Toxicological Profiles
Information About Contaminants Found at Hazardous Waste Sites
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Substance Index for ToxProfiles
* denotes tox profiles funded by the Department of Defense.
A
- Acetone (PB/95/100095/AS)
- Acrolein (Updated) (PB2008-100001)
- Acrylamide (Draft for Public Comments)
- Acrylonitrile (PB/91/180489/AS)
- Aldrin/Dieldrin (Updated) (PB2003-100134)
Aldrin, Dieldrin - Aluminum (Updated) (PB2009-100001)
- Americium (PB2004-104396)
- Ammonia (Updated) (PBPB2004-107331)
- Antimony (PB/93/110641/AS)
- Arsenic (Updated) (PB2008-100002)
- Asbestos (Updated) (PB/2001/109101)
- Atrazine (PB2004-100001)
B
- 1,3-Butadiene (Updated) (Draft for Public Comments)
- 2,3-Benzofuran (Draft for Public Comments)
- 2-Butanone (PB/93/110708/AS)
- 2-Butoxyethanol (PB/99/102527/AS)*
- Barium (Updated) (PB2008-100003)
- Benzene (Updated) (PB2008-100004)
- Benzidine (Updated) (PB/2001/109102)
- Beryllium (Updated) (PB2003-100135)
- Bis(2-chloroethyl) Ether (PB/90/168683/AS)
- Bis(chloromethyl) Ether (PB/90/168691/AS)
- Boron (Updated) (PB2010-100001)
- Bromodichloromethane (PB/90/167461/AS)
- Bromoform & Dibromochloromethane (Updated) (PB2006-100001)
- Bromomethane (PB/93/110682/AS)
C
- Cadmium (Updated) (Draft for Public Comments)
- Carbon Disulfide (Updated) (PB/97/121073/AS)
- Carbon Monoxide (Draft for Public Comments)
- Carbon Tetrachloride (Updated) (PB2006-100002)
- Cesium (PB2004-104397)
- Chlordane (Updated) (PB/95/100111/AS)
- Chlordecone (PB/95/264354)
- Chlorfenvinphos (PB/98/101116/AS)
- Chlorinated Dibenzo-p-dioxins (CDDs) (Updated) (PB/99/121998)
- Chlorine (PB2010-100002)
- Chlorine Dioxide & Chlorite (PB 2004-107332)
- Chlorobenzene (PB/91/180505/AS)
- Chlorodibenzofurans (CDFs) (PB/95/100129/AS)
- Chloroethane (Updated) (PB/99/121956)
- Chloroform (Updated) (PB/98/101140/AS)
- Chloromethane (Updated) (PB/99/121964)
- Chlorophenols (Updated) (PB/99/166639)
- Chlorpyrifos (PB/98/103088/AS)
- Chromium (Draft for Public Comments)
- Cobalt (Updated) (PB 2004-10733)
- Copper (Updated) (PB 2004-10733)
- Creosote (Updated) (PB2003-100136)
- Cresols (Updated) (PB2009-100002)
- Cyanide (Updated) (PB2007-100674)
D
- 1,1-Dichloroethane (PB/91/180539/AS)
- 1,1-Dichloroethene (Updated) (PB/95/100152/AS)
- 1,2-Dibromo-3-Chloropropane (PB/93/110906/AS)
- 1,2-Dibromoethane (PB/93/110740/AS)
- 1,2-Dichloroethane (Updated) (PB/2001/109103/AS)
- 1,2-Dichloroethene (Updated) (PB/97/121081/AS)
- 1,2-Dichloropropane (PB/90/182122/AS)
- 1,2-Diphenylhydrazine (Updated) (PB/91/180356/AS)
- 1,3 Dinitrobenzene & 1,3,5 Trinitrobenzene (PB/95/264289/AS)*
- 1,4-Dioxane (Draft for Public Comments)
- 2,4- & 2,6-Dinitrotoluene (Updated) (PB/99/122004)*
- 3,3'-Dichlorobenzidine (Updated) (PB/99/121980)
- DDT, DDE, DDD (Updated) (PB2003-100137)
- Di(2-ethylhexyl)phthalate (DEHP) (Updated) (PB2003-100138)
