. New York NY [updated 2012 June 25; accessed 2013 October 22]. Available from: http://emedicine.medscape.com/article/207801-overview.

Hannerz J, Greitz D. 1992. Cerebrospinal fluid pressure and venous pressure in "dynamite" headache and cluster headache attacks. Headache. 32:436-438.

Hanukoglu A, Danon PN. 1996. Endogenous methemoglobinemia associated with diarrheal disease in infancy. J Pediatr Gastroenterol Nutr 23:1-7.

Harris JC, Rumack BH, Peterson RG, McGuire BM. 1979. Methemoglobinemia resulting from absorption of nitrates. JAMA 242(26):2869-71.

Harrison MR. 1977. Toxic methemoglobinemia: a case of acute nitrobenzene and aniline poisoning treated by exchange transfusion. Anaesthesia 32:270-2.

Harvey JW, Keitt AS. 1983. Studies of the efficacy and potential hazards of methylene blue therapy in aniline-induced methaemoglobinaemia. Br J Haematol 54:29-41.

Harvey M, Cave G, Chanwai G. 2010. Fatal methaemoglobinaemia induced by self-poisoning with sodium nitrite. Emergency Medicine Australasia 22:463-465.

Haymond S, Cariappa R, Eby CS, Scoot MG. 2005. Laboratory assessment of oxygenation in methemoglobinemia. Clinical Chem 51 (2):434-444.

Henretig FM, Gribetz B, Kearney T. 1988. Interpretation of color change in blood with varying degree of methemoglobinemia. Clin Toxicol 26(5-6):293-301.

Hill MJ. 1999. Nitrate toxicity: myth or reality? Br J Nutr 81(5):343-4.

Hogstedt C, Axelson O. 1977.Nitroglycerine-nitroglycol exposure and the mortality in cardiocerebrovascular disease among dynamite workers. J Occup Med 19:675.

Holmes AS, Chirkov YY, Willoughby SR, Poropat S, Pereira J, Horowitz JD. 2005. Preservation of platelet responsiveness to nitroglycerine despite development of vascular nitrate tolerance. Br J Clin Pharmacol 60:355-363.

Hord NG. 2011. Dietary Nitrates, Nitrites, and Cardiovascular Disease. Curr Atheroscler Rep 13:484-492.

Hord NG, Ghannam JS, Garg HK, Berens PD, Bryan NS. 2010. Nitrate and nitrite content of human, formula, bovine, and soy milks: implications for dietary nitrite and nitrate recommendations. Breastfeed Med 6(6):393- 9. Epub.

Hord NG, Tang Y, Bryan NS. 2009. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 90(1):1-10.

Huber JC, Brender JD, Zheng Q, Sharkey JR, Vuong AM, Shinde MU. 2013. Maternal dietary intake of nitrates, nitrites and nitrosamines and selected birth defects in offspring: a case-control study. Nutrition Journal 12:34. Available from: http://www.nutritionj.com/content/12/1/34.

Hunault CC, van Velzen AG, Sips AJ, Schothorst RC, Meulenbelt J. 2009. Bioavailability of sodium nitrite from an aqueous solution in healthy adults. Toxicol Lett 190:48-53.

Hunter L, Gordge L, Dargan PI, Wood, DM. 2011. Methaemoglobinaemia associated with the use of cocaine and volatile nitrites as recreational drugs: a review. Br J Clin Pharmacol 72(1): 18-26.

[IARC] 2010. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Ingested Nitrate and Nitrite and Cyanobacterial Peptide Toxins Volume 94 Lyon FR [updated 2010; accessed 2013 July]. Available from: http://monographs.iarc.fr/ENG/Monographs/vol94/.

Jaffe ER, Hultquist DE. 1995. Cytochrome b5 reductase deficiency and enzymopenic hereditary methemoglobinemia. In: Scriver CR, Beaudet AL, Sly WS, editors. The metabolic and molecular basis of inherited disease. 7th ed. New York NY: McGraw-Hill. p. 2267-80.

Jansson EA, Huang L, Malkey R, Govoni M, Nihlen C, Olsson A, et al. 2008. A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis. Nat Chem Biol 4:411-417.

Jiang R, Camargo Jr CA, Varraso R, Paik DC, Willett WC, Barr RG. 2008. Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women. Am J Clin Nutr. 87(4):1002-8.

