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Public Health Statement for Bromomethane

(Bromometano)

September 1992

CAS#: 74-83-9

Public Health Statement PDF PDF Version, 57 KB


This Public Health Statement is the summary chapter from the Toxicological Profile for bromomethane. It is one in a series of Public Health Statements about hazardous substances and their health effects. A shorter version, the ToxFAQs™, is also available. This information is important because this substance may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. For more information, call the ATSDR Information Center at 1-888-422-8737.


This Statement was prepared to give you information about bromomethane and to emphasize the human health effects that may result from exposure to it. The Environmental Protection Agency (EPA) has identified 1,177 sites on its National Priorities List (NPL). Bromomethane has been found in at least 12 of these sites. However, we do not know how many of the 1,177 NPL sites have been evaluated for bromomethane. As EPA evaluates more sites, the number of sites at which bromomethane is found may change. This information is important for you to know because bromomethane may cause harmful health effects and because these sites are potential or actual sources of human exposure to bromomethane.

When a chemical is released from a large area, such as an industrial plant, or from a container, such as a drum or bottle, it enters the environment as a chemical emission. This emission, which is also called a release, does not always lead to exposure. You can be exposed to a chemical only when you come into contact with the chemical. You may be exposed to it in the environment by breathing, eating, or drinking substances containing the chemical or from skin contact with it.

If you are exposed to a hazardous chemical such as bromomethane, several factors will determine whether harmful health effects will occur and what the type and severity of those health effects will be. These factors include the dose (how much), the duration (how long), the route or pathway by which you are exposed (breathing, eating, drinking, or skin contact), the other chemicals to which you are exposed, and your individual characteristics such as age, sex, nutritional status, family traits, life style, and state of health.

1.1 What is 1,2-dibromo-3-chloropropane?

Bromomethane (also called methyl bromide) is a colorless gas without much smell. Some bromomethane is formed in the ocean, probably by algae or kelp. However, most is made by humans to kill various pests (rats, insects, fungus, etc.) that might be present in homes, foods, or soil. Some bromomethane is also used to make other chemicals.

Bromomethane is usually stored in sealed containers to keep it from evaporating. If leaking containers of bromomethane are put in a waste site, most of the bromomethane will probably escape into the air. Small amounts might leak into the soil or pass through the soil and dissolve in underground water. Bromomethane has been found in underground water at two hazardous waste sites on the NPL.

Bromomethane breaks down in the environment to other chemicals. In air, it usually takes about 11 months for half the bromomethane that was released to disappear. In underground water, it usually takes about 1 month for half the bromomethane to break down.


1.2 How might I be exposed to 1,2-dibromo-3-chloropropane?

Because bromomethane is a gas, you are most likely to be exposed by breathing it in air. In most places around the world, levels in air are usually less than 0.025 parts of bromomethane per billion parts of air (ppb). Some cities have higher levels (up to about 1–2 ppb) because of releases from chemical factories and automobile exhausts. You will probably not be exposed to high levels unless you are near a place where bromomethane is being used for fumigation. Workers who fumigate homes or fields may be exposed to very high levels if proper safety precautions are not followed. Because bromomethane evaporates so quickly, it is usually not found in food, surface water, or soil.


1.3 How can 1,2-dibromo-3-chloropropane enter and leave my body?

If bromomethane is present at a waste site, you are most likely to be exposed to it by breathing the vapors in contaminated air. You might also be exposed by drinking water from contaminated wells, although this is less likely. If you breathe in bromomethane, about half of it will pass through your lungs and enter your blood. Studies in animals suggest that if you swallow bromomethane in water, nearly all of it will pass through your stomach or intestines and enter your body. Bromomethane that enters your body either from your lungs or stomach is quickly spread throughout your body by your blood. Most bromomethane in your body is broken down into other chemicals, and these chemicals leave your body in the urine or in the air you breathe out. This usually begins happening within minutes, and is usually nearly complete within several days. We do not know how much bromomethane can enter your body through the skin, but the amount is probably small.


1.4 How can 1,2-dibromo-3-chloropropane affect my health?

If you breathe bromomethane, you may develop a headache and begin to feel weak and nauseated several hours later. If you breathe a large amount, fluid may build up in your lungs and it may be hard to breathe. You may have muscle tremors, and sometimes even seizures. Your kidneys may also be injured, and urine production may slow or stop. In severe cases, these effects can lead to death. In less serious cases, most of these effects usually disappear after several weeks, but some of the effects may never go away.

Studies in animals suggest that if you swallow bromomethane, you might experience stomach irritation but would probably not experience lung, kidney, or brain injury. Bromomethane that gets on your skin can cause itching, redness, and blisters.

Studies in animals also suggest that bromomethane does not cause birth defects and does not interfere with normal reproduction except at high exposure levels. Animals that breathed bromomethane for 2 years did not develop cancer. Animals that swallowed bromomethane for 25 weeks had changes in their stomachs that could have been an early sign of cancer, but we do not know if swallowing bromomethane for a longer time would cause cancer. Both the International Agency for Research on Cancer and the EPA have determined that bromomethane is not classifiable as to its carcinogenicity in humans.


1.5 Is there a medical test to determine whether I have been exposed to 1,2-dibromo-3-chloropropane?

Several tests are available to tell whether you have been exposed to bromomethane, but each has limitations. The most direct test measures bromomethane in your blood or in the air you breathe out. However, this test is not usually used because most bromomethane does not stay in the body very long (see Section 1.3) and special measuring equipment is needed. More often, the main breakdown product of bromomethane (bromide) is measured in blood samples. Bromide is normally present in the blood of all people, but the levels of bromide increase when people are exposed to bromomethane. The amount of increase depends on the level of exposure. Tests for bromide are only useful if done within 1-2 days following exposure, and are not very helpful in predicting if exposed persons will have health effects or how serious the effects will be, because not all people respond to bromomethane the same way.


1.6 What recommendations has the federal government made to protect human health?

Concentrated bromomethane can be very dangerous, so the EPA allows only licensed professional fumigators to buy or use bromomethane. The government does not have any regulations at present about how much bromomethane can be present in outdoor air or water, but EPA requires water companies to test for this chemical in their water. The Food and Drug Administration (FDA) has set limits of 125–400 parts of bromide per million parts of food (ppm) for how much bromide may remain in food after the food is treated with bromomethane. The Occupational Safety and Health Agency (OSHA) limits the average level of bromomethane in workplace air to 5 ppm, and recommends that exposures be reduced to the lowest level feasible.


References

Agency for Toxic Substances and Disease Registry (ATSDR). 1992. Toxicological profile for bromomethane. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.


Where can I get more information?

If you have questions or concerns, please contact your community or state health or environmental quality department or:

For more information, contact:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
1600 Clifton Road NE, Mailstop F-57
Atlanta, GA 30333
Phone: 1-800-CDC-INFO · 888-232-6348 (TTY)
Fax: 1-770-488-4178
Email: Contact CDC-INFO

ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.

Information line and technical assistance:
Phone: 888-422-8737
FAX: (770)-488-4178

To order toxicological profiles, contact:
National Technical Information Service
5285 Port Royal Road
Springfield, VA 22161
Phone: 800-553-6847 or 703-605-6000

Disclaimer
Some PDF files may be electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the toxicological profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the toxicological profile home page, which also contains other important information about the profiles.

The information contained here was correct at the time of publication. Please check with the appropriate agency for any changes to the regulations or guidelines cited.

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