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ATSDR's Substance-Specific Priority Data Needs

Filled PDNs [PDF - 92 KB]

ABCDE - FGHIJ - KLMNO - PQRST - UVWXYZ

Substances PDN Description Status(1)
Aldrin/Dieldrin
  • Dose-response data in animals for intermediate(2)-duration oral exposure
  • Bioavailability from soil
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Arsenic
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
  • Bioavailability from soil
Filled
Asbestos
  • Potential candidate for subregistry of exposed persons
  • Improved analytical methods for screening samples and determining the chemical structure of asbestos fibers.  Also, techniques to normalize studies in which different analytical methods were employed
Filled
Benzene
  • Epidemiologic studies on the health effects of benzene (special emphasis end points include immunotoxicity)
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled
Beryllium
  • Analytical methods to determine environmental speciation
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Cadmium
  • Analytical methods for biological tissues and fluids and environmental media
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Carbon tetrachloride
  • Immunotoxicology battery of tests via oral exposure
  • Half-life in soil
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled

Chlordane
 
  • Oral multigenerational studies to evaluate reproductive toxicity
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations potentially exposed to chlordane
  • Exposure levels in children
Filled
Chlorinated dibenzo-p-dioxins (CDDs)
  • Studies via oral exposure designed to assess childhood susceptibility
  • Exposure levels in humans (adults) living near hazardous waste sites
  • Exposure levels in children
Filled
Chloroform
  • Dose-response data in animals for intermediate-duration oral exposure
  • Epidemiologic studies on the health effects of chloroform (Special emphasis end points include cancer, neurotoxicity, reproductive and developmental toxicity, hepatotoxicity, and renal toxicity)
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled

Chromium
 
  • Dose-response data in animals for acute(3)-duration exposure to chromium (VI) via oral exposure
  • Dose-response data in animals for intermediate-duration exposure to chromium (VI) via oral exposure
  • Multigeneration reproductive toxicity study via oral exposure to chromium (VI)
  • Prenatal developmental toxicity study via oral exposure to chromium (VI)
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled

Cyanide
 
  • Evaluation of the environmental fate of cyanide in soil
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled
1,2-dibromo-3-chloropropane
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled
1,2-Dibromoethane
  • Immunotoxicity battery studies via oral exposure
  • Dose-response data in animals for acute-duration exposure by the oral route
Filled
1,2-Dichloroethane
  • Neurotoxicology battery of tests following inhalation exposure
  • Exposure levels in humans living near hazardous waste sites and other populations
Filled
1,1-Dichloroethene
  • Dose-response data in animals for acute-duration exposure by the inhalation route
  • Dose-response data in animals for chronic(4)-duration exposure by the inhalation route
  • Dose-response data in animals for acute-duration exposure by the oral route
  • Dose-response data in animals for intermediate-duration exposure by the oral route
  • Prenatal developmental toxicity studies following oral exposure
  • Exposure levels in humans living near hazardous waste sites and other populations
Filled
DDT
  • Epidemiologic studies on the health effects of DDT, DDD, and DDE (Special emphasis end points include immunotoxicity, and reproductive and developmental toxicity)
  • Bioavailability and bioaccumulation from soil
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled

Di(2-ethylhexyl) phthalate
 
  • Epidemiologic studies on the health effects of DEHP
  • Dose-response data in animals for acute-duration oral exposure
  • Dose-response data in animals for intermediate-duration oral exposure
  • Multigeneration reproductive toxicity study via oral exposure
  • Comparative toxicokinetic studies (Studies designed to examine how primates metabolize and distribute DEHP as compared with rodents via oral exposure)
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Di-n-butyl phthalate
  • Dose-response data in animals for acute- duration exposure via the oral route
  • In vivo genotoxicity studies
  • Environmental fate of di-n-butyl phthalate in environmental media
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Disulfoton
  • Immunotoxicology testing battery following oral exposure
Filled
Endosulfan (α,β, and sulfate)
  • Data on the bioavailability of endosulfan from soil
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Endrin/endrin aldehyde
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Ethylbenzene
  • Dose-response data for acute-duration exposure by the inhalation ­route
  • Dose-response data for chronic-duration exposure by the inhalation route
  • Dose-response data for intermediate-duration exposure by the oral ­route
  • Multigeneration toxicity study examining reproductive end points and indicators of endocrine disruption following inhalation exposure
  • Studies for comparative toxicokinetics
  • Exposure levels in humans living near hazardous waste sites
  • Exposure levels in children
Filled

 