Johnson CJ, Kross BC. 1990. Continuing importance of nitrate contamination of groundwater and wells in rural areas. Am J Ind Med 18(4):449-56.

Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, et al. 2010. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension 56 (2):274-281.

Kath MA, Shupp JW, Matt SE, Shaw JD, Johnson LS, Pavlovich AR, et al. 2011. Incidence of methemoglobinemia in patients receiving cerium nitrate and silver sulfadiazine for the treatment of burn wounds: A burn center's experience. Wound Rep Reg 19:201-204.

Keating JP, Lell ME, Strauss AW, Zarkowsky H, Smith GE. 1973. Infantile methemoglobinemia caused by carrot juice. N Engl J Med 288(16):824-6.

Khavandi A, Whitaker J, Gonna H, et al. 2008. Serotonin toxicity precipitated by concomitant use of citalopram and methylene blue. Med. J. Aust 189: 534-535.

Kirsch IR, Cohen HJ. 1980. Heinz body hemolytic anemia from the use of methylene blue in neonates. J Pediatr 96:276-8.

Knobeloch L, Salna B, Hogan A, Postle J, Anderson H. 2000. Blue babies and nitrate-contaminated well water. Environ Health Perspect 108(7):675-8.

Koenig A, Roegler C, Lange K, Daiber A, Glusa E, Lehmann J. 2007. NO donors, Part 16: investigations on structure-activity relationships of organic mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent vasodilator. Bioorg Med Chem Lett 17:5881-5885.

Kostraba JN, Gay EC, Rewers M, Hamman RF. 1992. Nitrate levels in community drinking waters and risk of IDDM. An ecological analysis. Diabetes Care 15(11):1505-8.

Kross BC, Ayebo AD, Fourtes LJ. 1992. Methemoglobinemia: nitrate toxicity in rural America. Am Fam Physician 46:183-88.

Kurtzman TL, Otsuka KN, Wahl RA. 2001. Inhalant abuse in adolescents. J Adolesc Health 28:170-80.

Lacy BW, Ditzler TF. 2007. Inhalant Abuse in the Military: An Unrecognized Threat. Military Medicine 172:388- 392.

Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E. 2011. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metabol 13(2):149-59.

Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. 2010. Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med. 48(2):342-7.

Lauer T, Heiss C, Balzer J, Kehmeier E, Mangold S, Leyendecker T, et al. 2008. Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise. Basic Res Cardiol. 103(3):291-7.

Leaf CD, Wishnok JS, Tannenbaum SR. 1989. L-Arginine is a precursor for nitrate biosynthesis in humans. Biochem Biophys Res Commun 163:1032-1037.

Lebby T, Roco JJ, Arcinue EL. 1993. Infantile methemoglobinemia associated with acute diarrheal illness. Am J Emerg Med 11:471-2.

Lopez-Shirley K, Zhang F, Gosser D, Scott M, Meshnick SR. 1994. Antimalarial quinones: redox potential dependence of methemoglobin formation and heme release in erythrocytes. Lab Clin Med 123(1):126-30.

Lu HC, Shih RD, Marcus S, Ruck B, Jennis T. 1998. Pseudomethemoglobinemia. Arch Pediatr Adolesc Med 152:803-5.

Lundberg JO, Carlstrom M, Larsen FJ, Weitzberg E. 2011. Roles of dietary inorganic nitrate in cardiovascular health and disease. Cardiovasc Res. 89(3):525-32.

Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, et al. 2009. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol. 5(12):865-9.

Lundberg JO, Weitzberg E, Cole JA, Benjamin N. 2004. Nitrate, bacteria and human health. Nat Rev Microbiol 2(7):593-602.

Lundberg JO, Weitzberg E, Gladwin MT. 2008. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7 (2):156-167.

Mack RB. 1982. The "blue" people with "chocolate" blood-methemoglobinemia. N C Med J 43(4):292-3.

Mackerness CW, Keevil CW. 1991. Origin and significance of nitrite in water. In: Hill MJ, editor. Nitrates and nitrites in food and water. Chichester England:Ellis Horwood.

Macknet MR, Allard M, Applegate RL 2nd, Rook J. 2010. The accuracy of noninvasive and continuous total hemoglobin measurement by pulse CO-Oximetry in human subjects undergoing hemodilution. Anesth Analg 111 (6):1424-6.

