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Because the properties sampled were residential, it is anticipated that populations potentially exposed to contamination will include children and adults.

PCBs can be absorbed into the body via ingestion, inhalation, or dermal exposure following ingestion of dust or soil, inhalation of PCB-laden dust, or direct dermal contact with PCBs in soil or dust. In humans, long-term exposure to PCBs can affect the skin and liver; reproductive, endocrine, immunosuppressive, and carcinogenic effects have been observed in animal studies [6]. PCBs have very low potential for producing acute toxic effects [6].

An immunosuppressant effect was observed in a study of monkeys chronically exposed to 0.005 mg/kg/day of PCBs. On the basis of this study of monkeys, ATSDR has derived a chronic oral Minimal Risk Level (MRL) for PCBs of 2.0E-05 mg/kg/day. An MRL is defined as an estimate of daily human exposure to a dose of a chemical that is likely to be without an appreciable risk of adverse noncancerous effects over a specified duration of exposure [6]. Screening level exposure-dose calculations indicate that children in some houses may exceed the MRL.

Since screening analysis identified potential for health concern, soil and dust PCBs concentrations were evaluated using averaged daily doses estimated for both child and adult residential exposure scenarios and both cancer and non-cancer dose response relationships for PCBs. The exposure dose equation and parameter assumptions used for soil assessment followed that found in EPA RAGS. Exposure equations used for indoor dust assessment were based on ongoing methods development by a combined ATSDR/EPA/CDC workgroup on residential dust pathway analysis. Evaluations of health concerns were made on a house-by-house basis using estimated excess individual cancer risk, a margin of exposure analysis relative to the identified LOAEL for immunosuppression, and qualitative consideration of uncertainty based on site specific data.

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