HEALTH CONSULTATION

NAVAL AIR STATION PATUXENT RIVER
(a/k/a PATUXENT NAVAL AIR STATION
PATUXENT, ST. MARY'S COUNTY, MARYLAND

CONCLUSIONS

The consumption limit currently in effect at NAS Patuxent River for fish taken from ponds on base is protective of all persons, even sensitive populations including pregnant women, embryos, fetuses, lactating mothers, and breast-fed neonates and infants.

RECOMMENDATION

ATSDR recommends continuation of the existing consumption limit Persons consuming fish harvested from any of the six NAS Patuxent River ponds should eat no more than two eight-ounce portions per month and 19 such meals per year for no more than seven years, effectively a lifetime limit of 133 fish meals. This would include men as well as women. Adverse reproductive effects in males have been seen in animal studies from both PCBs and DDT, although at higher concentrations than those for reproductive and developmental effects cited in this consultation for females in animal studies.

REFERENCES

1. ATSDR, Final Public Health Assessment for Naval Air Station, Patuxent River, August 18, 1997.
   
   
2. ATSDR, Final Public Health Assessment for Naval Air Station PAtuxent River, August 18, 1997, p.11 and Appendix C.
   
   
3. ATSDR, Toxicological Profile for Polychlorinated Biphenyls (Update) September 1997 p. 287.
   
   
4. Ibid. p. 2.
   
   
5. Ibid. p. 287.
   
   
6. Ibid. p. 345.
   
   
7. Ibid. p. 83
   
   
8. Ibid. p. 83
   
   
9. Arnold DL, Mes J, Bryce F et all. 1990.  A Pilot Study on the Effects of Arcolor 1254 Ingestion by Rhesus and Cynomologus Monkeys as a Model for Human Ingestion of PCBs, Food Chem Toxicol 28:847-857.
   
   
10. Arnold DL, Bryce F, Karpinski K et al. 1993. Toxicological Consequences of Arcolor 1254 Ingestion by Female Rhesus (Macaca mulatta) Monkey, Food Chem Toxicol 31: 799-824
    
    
11. ATSDR, Toxicological Profile for Polychlorinated Biphenyls (Update) September 1997 p. 304.
    
    
12. Ibid. p. 84.
    
    
13. Schwartz PM, Jacobson SW, Fein G, et al. 1983. Lake Michigan Fish Consumption as a Source of Polychlorinated Biphenyls in Human Cord Serum, Maternal Serum and Milk, Am J Public Health, 73: 293.
    
    
14. ATSDR, Toxicological Profile for Polychlorinated Biphenyls (Update) September 1997 p. 287.
    
    
15. Fein CG, Jacobson SW, Schwartz PM, et al. 1984. Prenatal Exposure to Polychlorinated Biphenyls: Effects on Birth Size and Gestational Age, J Pediatr, 105:315
    
    
16. Jacobson JL, Jacobson SW, Humphrey HEB. 1990. Effects of In Utero Exposure to Polychlorinated Biphenyls and Related Contaminants on Cognitive Functioning in Young Children, J Pediatr, 116: 38-45.
    
    
17. Jacobson JL and Jacobson SW. 1996. Intellectual Impairment in Children Exposed to Polychlorinated Biphenyls in Utero, New England J Med, 335: 783-789.
    
    
18. Humphrey, HEB, 1988. Chemical contaiminanats in the Great Lakes: The Human Health Aspect. In: Evans MS, ed. Toxic Contaminants and Ecosystem Health: A Great Lakes Focus. New York, NY: John Wiley and Sons, 153-165
    
    
19. Paneth N, 1991. Human Reproduction After Easting PCB-Contaiminated Fish, Health Environ Digest. 5: 4.
    
    
20. Kimbrough RD, 1995 Critical Reviews in Toxicology, 25: 133-163.
    
    
21. ATSDR, Final Public Health Assessment for Navala Air Station Patuxent River, August 18, 1997, p. 11.
    
    
22. ATSDR, Toxicological Profile for 4-4'-DDT, 4-4'-DDE, and 4-4'-DDD (Update) May 1994, p. 119.
    
    
23. Ibid. p. 95.
    
    
24. Ibid. p. 95.
    
    
25. Ibid. p. 32.
    
    
26. Leoni V, Fabiani L, Marinelli G, Et al. 1989. PCB and Other Organochlorine Compunds in Blood of Women with or without Miscarriage: A Hypothesis of Correlation. Ecotoxic Environ Safety 17: 1-11.
    
    
27. Rom, M, Cucos B, Rosen B et al. 1988. Maternal and Fetal Serum Levels of Organochlorine Compounds in Cases of Premature Rupture of Membranes. Acta Obstet Gynacol Scand 67: 695-697.
    
    
28. ATSDR, Toxicological Profile for 4-4'-DDT, 4-4'-DDE, and 4-4'-DDD (Update) May 1994, p. 119.
    
    
29. Ibid. p. 34.
    
    
30. Keplinger M, Deichmann W. Sala F. 1970. Effects of Combinations of Pesticides on Reproduction in Mice. In: Deichmann W, ed. Pesticde Symposia. 6th-7th Int-Am Conf Toxicol Occup Med, Miami, FL, 125-138.
    
    
31. ATSDR, Toxicological Profile for 4-4'-DDT, 4-4'-DDE, and 4-4'-DDD (Update) May 1994, p. 35.
    
    
32. Ibid. p. 35-38.
    
    
33. Eriksson P, Nordberg A. 1986. The Effects of DDT, DDOH-Palmitic Acid and Chlorinated Paraffin on Muscarinic Receptors and the Sodium-Dependent Choline Uptake in the Central Nervous System of Immature Mice. Toxicol Appl Pharmacol 85: 121-127.
    
    
34. Eriksson P, Archer T. DFrediksson A. 1990. Altered Behaviour in Adult Mice Exposed to a Single Low Dose of DDT and its Fatty Acide Conjungate as Neonates. Brain Res 514: 141-142.
    
    
35. Eriksson P, Nilsson-Hakansson L, Nordberg A, et al. 1990. Neonatal Exposure to DDT and its Fatty Acide Conjungate: Effects on Cholinergic and Behavorial Variables in the Adult Mouse. Neuro Toxicol 11: 345-354.
    

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