Toxicological Profile for Endrin
Title: Toxicological Profile for Endrin
Subject of Planned Report: The ATSDR toxicological profile succinctly reviews the toxicologic, epidemiologic, and adverse health effects for the substance being described. It also summarizes environmental fate and transport mechanisms and the potential for human exposure.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.
Type of Dissemination: ISI
Timing of Review (including deferrals): 2018
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment June 2019
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 3
Primary Disciplines or Expertise: Toxicology, Epidemiology, Environmental Fate & Transport, Environmental Health
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
| Academic and Professional Credentials | PhD (Toxicology University of Michigan) 2001 Postdoctoral Fellowship (Pharmacology/Pharmaceutical Sciences University of Colorado) 2004 |
|---|---|
| Current Position Title | Associate Professor of Medicinal and Natural Products Chemistry (with tenure) Division Chair of Medicinal and Natural Products Chemistry Co-Director, Oxidative Stress and Metabolism Core Environmental Health Sciences Research Center January 2016 – Present |
| Organizational Affiliation(s) | The University of Iowa College of Pharmacy, Division of Medicinal and Natural Products Chemistry Iowa City, IA 52242 |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: Toxicology; Neurotoxicology; Toxic neurotransmitter metabolites in aged and diabetic human myocardium; Experience:Pesticide-Mediated Generation of a Toxic Neurotransmitter Metabolite; Contribution of Glial Cells to Neurotoxicity and Neurodegeneration; Dr. Doorn’s work involves examining the role of reactive intermediates in toxicity and disease. Specifically, his mechanistic, hypothesis-driven research focuses on the potential role of protein modification by a reactive metabolite of dopamine metabolism in neurotoxicity and neurodegenerative disease, i.e. Parkinson’s disease. Dopamine (DA) is an important neurotransmitter that is metabolized by monoamine oxidase to 3,4-dihydroxyphenylacetaldehyde (DOPAL), an intermediate shown to be reactive toward proteins and toxic to dopaminergic cells. https://www.ncbi.nlm.nih.gov/pubmed?term=Doorn%2C%20Jonathan%20A%5BFull%20Author%20Name%5D&cmd=DetailsSearch |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | Ph.D. Fellow, Academy of Toxicological Sciences Fellow, International Academy of Toxicological Pathology |
|---|---|
| Current Position Title | Professor, Environmental Health Professor, School of Public and Environmental Affairs Laboratory of Investigative Toxicology and Pathology |
| Organizational Affiliation(s) | Indiana University |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: Pathology, Toxicology, Carcinogenesis, environmental health Experience: 2008 – present Editorial Board, Toxicology , 2005 – 2008 Editor- in-Chief, Toxicologic Patholog. Publications: https://www.ncbi.nlm.nih.gov/pubmed?term=Klaunig%2C%20James%20E%5BFull%20Author%20Name%5D&cmd=DetailsSearch |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD (Medicinal Chemistry, Indian Institute of Chemical Biology, Calcutta, 1982) MACN, CNS, MAIChE |
|---|---|
| Current Position Title | Chief Scientific Officer; Cepham Research Center San Francisco Bay Area Industry Pharmaceuticals Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX |
| Organizational Affiliation(s) | Cepham Research Center; University of Houston College of Pharmacy |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline:Medicinal chemistry, pharmacology, metabolism (energy); effects of natural products on metabolism; nutraceutical and functional foods Experience:Immediate Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. Dr. Bagchi is one of the Associate Editors of the Journal of Functional Foods, Journal of the American College of Nutrition, and Archives of Medical and Biomedical Research, and also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, The Original Internist, and others. https://www.ncbi.nlm.nih.gov/pubmed?term=Bagchi%2C%20Debasis%5BFull%20Author%20Name%5D&cmd=DetailsSearch |
| Recommended by Scientific/Professional Society or General Public | No |
Peer Reviewers’ Comments and CDC/ATSDR’s Response to Reviewers’ Comments: Disposition of Peer Review Comments for Toxicological Profile for Endrin [PDF – 282 KB]
The ISI/HISA Dissemination Itself:
https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=617&tid=114