| Substances |
PDN
Description |
Status
(1) |
Aldrin/Dieldrin
|
Exposure levels in humans living near hazardous waste sites
and other populations, such as exposed workers
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Arsenic |
Comparative toxicokinetic studies to determine if an
appropriate animal species can be identified
Half-lives in surface water, groundwater
Bioavailability from soil
|
Unfilled |
| Asbestos |
Epidemiologic studies of individuals occupationally exposed to
asbestos levels lower than those experienced before the
institution of current occupational standards governing the use
of asbestos, but higher than current levels in the general
population. These studies should be performed in conjunction
with the immunotoxicity studies
Immunotoxicity studies of individuals occupationally exposed
to asbestos
Development of human and rat lung retention models to aid in
extrapolating between rat and human data
Improved analytical methods for screening samples and
determining the chemical structure of asbestos fibers. Also,
techniques are needed to normalize studies in which different
analytical methods were employed
Exposure levels, fiber size distribution, and asbestos fiber
type in areas with natural geologic deposits of friable asbestos
and at hazardous waste sites. Also, techniques for estimating
air levels of asbestos from soil concentrations and activity
scenarios
Exposure levels in humans living near hazardous waste sites
and in other populations, such as humans living in areas with
naturally high levels of friable asbestos
|
Unfilled |
| Benzene |
Dose-response data in animals for acute(2)- and
intermediate(3)-duration oral exposure. The
intermediate-duration study should include an extended
reproductive organ histopathology
Prenatal developmental toxicity study via oral exposure
Neurotoxicology battery of tests via oral exposure
|
Unfilled
|
| Benzidine |
Dose-response data for acute(2)- and intermediate(3)-duration
exposure via the oral route (the study of intermediate-duration
exposure should include evaluation of reproductive and endocrine
organ histopathology, lymphoid tissues histopathology as well as
examination of relevant blood components, and nervous system
histopathology)
Exposure levels in humans living near hazardous waste sites
Exposure levels in children
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Beryllium |
Dose-response data in animals for acute- and
intermediate-duration inhalation exposures. The
intermediate-duration study should include extended reproductive
organ histopathology
Prenatal developmental toxicity study via inhalation exposure
Environmental fate in air; factors affecting bioavailability
in air
Immunotoxicology battery of tests following oral exposure
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Carbon tetrachloride |
Dose-response data in animals for chronic(4) oral
exposure. The study should include extended reproductive
organ and nervous tissue histopathology
Potential candidate for subregistry of exposed persons
|
Unfilled |
Chlordane
|
Bioavailability studies following ingestion of contaminated
media
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Chlorinated dibenzo-p-dioxins (CDDs) |
Studies via oral exposure designed to assess childhood
susceptibility
Comparative toxicokinetic studies examining the relative
absorption of CDDs across exposure routes and the relative
contribution of each exposure route to total body burdens
|
Unfilled |
Chloroethane
|
Potential candidate for subregistry of exposed persons
|
Unfilled |
Chloroform
|
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Chromium |
Dose-response data in animals for acute-duration exposure to
chromium (VI) and (III) via oral exposure and for
intermediate-duration exposure to chromium (VI) via oral
exposure
Multigeneration reproductive toxicity study via oral exposure
to chromium (III) and (VI)
Immunotoxicology battery of tests following oral exposure to
chromium (III) and (VI)
Prenatal developmental toxicity study via oral exposure to
chromium (III) and (VI)
|
Unfilled |
| Cyanide |
Potential candidate for subregistry of exposed persons
|
Unfilled |
1,2-dibromo-3-chloropropane
|
Dose-response data in animals for acute-duration exposure via
the oral route (including reproductive organ histopathology)
Dose-response data in animals for chronic-duration exposure
via the oral route (including reproductive organ histopathology)
Prenatal developmental toxicity study via oral exposure
Immunotoxicology testing battery via oral exposure
Neurotoxicology testing battery via oral exposure
Exposure levels in humans living near hazardous waste sites
and other exposed populations, such as exposed workers
Potential candidate for subregistry of exposed persons
|
Unfilled |
| 1,2-Dibromoethane |
Dose-response data in animals for acute- and
intermediate-duration exposure by the oral route (the study of
intermediate-duration exposure should include evaluation of