Macknet MR, Kimball-Jones PL, Applegate RL, Martin RD, Allard MW. 2007. Noninvasive Measurement of Continuous Hemoglobin Concentration via Pulse CO-Oximetry. Anesthesiology 107: A1545.

Manassaram DM, Backer LC, Moll DM. 2006. A Review of Nitrates in Drinking Water: Maternal Exposure and Adverse Reproductive and Developmental Outcomes. Environmental Health Perspectives 114 (3):320-327.

Mansouri A, Lurie AA. 1993. Concise review: Methemoglobinemia. Am J Hematol 42:7-12.

Matthews PJ. 1995. Co-oximetry. Resp Care Clin N Am 1:47-68.

McDonagh EM, Bautista JM, Youngster I, Altman RB, Klein TE. 2013. PharmGKB summary: methylene blue pathway. Pharmacogenetics and Genomics 23 (9):498-508.

McGoldrick MD, Bailie GR. 1995. Severe accidental dapsone overdose. Am J Emerg Med 13(4):414-5.

McKenzie SB. 2010. Clinical Laboratory Hematology, 2nd ed. 2010, Prentice Hall, Chapters 6 and 10. E- textbook STAT!Ref.

McKnight GM, Duncan CW, Leifert C, Golden MH. 1999. Dietary nitrate in man: Friend or foe? Br J Nutr 81 (5):349-58.

Mensinga TT, Speijers GJA, Meulenbelt J. 2003. Health implications of exposure to environmental nitrogenous compounds. Toxicol Rev 22(1):41-51.

Mier RJ. 1988. Treatment of aniline poisoning with exchange transfusion. Clin Toxicol 26:357-64.

Mowbray M, McLintock S, Weerakoon R, Lomatschinsky N, Jones S, Rossi AG, et al. 2009. Enzyme-independent NO stores in human skin: quantification and influence of UV radiation. J Investig Dermatol 129(4):834-42.

Nelson KA, Hostetler MA. 2003. An Infant with Methemoglobinemia. Pediatric Rounds Series in Hospital Physician February:31-38.

Nolan BT, Hitt KJ, Ruddy BC. 2002. Probability of nitrate contamination of recently recharged ground waters in the conterminous United States. Environ Sci Technol 36(10):2138-45.

Norat T, Bingham S, Ferrari P, Slimani N, Jenab M, Mazuir M, et al. 2005. Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Canc Inst 97(12):906-16.

[NRC] National Research Council, Committee on Toxicology. 1995. Nitrate and nitrite in drinking water. Washington DC: National Academies Press.

Ohashi K, Yukioka H, Hayashi M, Asada A. 1998. Elevated methemoglobin in patients with sepsis. Acta Anaesthesiol Scand 42:713-6.

Olsen ML, McEvoy GK. 1981. Methemoglobinemia induced by topical anesthetics. Am J Hosp Pharmacol 38:89- 93.

Omar SA, Artime E, Webb AJ, 2012. A comparison of organic and inorganic nitrates/nitrites. Nitric Oxide 26 (4):229-240.

Oplander C, Volkmar CM, Paunel-Gorgulu A, van Faassen EE, Heiss C, Kelm M, et al. 2009. Whole body UVA irradiation lowers systemic blood pressure by release of nitric oxide from intracutaneous photolabile nitric oxide derivates. Circ Res. 105(10):1031-40.

Osterhoudt KC. Methemoglobinemia. 2001. In: Ford MD, Delaney KA, Ling LJ, Erickson T, editors. Clinical toxicology. 1st ed. Philadelphia PA: WB Saunders Company. p. 214-6.

Panesar NS. 2008. Downsides to the nitrate-nitrite-nitric oxide pathway in physiology and therapeutics? Nat Rev 7(8):710.

Pannala AS, Mani AR, Spencer JP, Skinner V, Bruckdorfer KR, Moore KP, et al. 2003. The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. Free Radic Biol Med 34:5765-84.

Park CM, Nagel RL. 1984. Sulfhemoglobinemia: clinical and molecular aspects. N Engl J Med 310:1579-84.

Parslow RC, McKinney PA, Law GR, Staines A, Williams R, Bodansky HJ. 1997. Incidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: an ecological analysis. Diabetologia 40(5):550-6.

