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Toxicological Profile for 2,4-Diphenoxyacetic Acid

Title: Toxicological Profile for 2,4-Diphenoxyacetic Acid

Subject of planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): November 2016

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment in 2017

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. Blair, Aaron E

Academic and Professional Credentials PhD, MPH
Current Position Title Scientist Emeritus
Organizational Affiliation(s) Division of Cancer
Epidemiology and Genetics
National Cancer Institute, Rockville, Maryland
Areas of Expertise, Discipline, Relevant Experiences Evaluating cancer and other disease risks associated with agricultural exposures (pesticides), chemicals in the workplace and the general environment, physical activity and disease, methodologic issues in occupational epidemiology, and studies of under-investigated populations. He has received the NIH Director’s Award, the PHS Special Recognition Award, NIH Merit Award, the DHHS Quality of Work Life Award, the University of North Carolina H.A. Tyroler Distinguished Alumni Award, the John Goldsmith Award for Outstanding Contributions to Environmental Epidemiology from the International Society for Environmental Epidemiology, and The Harriet Barr Distinguished Alumnus Award from the Public Health Alumnus Association of the University of North Carolina and the NIH Director’s Award for the Deepwater Horizon Gulf Oil Spill Study. He has served on numerous review groups for IARC, EPA, and other agencies and organizations. Dr. Blair has authored more than 450 publications on occupational and environmental causes of cancer.
Recommended by Scientific/Professional Society or General Public No

2. Wilson, Nancy K

Academic and Professional Credentials  


Current Position Title Consultant
Organizational Affiliation(s) Wilson Associates
Chapel Hill, NC
Areas of Expertise, Discipline, Relevant Experiences Years of experience in evaluating pesticides exposures in children; analysis of organophosphate and pyrethroid pesticides; biomonitoring and evaluation of children’s exposures to chlorpyrifos, diazinon, pentachlorophenol, and 2,4-dichlorophenoxyacetic acid.
Recommended by Scientific/Professional Society or General Public No

3. Costa, Lucio G.

Academic and Professional Credentials PhD, PharmD
Current Position Title Professor
Organizational Affiliation(s) Department of Environmental and Occupational
Health Sciences
University of Washington
Seattle, Washington
Areas of Expertise, Discipline, Relevant Experiences Neurotoxicology, signal-transduction systems in developmental neurotoxicity, molecular mechanisms of neurotoxicity, biochemical markers of neurotoxicity, children’s health, food additives and contaminants, genetic susceptibility, in vitro toxicology, pesticides and children, alcohol, cell-cell interactions in developmental neurotoxicity, toxicology of brominated flame retardants, neurotoxicity of diesel exhaust, paraoxonase 2, gender-differences in oxidative stress and neurotoxicity
Recommended by Scientific/Professional Society or General Public No

Charge to Peer Reviewers: DTEM Charge to Peer Reviewers  DTEM peer review policy

Additional elements to be added to the public posting as they become available
The ISI/HISA Dissemination Itself

Peer Reviewers’ Comments and CDC/ATSDR’s Response to Peer Reviewers’ Comments:2,4-D [PDF – 1 MB]