Toxicological Profile for Endrin

Title: Toxicological Profile for Endrin

Subject of Planned Report: The ATSDR toxicological profile succinctly reviews the toxicologic, epidemiologic, and adverse health effects for the substance being described.  It also summarizes environmental fate and transport mechanisms and the potential for human exposure.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment June 2019

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: Toxicology, Epidemiology, Environmental Fate & Transport, Environmental Health

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. Jonathan Doorn
1. Jonathan Doorn
Academic and Professional Credentials PhD (Toxicology University of Michigan) 2001
Postdoctoral Fellowship (Pharmacology/Pharmaceutical Sciences University of Colorado) 2004
Current Position Title Associate Professor of Medicinal and Natural Products Chemistry (with tenure)
Division Chair of Medicinal and Natural Products Chemistry
Co-Director, Oxidative Stress and Metabolism Core
Environmental Health Sciences Research Center
January 2016 – Present
Organizational Affiliation(s) The University of Iowa
College of Pharmacy,
Division of Medicinal and Natural Products Chemistry
Iowa City, IA 52242
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: Toxicology; Neurotoxicology; Toxic neurotransmitter metabolites in aged and diabetic human myocardium;
Experience:Pesticide-Mediated Generation of a Toxic Neurotransmitter Metabolite; Contribution of Glial Cells to Neurotoxicity and Neurodegeneration; Dr. Doorn’s work involves examining the role of reactive intermediates in toxicity and disease. Specifically, his mechanistic, hypothesis-driven research focuses on the potential role of protein modification by a reactive metabolite of dopamine metabolism in neurotoxicity and neurodegenerative disease, i.e. Parkinson’s disease. Dopamine (DA) is an important neurotransmitter that is metabolized by monoamine oxidase to 3,4-dihydroxyphenylacetaldehyde (DOPAL), an intermediate shown to be reactive toward proteins and toxic to dopaminergic cells.
Recommended by Scientific/Professional Society or General Public No
2. J. E. Klaunig
2. J. E. Klaunig
Academic and Professional Credentials Ph.D.
Fellow, Academy of Toxicological Sciences
Fellow, International Academy of Toxicological Pathology
Current Position Title Professor, Environmental Health
Professor, School of Public and Environmental Affairs
Laboratory of Investigative Toxicology and Pathology
Organizational Affiliation(s) Indiana University
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: Pathology, Toxicology, Carcinogenesis, environmental health
Experience: 2008 – present Editorial Board, Toxicology , 2005 – 2008  Editor- in-Chief, Toxicologic Patholog. Publications:
Recommended by Scientific/Professional Society or General Public No
3. Debasis Bagchi
3. Debasis Bagchi
Academic and Professional Credentials PhD (Medicinal Chemistry, Indian Institute of Chemical Biology, Calcutta, 1982)
Current Position Title Chief Scientific Officer; Cepham Research Center
San Francisco Bay Area
Industry Pharmaceuticals Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX
Organizational Affiliation(s) Cepham Research Center;
University of Houston College of Pharmacy
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline:Medicinal chemistry, pharmacology, metabolism (energy); effects of natural products on metabolism; nutraceutical and functional foods
Experience:Immediate Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL.
Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. Dr. Bagchi is one of the Associate Editors of the Journal of Functional Foods, Journal of the American College of Nutrition, and Archives of Medical and Biomedical Research, and also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, The Original Internist, and others.
Recommended by Scientific/Professional Society or General Public No

Charge to Peer Reviewers

Peer Reviewers’ Comments and CDC/ATSDR’s Response to Reviewers’ Comments: Disposition of Peer Review Comments for Toxicological Profile for Endrin [PDF – 282 KB]

 The ISI/HISA Dissemination Itself:

Page last reviewed: July 18, 2019