- Di-n-butyl Phthalate (Updated) (PB/2001/109104/AS)
- Di-n-octylphthalate (DNOP) (PB/98/101033/AS)*
- Diazinon (Updated) (PB2009-100003)
- Dichlorobenzenes (Updated) (PB2007-100672)
- Dichloropropenes (Updated) (PB2009-100004)
- Dichlorvos (PB/98/101124/AS)
- Diethyl phthalate (PB/95/264214/AS)*
- Diisopropyl Methylphosphonate (DIMP) (PB/99/102535/AS)*
- Dinitrocresols (Updated) (PB/95/264321)
- Dinitrophenols (PB/95/264339)
- Disulfoton (PB/95/264347)
E
- Endosulfan (Updated) (PB/2000/108023)
- Endrin/Endrin aldehyde (Updated) (PB/97/121040/AS)
- Ethion (PB/2000/108024)
- Ethylbenzene (PB2010-100004)
- Ethylene Glycol (PB2010-100005)
- Ethylene Oxide (PB/91/180554/AS)
F
- Fluorine, Hydrogen Fluoride, and Fluorides (Updated) (PB2004-100002)
- Formaldehyde (PB/99/166654)
- Fuel Oils / Kerosene (PB/95/264222/AS)*
H
- 2-Hexanone (Updated) (PB/93/110773/AS)
- Heptachlor/Heptachlor Epoxide (Updated) (PB2008-100005)
- Hexachlorobenzene (Updated) (PB2003-100139)
- Hexachlorobutadiene (PB/95/100160/AS)
- Hexachlorocyclohexane (HCH) (Updated) (PB2006-100003)
- Hexachlorocyclopentadiene (HCCPD) (PB/99/166670)
- Hexachloroethane (PB/98/101041/AS)*
- Hexamethylene Diisocyanate (HDI) (PB/99/102543/AS)*
- HMX (Octogen) (PB/98/101058/AS)*
- Hydraulic Fluids (PB/98/101066/AS)*
- Hydrazines (PB/98/101025/AS)*
- Hydrogen Sulfide (Updated) (PB2007-100675)
- n-Hexane (PB/99/166688)
M
- 4,4'-Methylenebis(2-Chloroaniline)(MBOCA) (PB/95/100186/AS)
- 4,4'-Methylenedianiline (PB/99/102568/AS)*
- Malathion (PB2004-100003)
- Manganese (Updated) (Draft for Public Comments)
- Mercury (Updated) (PB/99/142416)
- Methoxychlor (Updated) (PB2003-100140)
- Methyl Mercaptan (Draft for Public Comments)
- Methyl Parathion (PB/2001/109105/AS)
- Methyl tert-Butyl Ether (MTBE) (PB/97/121016/AS)
- Methylene Chloride (Updated) (PB/2000/108026)
- Mirex (PB/95/264354)
N
- n-Nitrosodi-n-propylamine (PB/90/180258/AS)
- n-Nitrosodimethylamine (PB/90/182130/AS)
- n-Nitrosodiphenylamine (Updated) (PB/93/182509/AS)
- Naphthalene, 1-Methylnapthalene, 2-Methylnapthalen (Updated) (PB2006-100004)
- Nickel (Updated) (PB2006-100005)
- Nitrobenzene (PB/91/180398/AS)
- Nitrophenols (PB/93/110823/AS)
P
- Pentachlorophenol (Updated) (PB/2001/109106/AS)
- Perchlorates (Updated) (PB2009-100006)
- Perfluoroalkyls (Draft for Public Comments)
- Phenol (Updated) (PB2009-100007)
- Phosphate Ester Flame Retardants (Draft for Public Comments)
- Plutonium (Updated) (PB2010-100006)
- Polybrominated Biphenyls (PBBs) & Polybrominated Diphenyl Ethers (PBDEs) (Updated) (PB2004-107334)
Aroclors -1260,-1254, -1248, -1242, -1232, -1221, and -1016 - Polychlorinated Biphenyls (PCBs) (Updated) (PB/2000/108027)
- Polycyclic Aromatic Hydrocarbons (PAHs) (Updated) (PB/95/264370)