neuropathology and observation for overt signs of neurotoxicity)
Multigeneration reproductive toxicity studies via oral
exposure
Prenatal toxicity studies via oral exposure
Immunotoxicity battery studies via oral exposure
Exposure levels in humans living near hazardous waste sites
and in other populations, such as workers exposed to
1,2-dibromoethane
Exposure levels in children
Potential candidate for subregistry of exposed persons
|
Unfilled |
1,2-Dichloroethane
|
Dose-response data in animals for acute-duration (14-day)
exposure by the inhalation route, including a comparison of
young and adult animals
Dose-response data in animals for acute-duration (14-day)
exposure by the oral route, including a comparison of young and
adult animals
Dose-response data in animals for intermediate-duration
exposure by the inhalation route (the study should be performed
in conjunction with the neurotoxicology battery of tests)
Neurotoxicology battery of tests following inhalation exposure
Neurotoxicology battery of tests following oral exposure
Dose-response data in animals for chronic-duration exposure by
the oral route
Prenatal developmental toxicity data for inhalation exposure
(assessment of developmental cardiotoxicity and neurotoxicity)
Prenatal developmental toxicity data for oral exposure
(assessment of developmental cardiotoxicity and neurotoxicity)
Additional analyses and studies for comparative toxicokinetics
across species, ages, routes, and durations
Childrens susceptibility
Exposure levels in humans living near hazardous waste sites
Exposure levels in children
Potential candidate for subregistry of exposed persons
|
Unfilled |
| 1,1-Dichloroethene |
Dose-response data in animals for acute- and
intermediate-duration exposure by the oral route
Carcinogenicity studies in two species following inhalation
exposure
Reproductive toxicity studies assessing male and female end
points following inhalation exposure
Prenatal developmental toxicity studies following oral
exposure
Immunotoxicology battery of tests following oral exposure
Battery of neurobehavioral tests following inhalation exposure
Childrens susceptibility
Exposure levels in humans living near hazardous waste sites
Exposure levels in children
Potential candidate for subregistry of exposed persons
|
Unfilled |
| DDT |
Dose-response data in animals for chronic-duration oral
exposure
Comparative toxicokinetic study (across routes/species)
Bioavailability and bioaccumulation from soil
Potential candidate for subregistry of exposed persons
|
Unfilled |
Di(2-ethylhexyl) phthalate
|
Epidemiologic studies on the health effects of DEHP (Special
emphasis end points include cancer)
Dose-response data in animals for acute- and
intermediate-duration oral exposures. The intermediate-duration
study should include an extended histopathologic evaluation of
the immunologic and neurologic systems
Multigeneration reproductive toxicity study via oral exposure
Exposure levels in humans living near hazardous waste sites
and other populations, such as exposed workers
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Di-n-butyl phthalate |
Dose-response data in animals for chronic-duration exposure
via the oral route
Carcinogenicity studies via oral exposure
Exposure levels in humans living near hazardous waste sites
and other populations, such as exposed workers
Bioavailability in contaminated environmental media near
hazardous waste sites
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Disulfoton |
Exposure levels of disulfoton in tissues/fluids for
populations living near hazardous waste sites and other
populations, such as exposed workers
Disulfoton should be considered as a potential candidate for a
subregistry of exposed persons
|
Unfilled |
| Endosulfan (α,β, and sulfate) |
Acute-duration oral exposure studies
Data on sensitive neurologic end point following oral exposure
Exposure levels in humans living near hazardous waste sites
and other populations, such as exposed workers
Data on the bioavailability of endosulfan from soil
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Endrin/endrin aldehyde |
Dose-response animal data for acute oral exposure to endrin
Multigeneration reproductive toxicity studies via oral
exposure to endrin
Accurately describe the toxicokinetics of endrin and its
degradation products and identify the animal species to be used
as the most appropriate model for human exposure
Exposure levels for endrin and its degradation products in
humans living near hazardous waste sites
Accurately describe the environmental fate of endrin,
including environmental breakdown products and rates, media
half-lives, and chemical and physical properties of the
breakdown products that help predict mobility and volatility
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Ethylbenzene |
Dose-response data for acute- and intermediate-duration
exposure by the oral ¬route; the study of intermediate-duration
exposure should include an evaluation of clinical signs of