Pennington J. 1998. Dietary exposure models for nitrates and nitrites. Food Contr 9:385-95.

Petersson J, Phillipson M, Jansson EA, Patzak A, Lundberg JO, Holm L. 2007. Dietary nitrate increases gastric mucosal blood flow and mucosal defense. Am J Physiol 292(3):G718-24.

Powlson DS, Addiscott TM, Benjamin N, Cassman KG, de Kok TM, van Grinsven H, et al. 2008. When does nitrate become a risk for humans? J Environ Qual 37(2):291-5.

Prasad R, Singh R, Mishra OP, Pandey M. 2008. Dapsone induced methemoglobinemia: Intermittent vs continuous intravenous methylene blue therapy. Indian J Pediatr 75(3):245-7.

Price D. Methemoglobinemia. 1998. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS, editors. Goldfrank's toxicologic emergencies. 6th ed. Old Tappan NJ: Appleton & Lange. p. 1507- 23.

Rahman MM, Mogni Mowla SG, Rahim A, Chowdhury FR, Jahan S, Hasan MN. 2012. Severe haemolytic anaemia due to ingestion of naphthalene (mothball) containing coconut oil. J Coll Physicians Surg Pak 22(11):740-1.

Ralston AC, Webb RK, Runciman WB. 1991. Potential error in pulse oximetry: III. Effects of interference, dyes, dyshaemoglobins and other pigments. Anaesthesia 46:291-5.

Ramsay RR, Dunford C, Gillman PK, et al. 2007. Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Br J Pharmacol152: 946-951.

Rao GS, Osborn JC, Adatia MR. 1982. Drug-nitrite interactions in human saliva: effects of food constituents on carcinogenic N-nitrosamine formation. J Dent Res. 61(6):768-71.

Rehman HU. Methemoglobinemia. 2001. West J Med 175:193-6.

Reigart JR, Trammel HL, Lindsey JM. 1982. Repetitive doses of activated charcoal in dapsone poisoning in a child. J Toxicol Clin Toxicol 19(10):1061-6.

Reynolds KA. The prevalence of nitrate contamination in the United States. Water Conditioning and Purification. Washington DC [updated 2002 January; accessed July 2012]. Available from: http://www.wcponline.com/ArchiveNewsView.cfm?pkArticleID=1330&AT=T.

Rhodes P, Leone AM, Francis PL, Struthers AD, Moncada S, Rhodes PM. 1995. The L-arginine: nitric oxide pathway is the major source of plasma nitrite in fasted humans. Biochem Biophys Res Commun 209:590-596.

Richardson G, Hicks SL, O'Byrne S, Frost MT, Moore K, Benjamin N, et al. 2002. The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans. Nitric Oxide 7:24- 29.

Ritchey AK, Keller FG, O'Brien SH. 2012. Hematologic Manifestations of Childhood Illness in Hoffman: Hematology: Basic Principles and Practice, 6th ed. Saunders, Chap 154: pages 2161-2162.

Rocha BS, Gago B, Pereira C, Barbosa RM, Bartesaghi S, Lundberg JO, Radi R, Laranjinha J. 2011. Dietary nitrite in nitric oxide biology: a redox interplay with implications for pathophysiology and therapeutics. Curr Drug Targets 12(9):1351-1363.

Rosen PJ, Johnson C, McGehee WG, Beutler E. 1971. Failure of methylene blue treatment in toxic methemoglobinemia. Ann Intern Med 75:83-6.

Rosenman K. 2007. Occupational heart disease. In: Rom W and Markowitz S eds. Environmental and occupational medicine, 4th ed. Hagerstown, MD: Lippincott Williams & Wilkins. pp. 684-5.

Rowley GA. Carrots from the Everglades. 1973. N Engl J Med 289(2):109.

RuDusky BM. 2001. Acute myocardial infarction secondary to coronary vasospasm during withdrawal from industrial nitroglycerin exposure - a case report. Angiology 52:143-144.

Sager S, Grayson GH, Feig SA. 1995. Methemoglobinemia associated with acidosis of probable renal origin. J Pediatr 126:59-61.