Acenaphthene, Acenaphthylene, Anthracene, Benzo(a)anthracene, Benzo(a)pyrene, Benzo(b)fluoranthene, Benzo(g,h,i)perylene, Benzo(k)fluoranthene, Chrysene, Dibenzo(a,h)anthracene, Fluoranthene, Fluorene, Indeno(1,2,3-cd)pyrene, Phenanthrene, Pyrene - Propylene Glycol (Updated) (PB2009-103929)*
- Pyrethrins and Pyrethroids (PB2004-100004)
- Pyridine (PB/93/110831/AS)
S
- Selenium (Updated) (PB2004-100005)
- Silver (PB/91/180430/AS)
- Stoddard Solvent (PB/95/264263)*
- Strontium (PB2004-104400)
- Styrene (PB2010-100007)
- Sulfur Dioxide (PB/99/122020)
- Sulfur Mustard (Updated) (PB2004-100006)
- Sulfur Trioxide & Sulfuric Acid (PB99/122038)
- Synthetic Vitreous Fibers (PB2004-107335)
T
- 1,1,1-Trichloroethane (Updated) (PB/95/264396)
- 1,1,2,2-Tetrachloroethane (Updated) (PB2009-100008)
- 1,1,2-Trichloroethane (PB/90/196411/AS)
- 1,2,3 Trichloropropane (PB/93/110872/AS)
- 1,3,5 Trinitrobenzene & 1,3 Dinitrobenzene (PB/95/264289/AS)*
(See 1,3-Dinitrobenzene) - 2,4,6-Trinitrotoluene (TNT) (PB/95/264297/AS)*
- Tetrachloroethylene (PERC) (Updated) (PB/98/101181/AS)
- Tetryl (PB/95/264271/AS)*
- Thallium (PB/93/110856/AS)
- Thorium (PB/91/180448/AS)
- Tin and Compounds (Updated) (PB2006-100006)
- Titanium Tetrachloride (PB/98/101082/AS)*
- Toluene (Updated) (PB/2000/108028)
- Total Petroleum Hydrocarbons (TPH) (PB/99/163370)
- Toxaphene (Updated) (PB/97/121057/AS)
- Trichlorobenzenes (Draft for Public Comments)
- Trichloroethylene (TCE) (Updated) (PB/98/101165/AS)
- Tungsten (PB2006-100007)
U
- Natural and Depleted Uranium (Updated) (Draft for Public Comment)
- Used Mineral-based Crankcase Oil (PB/98/101074/AS)*
V
- Vanadium and Compounds (Draft for Public Comments)
- Vinyl Acetate (PB/93/110898/AS)
- Vinyl Chloride (Updated) (PB2007-100671)
Background
By Congressional mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) produces "toxicological profiles" for hazardous substances found at National Priorities List (NPL) sites. These hazardous substances are ranked based on frequency of occurrence at NPL sites, toxicity, and potential for human exposure. Toxicological profiles are developed from a priority list of 275 substances. ATSDR also prepares toxicological profiles for the Department of Defense (DOD) and the Department of Energy (DOE) on substances related to federal sites.
So far, 314 toxicological profiles have been published or are under development as “finals” or “drafts for public comment”; 290 profiles were published as finals; 136 profiles have been updated. Currently, 11 profiles are being revised based on public comments received; 6 profiles under development These profiles cover more than 250 substances.
Toxicological profiles are developed in two stages:
(1) DRAFTS: The toxicological profiles are first produced as drafts. ATSDR announces in the Federal Register the release of these draft profiles for a 90 day public comment period. Request draft toxicological profiles from ATSDR's Division of Toxicology and Environmental Medicine.
