Interaction Profiles for Toxic Substances

For Everyone

Key points

  • Legislation (CERCLA) directs ATSDR to develop methods to determine health effects of substances commonly found together in the environment.
  • ATSDR developed a guidance manual that outlines methods for mixtures assessment and a series of Interaction Profiles.
  • Interaction Profiles succinctly characterize the toxicologic and adverse health effects information for mixtures of hazardous substances.
Digital composite of liquids and molecular structure by books on table

About the Interaction Profiles

The Interaction Profiles focus on priority mixtures of special concern, and assess health risks from exposure by evaluating data on the:

  • Toxicity of the whole priority mixture, and
  • Joint action of toxic chemicals in the mixture.

Interaction Profiles

Arsenic, Cadmium, Chromium, Lead
Interaction profile for arsenic, cadmium, chromium, and lead.
Arsenic, Hydrazines, Jet Fuels, Strontium-90, and Trichloroethylene
Toxic substances interactions of mixtures and health effects from exposure
Atrazine, Deethylatrazine, Diazinon, Nitrate, and Simazine
ATSDR's Interaction Profiles provide information on the health effects of combined chemicals, includ...
Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX)
Information on toxic substance combinations and health effects to protect the public health
Carbon Monoxide, Formaldehyde, Methylene Chloride, Nitrogen Dioxide, Tetrachloroethylene
Interaction profile for Carbon Monoxide, Formaldehyde, Methylene Chloride, Nitrogen Dioxide, Tetrach
Cesium, Cobalt, Polychlorinated Biphenyls, Strontium, and Trichloroethylene
Interaction profile for Cesium, Cobalt, Polychlorinated Biphenyls, Strontium, and Trichloroethylene.
Chlorinated Dibenzo-p-dioxins, Polybrominated Diphenyl Ethers, and Phthalates
Toxic substance mixture interaction and effect on health from exposure to Chlorinated Dibenzo-p-diox...
Chloroform, 1,1-Dichloroethylene, Trichloroethylene, and Vinyl Chloride
Interaction profile for Chloroform, 1,1-Dichloroethylene, Trichloroethylene, and Vinyl Chloride.
Chlorpyrifos, Lead, Mercury, and Methylmercury
The Interaction Profiles provide information about the health effects from specific combinations of...
Cyanide, Fluoride, Nitrate, and Uranium
Interaction profile for Cyanide, Fluoride, Nitrate, and Uranium.
Lead, Manganese, Zinc, and Copper
Interaction Profiles provide information on the health effects of the combination of specific chemic...
Mixtures of Insecticides: Pyrethroids, Organophosphorus Compounds, and Carbamates
Interaction profile for mixtures of insecticides: pyrethroids, and organophosphorus compounds
Persistent Chemicals Found in Breast Milk
Interaction profile for persistent chemicals found in breast milk.
Persistent Chemicals Found in Fish
Interaction profile for persistent chemicals found in fish.
Selected Metallic Ions in Wastewater from Unconventional Oil and Gas Extraction
Interaction profile: selected metallic ions in wastewater from unconventional oil and gas extraction
1,1,1-Trichloroethane, 1,1-Dichloroethane, Trichloroethylene, and Tetrachloroethylene
Interaction profile for 1,1,1-Trichloroethane, 1,1-Dichloroethane, Trichloroethylene, and Tetrachlor...

Resources

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Content Source
Agency for Toxic Substances and Disease Registry
About This Page
Published: November 12, 2024
Updated: November 12, 2024

This page was last updated on this date. Updates may include minor edits, image changes, or other modifications to page content.

Reviewed: August 26, 2026

The information on this page was last reviewed by subject matter experts to ensure accuracy.