neurotoxicity and histopathology of reproductive organs,
endocrine glands, and nervous system
Prenatal developmental study with continued assessment of
offspring during postnatal development following oral exposure
Potential candidate for subregistry of exposed persons
|
Unfilled |
Heptachlor/
heptachlor epoxide
|
Bioavailability from contaminated air, water, and soil and
bioaccumulation potential
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Hexachlorobutadiene |
Dose-response data in animals for acute-duration exposure via
the oral route
Exposure levels in humans living near hazardous waste sites
and other populations, such as exposed workers
Environmental fate studies that determine the extent to which
hexachlorobutadiene volatilizes from soil, and studies that
determine the reactions and rates which drive degradation in
soil
Bioavailability studies in soil and plants
Potential candidate for subregistry of exposed persons
|
Unfilled |
Hexachlorocyclohexane (α, β, γ, and δ)
|
Mechanistic studies on the neurotoxicity, hepatotoxicity,
reproductive toxicity, and immunotoxicity of
Hexachlorocyclohexane
Potential candidate for subregistry of exposed persons
|
Unfilled |
Manganese
|
Exposure levels in humans living near hazardous waste sites
and other populations, such as exposed workers
Relative bioavailability of different manganese compounds and
bioavailability of manganese from soil
|
Unfilled |
Mercury
|
Immunotoxicology battery of tests via oral exposure
Potential candidate for subregistry of exposed persons
|
Unfilled |
Methoxychlor
|
Exposure levels of methoxychlor and primary metabolites in
humans living near hazardous waste sites and in those
individuals with the potential to ingest it
Evaluate the fate, transport, and levels of the degradation
products of methoxychlor in soil
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Methylene chloride |
Potential candidate for subregistry of exposed persons
|
Unfilled |
Nickel
|
Dose-response data in animals for acute- and
intermediate-duration oral exposures
Neurotoxicology battery of tests via oral exposure
Bioavailability of nickel from soil
Potential candidate for subregistry of exposed persons
|
Unfilled |
Pentachlorophenol
|
Comparative toxicokinetic studies
Potential candidate for subregistry of exposed persons
|
Unfilled |
Polychlorinated biphenyls (PCBs)
|
Dose-response data in animals for acute- and
intermediate-duration oral exposures
Biodegradation of PCBs in water; bioavailability of PCBs in
air, water, and soil
Dose-response data in animals for acute- and
intermediate-duration inhalation exposures. The
intermediate-duration study should include extended reproductive
organ histopathology
Potential candidate for subregistry of exposed persons
|
Unfilled |
Polycyclic aromatic hydrocarbons (PAHs)
(Includes 15 substances)
|
Potential candidate for subregistry of exposed persons
|
Unfilled |
Selenium
|
Dose-response data in animals for acute-duration oral exposure
Immunotoxicology battery of tests via oral exposure
Potential candidate for subregistry of exposed persons
|
Unfilled |
1,1,2,2-Tetrachloroethane
|
Prenatal developmental toxicity study by the oral route
Immunotoxicity battery following oral exposure
Mammalian in vivo genotoxicity assays
Exposure levels in humans living near hazardous waste sites
Exposure levels in children
Potential candidate for subregistry of exposed persons
|
Unfilled |
Tetrachloroethylene
|
Potential candidate for subregistry of exposed persons
|
Unfilled |
Toluene
|
Potential candidate for subregistry of exposed persons
Neurotoxicology battery of tests via oral exposure
|
Unfilled |
Toxaphene
|
Identify the long-term health consequences of exposure to
environmental toxaphene via oral exposure
Conduct additional immunotoxicity studies for chronic-duration
via oral route of exposure
Conduct additional neurotoxicity studies for chronic-duration
via oral route of exposure
Exposure levels in humans living in areas near hazardous waste
sites with toxaphene and in those individuals with the potential
to ingest it
Potential candidate for subregistry of exposed persons
|
Unfilled |
Vinyl chloride
|
Dose-response data in animals for chronic-duration inhalation
exposure
Mitigation of vinyl chloride-induced toxicity
Exposure levels in humans living near hazardous waste sites
and other populations, such as exposed workers
Potential candidate for subregistry of exposed persons
|
Unfilled |
| Xylenes |
Neurotoxicology battery of tests following oral exposure
Two-generation reproductive study following oral exposure
Exposure levels in humans living near hazardous waste sites
Potential candidate for subregistry of exposed persons
|
Unfilled |
Zinc
|
Carcinogenicity testing (2-year bioassay) via oral exposure
Exposure levels in humans living near hazardous waste sites
and other populations, such as exposed workers
Potential candidate for subregistry of exposed persons
|
Unfilled |
Unfilled PDNs
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