| Substances |
PDN Description |
Status(1) |
Aldrin/Dieldrin
|
Dose-response data in animals for intermediate(2)-duration oral
exposure
Bioavailability from soil
|
Filled |
Arsenic
|
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
| Asbestos |
Potential candidate for subregistry of exposed persons
|
Filled |
| Benzene |
Epidemiologic studies on the health effects of benzene (Special emphasis
end points include immunotoxicity)
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
| Beryllium |
Analytical methods to determine environmental speciation
Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
Exposure levels in children
|
Filled |
| Cadmium |
Analytical methods for biological tissues and fluids and environmental
media
Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
Exposure levels in children
|
Filled |
| Carbon tetrachloride |
Immunotoxicology battery of tests via oral exposure
Half-life in soil
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Chlordane
|
Oral multigenerational studies to evaluate reproductive toxicity
Exposure levels in humans (adults) living near hazardous waste sites and
other populations potentially exposed to chlordane
Exposure levels in children
|
Filled |
| Chlorinated dibenzo-p-dioxins (CDDs) |
Exposure levels in humans (adults) living near hazardous waste sites
Exposure levels in children
|
Filled |
| Chloroform |
Dose-response data in animals for intermediate-duration oral exposure
Epidemiologic studies on the health effects of chloroform (Special
emphasis end points include cancer, neurotoxicity, reproductive and
developmental toxicity, hepatotoxicity, and renal toxicity)
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Chromium
|
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers |
Filled |
Cyanide
|
Evaluation of the environmental fate of cyanide in soil
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
| 1,1-Dichloroethene |
Dose-response data in animals for acute(3)-duration exposure by the
inhalation route
Dose-response data in animals for chronic(4)-duration exposure by the
inhalation route
|
Filled |
| DDT |
Epidemiologic studies on the health effects of DDT, DDD, and DDE (Special
emphasis end points include immunotoxicity, and reproductive and
developmental toxicity)
Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
Exposure levels in children
|
Filled |
Di(2-ethylhexyl) phthalate
|
Comparative toxicokinetic studies (Studies designed to examine how
primates metabolize and distribute DEHP as compared with rodents via oral
exposure)
|
Filled |
| Di-n-butyl phthalate |
Dose-response data in animals for acute- duration exposure via the oral
route
In vivo genotoxicity studies
Environmental fate of di-n-butyl phthalate in environmental media
|
Filled |
Disulfoton
|
Immunotoxicology testing battery following oral exposure
|
Filled |
| Ethylbenzene |
Dose-response data for acute-duration exposure by the inhalation ¬route
Dose-response data for chronic-duration exposure by the inhalation route
Multigeneration toxicity study examining reproductive end points and
indicators of endocrine disruption following inhalation exposure
Studies for comparative toxicokinetics
Exposure levels in humans living near hazardous waste sites
Exposure levels in children
|
Filled |
Heptachlor/
heptachlor epoxide
|
Multigeneration reproductive toxicity studies via the oral route of
exposure
Prenatal developmental toxicity studies via the oral route of exposure
Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
Exposure levels in children
Dose-response animal data for acute- and intermediate-duration oral
exposures, including immunopathology
|
Filled |
| Hexachloro-cyclohexane (α, β, γ, and δ) |
Dose-response data for chronic-duration oral exposure
Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
Exposure levels in children |
Filled |
| Lead |
Mechanistic studies on the neurotoxic effects of lead
Analytical methods for tissue levels
Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
Exposure levels in children
|
Filled |
| Manganese |
Dose-response data for acute- and intermediate-duration oral exposures
(the intermediate-duration study should include reproductive histopathology
and an evaluation of immunologic parameters including manganese effects on
plaque-forming cells (SRBC), surface markers (D4:D8 ratio), and delayed
hypersensitivity reactions)
Toxicokinetic studies on animals to investigate uptake and absorption,
relative uptake of differing manganese compounds, metabolism of manganese,
and interaction of manganese with other substances following oral exposure
Epidemiological studies on the health effects of manganese (Special
emphasis end points include neurologic, reproductive, developmental,
immunologic, and cancer)
|
Filled |
| Mercury |
