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Chemical Mixtures Program

Program Assessment Objectives

  • Develop Interactions Profiles. Similar to the Agency toxicological profiles, these documents summarize the health effects caused by exposure to chemicals in a mixture.
  • Develop a Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures. A manual to assist health assessors in determining the impact of chemical mixture exposure on public health.
  • Develop Minimal Risk Level (MRLs) for chemical mixtures. Use existing methods to derive health guidance values for mixtures such as chlorinated dibenzodioxins (CDDs) and polybrominated biphenyls (PBBs).
  • Perform weight of evidence analyses for combinations of chemicals. These analyses are used to predict the influence of one chemical on the health effects of another chemical.
  •  Conduct collaborative studies with the National Institute of Environmental Health Sciences