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PFAS Health Effects

The health effects of PFOS, PFOA, PFHxS, and PFNA have been more widely studied than other per- and polyfluoroalkyl substances (PFAS). Some, but not all, studies in humans with PFAS exposure have shown that certain PFAS may:

  • affect growth, learning, and behavior of infants and older children
  • lower a woman’s chance of getting pregnant
  • interfere with the body’s natural hormones
  • increase cholesterol levels
  • affect the immune system
  • increase the risk of cancer

Scientists are still learning about the health effects of exposures to mixtures of PFAS.

For the most part, laboratory animals exposed to high doses of one or more of these PFAS have shown changes in liver, thyroid, and pancreatic function, as well as some changes in hormone levels. Because animals and humans process these chemicals differently, more research will help scientists fully understand how PFAS affect human health.

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