Toxicological Profile for Ethylene Glycol

Title: Toxicological Profile for Ethylene Glycol

Subject of planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): April 2010

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile was made available for a 90-day public comment period on October 23, 2007.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3 or fewer

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Charge to Peer Reviewers: DTEM Charge to Peer Reviewers

Peer Reviewers

1. Phillip Goad
1. Phillip Goad
Academic and Professional Credentials B.S., Magna Cum Laude, Chemistry, Harding College
Ph.D., Interdisciplinary Toxicology, University of Arkansas for Medical Sciences
Current Position Title Partner and Senior Toxicologist, Center for Toxicology and Environmental Health, Little Rock, AR
Organizational Affiliation(s) Current member, Society of Toxicology
Teratology Society
American Industrial Hygiene Association
Past member, Middle Atlantic Reproduction and Teratology
Areas of Expertise, Discipline, Relevant Experiences Dr. Goad is a renowned expert in the biochemistry of alcohol, ethanol, methanol, and other hydrocarbons, and has performed specific research into the teratogenicity and developmental toxicity of ethylene glycol. He has authored and coauthored over 35 presentations, abstracts, and symposia proceedings contributions as well as over 20 original research articles in peer-reviewed scientific journals.
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2. Jerrol Leiken
2. Jerrol Leiken
Academic and Professional Credentials B.S. (with honors), General Science, University of Iowa
M.D., The Chicago Medical School
Current Position Title Lecturer, Department of Medicine, College of Medicine, University of Illinois at Chicago, 1995-present
Professor of Medicine, Rush Medical College, 1998-present
Professor, Department of Pharmacology, Rush Medical College, 2000-present
Professor, Department of Pharmacology, Rush Medical College, 2000-present
Professor, Health System Management, Rush Medical College (complemental status), 2001-present
ENH OMEGA, Director of Medical Toxicology
Glenbrook and Highland Park Hospitals, 2001-present
Attending Physician, Children’s Memorial Hospital, 2002-present
Organizational Affiliation(s) Diplomate, National Board of Medical Examiners, 7/81
American Board of Internal Medicine, 9/84
American Board of Emergency Medicine, 10/85
American Board of Medical Toxicology, 10/88
American Association of Medical Review Officers, 6/92
American Board of Quality Assurance and Utilization Review Physicians, 1992
Areas of Expertise, Discipline, Relevant Experiences Dr. Leiken is among the foremost and experienced medical toxicologists in the United States. He has authored and coauthored over 150 peer reviewed journal articles on medical toxicology and other topics, including several articles on the detection and toxicology of ethylene glycol. He has authored and coauthored over 35 chapters to medical texts and other scientific books; and he has made numerous presentations to professional medical and scientific societies, including the co-presentation of four separate presentations at the 2006 North American Congress of Clinical Toxicology. He has peer reviewed articles for numerous professional journals, including the American Journal of Emergency Medicine, Annals of Internal Medicine, Annals of Pharmacotherapy, Archives of Internal Medicine, Critical Care Medicine, Journal of the American Medical Association, Journal of General Internal Medicine, Journal of Occupational and Environmental Medicine, Journal of Pharmacy Technology, Journal of Toxicology – Clinical Toxicology, Medical Update for Psychiatrists, Journal of Occupational & Environmental Medicine Reviewer’s Commentary (2002), and the Quarterly Journal of Medicine (2003).
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3. Kenneth McMartin
3. Kenneth McMartin
Academic and Professional Credentials B.A., Chemistry, Coe College
Ph.D., Pharmacology, University of Iowa, Iowa City
Current Position Title Professor, Department of Pharmacology and Therapeutics, Section of Toxicology, Louisiana State University Medical Center, Shreveport, LA
Organizational Affiliation(s) Current member: Society of Toxicology, American Association for the Advancement of Science, Research Society on Alcoholism, International Society for Biomedical Research on Alcoholism, American Society for Pharmacology and Experimental Therapeutics, American Academy of Clinical Toxicology, American Society for Nutrition, Society for In Vitro Biology (1994-2002)
Areas of Expertise, Discipline, Relevant Experiences Professor McMartin is an internationally recognized expert in the toxicology of alcohol and ethylene glycol. He has authored numerous papers and made presentations on the toxicology of ethylene glycol at professional gatherings, including a seminar on the mechanism of acute ethylene glycol toxicity in humans at the meeting of the North American Chemistry Council (Rosslyn, VA 2001). He has authored and co-authored over 77 peer reviewed articles in professional journals, 28 books, book chapters, and published letters, and over 128 abstracts, many of them on issues relating to the toxicology and metabolism of ethylene glycol in humans and animal models. In his laboratory at LSU, his current research is focused on how calcium oxalate, an ethylene glycol metabolite, damages the kidney and vascular endothelium. His investigation is focused on the mechanisms of cell death in kidney and endothelial cells in culture, in particular, the effects of oxalate on mitochondrial function. The research has as its goal the design of treatments that can block the development of toxicity from oxalate and be useful in treating ethylene glycol poisoning.
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Page last reviewed: August 18, 2015