ATSDR - Toxic Substances - Toluene Diisocyanate Methylenediphenyl Diisocyanate
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Toluene Diisocyanate Methylenediphenyl Diisocyanate

CAS ID #: 26471-62-5, 584-84-9, 584-84-9

Affected Organ Systems: Respiratory (From the Nose to the Lungs)

Cancer Classification: EPA: Not evaluated. EPA: Not classifiable as to human carcinogenicity. IARC: Possibly carcinogenic to humans. NTP: Not evaluated. NTP: Reasonably anticipated to be a human carcinogen

Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification.

Chemical Classification: None

Summary: Toluene diisocyanate exists in two isomeric forms (2,4-toluene diisocyanate and 2,6-toluene diisocyanate) which have similar properties and effects. Toluene diisocyanate is produced commercially as an 80:20 (2,4-toluene diisocyanate:2,6-toluene diisocyanate) mixture of the two isomers. At room temperature, the mixture is a clear, pale yellow liquid with a sharp, pungent odor. It should be stored under refrigeration, away from light and moisture in a tightly closed container under an inert atmosphere. Toluene diisocyanate is insoluble in water and miscible with most common organic solvents.

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