Saito T, Takeichi S, Yukawa N, Osawa M. 1996. Fatal Methemoglobinemia Caused by Liniment Solutions Containing Sodium Nitrite. Journal of Forensic Sciences 41(1): 169-171.

Saito T, Takeichi S, Osawa M, Yukawa N, Huang X-L. 2000. A case of fatal methemoglobinemia of unknown origin but presumably due to ingestion of nitrate. Int J Legal Med 113(3):164-7.

Sanchez-Echaniz J, Benito-Fernandez J, Mintegui-Raso S. 2001. Methemoglobinemia and consumption of vegetables in infants. Pediatrics 107(5):10248.

Santamaria P. 2006. Nitrate in vegetables: toxicity, content, intake and EC regulation. J Sci Food Agric 86:10-17.

Savino F, Maccario S, Guidi C, Castagno E, Farinasso D, Cresi F, et al. 2006.Methemoglobinemia Caused by the Ingestion of Courgette Soup Given in Order to Resolve Constipation in Two Formula-Fed Infants. Ann Nutr Metabl 50:368-371.

Schmitter CR. 1975.Sulfhemoglobinemia and methemoglobinemia: Uncommon causes of cyanosis. Anesthesiology 43:586-7.

Schuhmacher S, Schulz E, Oelze M, Konig A, Roegler C, Lange K, et al. 2009. A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomena. Br J Pharmacol 158:510- 520.

Shearer LA, Goldsmith JR, Young C, Kearns OA, Tamplin BR. 1972. Methemoglobin levels in infants in an area with high nitrate water supply. Am J Public Health 62(9):1174-80.

Shuval HI, Gruener N. 1992. Epidemiological and toxicological aspects of nitrates and nitrites in the environment. Am J Public Health 62(8):1045-52.

Sillery JJ, Lichenstein R, Barrueto F Jr, Teshome G. 2009. Hemolytic anemia induced by ingestion of paradichlorobenzene mothballs. Pediatr Emerg Care 25(4):252-4.

Skold A, Cosco DL, Klein R. 2011. Methemoglobinemia: Pathogenesis, Diagnosis, and Management. Southern Medical Journal 204(11):757-761.

Smith RP. 1991. Toxic responses of the blood. In: Amdur MO, Doull J, Klaassen CD, editors. Casarett and Doull's toxicology: the basic science of poisons. New York NY: Pergamon Press. p. 257-81.

Sobko T, Huang L, Midtvedt T, Norin E, Gustafsson LE, Norman M, et al. 2006. Generation of NO by probiotic bacteria in the gastrointestinal tract. Free Radic Biol Med. 41(6):985-91.

Sobko T, Marcus C, Govoni M, Kamiya S. 2010. Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers. Nitric Oxide. 22(2):136-40.

Squillace P, Scott J, Moran M, Nolan B T, Kolpin D. 2002. VOCs, Pesticides, Nitrate, and Their Mixtures in Groundwater Used for Drinking Water in the United States. Environ Sci Technol. 36:1923-30.

Stayner LT, Dannenberg AL, Thun M, Reeve G, Bloom TF, Boeniger M, et al. 1992. Cardiovascular mortality among munitions workers exposed to nitroglycerine and dinitrotoluene. Scand J Work Environ Health 18(1):34- 43.

Steinhorn RH. 2008. Evaluation and management of the cyanotic neonate. Clin Pediatr Emerg Med 9(3): 169-175.

Tabacova S, Balabaeva L, Little RE. 1997. Maternal exposure to exogenous nitrogen compounds and complications of pregnancy. Arch Environ Health 52(5):341-7.

Tabacova S, Baird DD, Balabaeva L. 1998. Exposure to oxidized nitrogen: lipid peroxidation and neonatal health risk. Arch Environ Health 53:214-221.

Thatcher GR, Nicolescu AC, Bennett BM, Toader V. 2004. Nitrates and NO release: contemporary aspects in biological and medicinal chemistry. Free Radic Biol Med 37:1122-1143.

Tricker AR, Preussmann R. 1991. Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential. Mutat Res 259:277-89.

Turner MD, Karlis V, Glickman RS. 2007. The Recognition, Physiology, and Treatment of Medication-Induced Methemoglobinemia: A Case Report. Anesth Prog 54(3):115-117.