Heptachlor/
heptachlor epoxide
  • Multigeneration reproductive toxicity studies via the oral route of exposure
  • Prenatal developmental toxicity studies via the oral route of exposure
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
  • Dose-response animal data for acute- and intermediate-duration oral exposures, including immunopathology
  • Bioavailability from contaminated air, water, and soil and bioaccumulation potential
Filled
Hexachloro-cyclohexane (α, β, γ, and δ)
  • Dose-response data for chronic-duration oral exposure
  • Mechanistic studies on the  neurotoxicity of hexachlorocyclohexane
  • Mechanistic studies on the hepatotoxicity of hexachlorocyclohexane
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Lead
  • Mechanistic studies on the neurotoxic effects of lead
  • Analytical methods for tissue levels
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Manganese
  • Dose-response data for acute- and intermediate-duration oral exposures
  • Toxicokinetic studies on animals to investigate uptake and absorption, relative uptake of differing manganese compounds, metabolism of manganese, and interaction of manganese with other substances following oral exposure
  • Epidemiological studies on the health effects of manganese (special emphasis end points include neurologic, reproductive, developmental, immunologic, and cancer)
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Mercury
  • Multigeneration reproductive toxicity study via oral exposure
  • Dose-response data in animals for chronic-duration oral exposure
  • Immunotoxicology studies via oral exposure
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Methoxychlor
  • Evaluate neurologic effects after long-term, low-level oral exposure
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations
  • Exposure levels in children
Filled
Methylene chloride
  • Dose-response data in animals for acute- and intermediate-duration oral exposure. The intermediate-duration study should include extended reproductive organ histopathology, neuropathology,  and immunopathology
  • Prenatal developmental toxicity study via the oral route
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled(5)
Nickel
  • Epidemiologic studies on the health effects of nickel (Special emphasis end points include reproductive toxicity)
  • Prenatal developmental toxicity study via the oral route
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled
Pentachlorophenol
  • Exposure levels in humans (adults) living near hazardous waste sites
  • Exposure levels in children through play activities near contaminated environmental media
Filled
Polychlorinated biphenyls (PCBs)
  • Epidemiologic studies on the health effects of PCBs (special emphasis end points include immunotoxicity, gastrointestinal toxicity, liver toxicity, kidney toxicity, thyroid toxicity, and reproductive/developmental toxicity)
  • Dose-response data in animals for acute-duration oral exposures
  • Dose-response data in animals for intermediate-duration oral exposures
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
  • Chronic toxicity and oncogenicity via oral exposure(6)
  • Aerobic PCB biodegradation in sediment(6)
  • PCB congener analysis(6)
Filled
Polycyclic aromatic hydrocarbons (PAHs)
(Includes 15 substances)
 
  • Dose-response data in animals for intermediate-duration oral exposures. The intermediate-duration study should include extended reproductive organ histopathology and immunopathology
  • Prenatal developmental toxicity study via inhalation or oral exposure
  • Mechanistic studies on PAHs, on how mixtures of PAHs can influence the ultimate activation of PAHs, and on how PAHs affect rapidly proliferating tissues
  • Dose-response data in animals for acute- and intermediate-duration inhalation exposures. The intermediate-duration study should include extended reproductive organ histopathology and immunopathology
  • Epidemiologic studies on the health effects of PAHs (Special emphasis end points include cancer, dermal, hemolymphatic,and hepatic toxicity)
  • Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
  • Exposure levels in children
Filled
Selenium
  • Epidemiologic studies on the health effects of selenium (special emphasis end points include cancer, reproductive and developmental toxicity, hepatotoxicity, and adverse skin effects)
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled
1,1,2,2-Tetrachloroethane
  • Exposure levels in humans living near hazardous waste sites and other populations
Filled
Tetrachloroethylene
  • Dose-response data in animals for acute-duration oral exposure, including neuropathology and demeanor, and immunopathology
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled
Toluene
  • Dose-response data in animals for acute- and intermediate-duration oral exposures. The intermediate-duration study should include an extended histopathologic evaluation of the immune system
  • Comparative toxicokinetic studies (characterization of absorption, distribution, and excretion via oral exposure)
  • Mechanism of toluene-induced neurotoxicity
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled
Toxaphene
  • Immunotoxicity studies for chronic-duration via oral route of exposure
Filled
Trichloroethylene
  • Dose-response data in animals for acute-duration oral exposure
  • Epidemiologic studies on the health effects of trichloroethylene (special emphasis end points include cancer, hepatotoxicity, renal toxicity, developmental toxicity, and neurotoxicity)
  • Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
Filled
Vinyl chloride
  • Dose-response data in animals for acute-duration inhalation exposure
  • Multigeneration reproductive toxicity study via inhalation
  • Prenatal developmental toxicity study via inhalation
Filled
Xylenes
  • Dose-response data for chronic-duration exposure by the oral route.  This study should be done in conjunction with the neurotoxicology battery of tests
  • Prenatal developmental toxicity study that includes neurodevelopmental end points following oral exposure
  • Exposure levels in humans living near hazardous waste sites and other populations
Filled

 

Zinc
  • Dose-response data in animals for acute- and intermediate-duration oral exposures. The intermediate-duration study should include an extended histopathologic evaluation of the immunologic and neurologic systems
  • Multigeneration reproductive toxicity study via oral exposure
Filled

(1) Filled: A priority data need is filled:

  • If it has been referred to one of the implementation mechanisms and research has been initiated, or
  • If an updated ATSDR toxicological profile contains relevant new studies, or if other relevant, peer-reviewed, and publicly available new studies (not included in the toxicological profile) have been identified since the finalization of the priority data needs document; and it is generally agreed that a priority data need no longer exists.

Furthermore, in the event a priority data need is considered filled, it does not necessarily mean that the study has been completed and that ATSDR has accepted the data. It does, however, indicate that the agency no longer considers it a priority to initiate additional studies at this time.

(2) Intermediate-duration exposure = 15 – 364 days.

(3) Acute-duration exposure = 14 days or less.

(4) Chronic-duration exposure = 365 days or more.

(5) Neurotoxicity testing remains a priority data need in the EPA/ATSDR test rule.

(6) Data need, not priority data need.

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