Multigeneration reproductive toxicity study via oral exposure
Dose-response data in animals for chronic-duration oral exposure
Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
Exposure levels in children
|
Filled |
Methoxychlor
|
Evaluate neurologic effects after long-term, low-level oral exposure
|
Filled |
| Methylene chloride |
Dose-response data in animals for acute- and intermediate-duration oral
exposure. The intermediate-duration study should include extended
reproductive organ histopathology, neuropathology, and immunopathology
Prenatal developmental toxicity study via the oral route
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled(5) |
| Nickel |
Epidemiologic studies on the health effects of nickel (Special emphasis
end points include reproductive toxicity)
Prenatal developmental toxicity study via the oral route
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
| Pentachlorophenol |
Exposure levels in humans (adults) living near hazardous waste sites
Exposure levels in children through play activities near contaminated
environmental media
|
Filled |
| Polychlorinated
biphenyls (PCBs) |
Epidemiologic studies on the health effects of PCBs (Special emphasis end
points include immunotoxicity, gastrointestinal toxicity, liver toxicity,
kidney toxicity, thyroid toxicity, and reproductive/developmental toxicity)
Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
Exposure levels in children
Chronic toxicity and oncogenicity via oral exposure(6)
Aerobic PCB biodegradation in sediment(6)
PCB congener analysis(6)
|
Filled |
Polycyclic aromatic hydrocarbons (PAHs)
(Includes 15 substances)
|
Dose-response data in animals for intermediate-duration oral exposures.
The intermediate-duration study should include extended reproductive organ
histopathology and immunopathology
Prenatal developmental toxicity study via inhalation or oral exposure
Mechanistic studies on PAHs, on how mixtures of PAHs can influence the
ultimate activation of PAHs, and on how PAHs affect rapidly proliferating
tissues
Dose-response data in animals for acute- and intermediate-duration
inhalation exposures. The intermediate-duration study should include
extended reproductive organ histopathology and immunopathology
Epidemiologic studies on the health effects of PAHs (Special emphasis end
points include cancer, dermal, hemolymphatic,and hepatic toxicity)
Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
Exposure levels in children
|
Filled |
| Selenium |
Epidemiologic studies on the health effects of selenium (Special emphasis
end points include cancer, reproductive and developmental toxicity,
hepatotoxicity, and adverse skin effects)
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
| Tetrachloroethylene |
Dose-response data in animals for acute-duration oral exposure, including
neuropathology and demeanor, and immunopathology
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
| Toluene |
Dose-response data in animals for acute- and intermediate-duration oral
exposures. The intermediate-duration study should include an extended
histopathologic evaluation of the immune system
Comparative toxicokinetic studies (Characterization of absorption,
distribution, and excretion via oral exposure)
Mechanism of toluene-induced neurotoxicity
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
| Trichloroethylene |
Dose-response data in animals for acute-duration oral exposure
Epidemiologic studies on the health effects of trichloroethylene (Special
emphasis end points include cancer, hepatotoxicity, renal toxicity,
developmental toxicity, and neurotoxicity)
Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
| Vinyl
chloride |
Dose-response data in animals for acute-duration inhalation exposure
Multigeneration reproductive toxicity study via inhalation
Prenatal developmental toxicity study via inhalation
|
Filled |
| Xylenes |
Dose-response data for chronic-duration exposure by the oral route. This
study should be done in conjunction with the neurotoxicology battery of
tests
Prenatal developmental toxicity study that includes neurodevelopmental end
points following oral exposure
Exposure levels in children
|
Filled |
| Zinc |
Dose-response data in animals for acute- and intermediate-duration oral
exposures. The intermediate-duration study should include an extended
histopathologic evaluation of the immunologic and neurologic systems
Multigeneration reproductive toxicity study via oral exposure
|
Filled |
Furthermore, in the event a priority data need is considered
filled, it does not necessarily mean that the study has been
completed and that ATSDR has accepted the data. It does, however,
indicate that the agency no longer considers it a priority to
initiate additional studies at this time.
Filled PDNs in PDF Format (file size 88k)