[USDA] US Department of Agriculture, Food Safety and Inspection Service (FSIS) Directive 7120.1, Safe and Suitable Ingredients Used in The Production of Meat, Poultry, and Egg Products, Revision 13. Washington DC [dated 2012 November 21; accessed 2012 November]. Available from http://www.fsis.usda.gov/OPPDE/rdad/FSISD irectives/7120.1.pdf [PDF - 359 KB].

van Faassen EE, Bahrami S, Feelisch M, Hogg N, Kelm M, Kim-Shapiro DB, et al. 2009. Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev. 29(5):683-741.

Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, et al. 2010. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate- intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 299(4):R1121-31.

Van Loon AJ, Botterweck AA, Goldbohm RA, Brants HA, van Klaveren JD, van den Brandt PA. 1998. Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study. Br J Cancer 78:129-35.

Virtanen SM, Jaakkola L, Rasanen L, Ylonen K, Aro A, Lounamaa R, et al. 1994. Nitrate and nitrite intake and the risk for type 1 diabetes in Finnish children. Childhood Diabetes in Finland Study Group. Diabet Med 11(7):656-62.

Vittozzi L. 1992. Toxicology of nitrates and nitrites. Food Addit Contam 9(5):579-85.

Walker R. 1996. The metabolism of dietary nitrites and nitrates. Biochem Soc Trans 24(3):780-5.

Ward MH, Kilfoy BA, Weyer PJ, Anderson KE, Folsom AR, Cerhan JR. 2010. Nitrate intake and the risk of thyroid cancer and thyroid disease. Epidemiol (Cambridge, Mass) 21(3):389-95.

Ward MH, Mark SD, Cantor KP, Weisenburger DD, Correa-Villasenor A, Zahm SH. 1996. Drinking water nitrate and the risk of non-Hodgkin's lymphoma. Epidemiology 7(5):465-71.

[WCRF] World Cancer Research Fund. 2007. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Second Expert Report, 2007. London UK [updated 2009 February 26; accessed 2012 November 29]. Available from: http://www.dietand cancerreport.org/cancer_resource_center/er_full_report_english.php.

Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, et al. 2008. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension 51:78--790.

Weitzberg E, Hezel M, Lundberg JO. 2010. Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care. Anesthesiology 113(6):1460-75.

Wentworth P, Roy M, Wilson B, Padusenko J, Smeaton A, Burchell N. 1999. Toxic methemoglobinemia in a 2- year-old child. Lab Med 30(5):311-5.

Wenzel P, Hink U, Oelze M, Seeling A, Isse T, Bruns K, et al. 2007. Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/-mice. Br J Pharmacol 150:526 -533.

[WHO] World Health Organization. 2011a. Guidelines for drinking-water quality, fourth edition. Nitrates and Nitrites, pages 398-403. Geneva CH [accessed 2013 March 6]. Available from: http://www.who.int/water_s anitation_health/dwq/chemicals/nitratesnitrite/en/

[WHO] World Health Organization. 2011b. Nitrate and Nitrite in Drinking-water :Background document for development of WHO Guidelines for Drinking-water Quality, pages 10-13. Geneva CH [accessed 2013 March 6]. Available from: http://www.who.int/wa ter_sanitation_health/dwq/chemicals/nitratenitrite2ndadd.pdf [PDF - 325 KB].

Wright RO, Woolf AD, Shannon MW, Magnani B. 1998. N-acetylcysteine reduces methemoglobin in an in-vitro model of glucose-6-phosphate dehydrogenase deficiency. Acad Emerg Med 5(3):225-9.

Wright RO, Lewander WJ, Woolf AD. 1999. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 34(5):646-56.

Wu LT, Schlenger WE, Ringwalt, CL. 2005. Use of nitrite inhalants ("poppers") among American Youth. J Adolesc Health 37(1):52-60.

Xu G, Song P, Reed PI. 1992. The relationship between gastric mucosal changes and nitrate intake via drinking water in a high-risk population for gastric cancer in Moping County, China. Eur J Cancer Prev 1 (6):437-43.

Zeman CL, Kross B, Vlad M. 2002. A nested case-control study of methemoglobinemia risk factors in children of Transylvania, Romania. Environ Health Perspect 110(8):817-22.

Zorc JJ, Kanic Z. 2001. A cyanotic infant: true blue or otherwise? Pediatr Ann 30(10):597-601.

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