(2) FINALS: After the 90 day comment period, ATSDR considers incorporating all comments into the documents. ATSDR finalizes the profiles and the National Technical Information Service (NTIS) distributes them.
ATSDR's toxicological mailing list
Congress requires ATSDR (1) to provide toxicological profiles to state health and environmental agencies and (2) to make them available to other interested parties. The Division of Toxicology and Environmental Medicine (DTEM) has a mailing list, which is updated and verified yearly, of groups and individuals who get free copies of both draft and final profiles; these include health professionals at federal, state, and local levels; academicians; nonprofit/environmental groups; members of the public involved with Superfund sites; and parties with special needs (considered case-by-case).
If you don't qualify for free copies, you may request final profiles from NTIS for a fee.
NTIS address
NTIS distributes finalized toxicological profiles for a
fee. For more information, contact
National Technical Information Service
5285 Port Royal Road
Springfield, Virginia 22161
1-800-553 6847 or 703-605-6000
Web site: http://www.ntis.gov
Draft Profiles
Toxicological profiles "Draft for Public Comment" - CERCLA Set 22
- Cadmium (Update)
- Chromium (Update)
- Manganese (Update)
- Radon (Update)
- 1,4-Dioxane (Update)
The public comment period has ended and the profiles will be revised based on relevant public comments
The following profiles is currently under review
- Formaldehyde (Update)
- Perfluoroalkyls
Toxicological profiles "Draft for Public Comment" - CERCLA Set 23
- Acrylamide
- 1,3-Butadiene (Update)
- Carbon Monoxide
- Phosphate Ester Flame Retardants
- Vanadium (Update)
The public comment period has ended and the profiles will be revised based on relevant public comments
Toxicological profiles "Draft for Public Comment" - CERCLA Set 24
- Trichlorobenzenes
- Toxaphene (Update)
The public comment period has ended and the profiles will be revised based on relevant public comments.
Toxicological profiles "Draft for Public Comment"
- Uranium (Update)
The public comment period has ended and the profile will be revised based on relevant public comments.
Editor’s note: CERCLA is the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (Superfund).
Toxicological profiles (under development) – CERCLA Set 25
The public comment period has ended and the profile will be revised based on relevant public comments.
Editor’s note: CERCLA is the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (Superfund).
List updated on February 16, 2012
Federal Register Notices:
- FRN RDX [PDF, 51 KB]
- FRN Uranium [PDF, 52 KB]
- FRN Set 24 Drafts for Public Comment [PDF, 46 KB]
- FRN Set 21 Final Profiles [PDF, 42 KB]
- Profile Development Guidance [PDF, 2 MB]
- Profile Development Guidance Exhibits [PDF, 1 MB]
- Profile Selection Criteria
- Federal Register Notice[PDF, 964 KB]
- Support Document [PDF, 2.6 MB]
Additional Resources:
- ATSDR ToxProfiles™ CD-ROM - The toxicological profiles are also available as a complete set on CD-ROM.
- Public Health Statements (PHS) - The PHS are a series of summaries about hazardous substances taken from Chapter One of their respective ATSDR Toxicological Profiles.
- ATSDR ToxFAQs™ - The ToxFAQs™ are a series of 2-page fact sheets about hazardous substances
- ATSDR ToxGuides - The ATSDR ToxGuides™ are quick reference guides providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects.
To request a copy of the ToxProfiles™ CD-ROM, PHS, or ToxFAQs™ call 1-800-CDC-INFO (800-232-4636) or email your request to cdcinfo@cdc.gov.
For more information on the above listed publications, write
Further information can be obtained by contacting the ATSDR Information Center at:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Environmental Medicine
1600 Clifton Road NE, Mailstop F-62
Atlanta, GA 30333
Phone: 1-800-CDC-INFO 888-232-6348 (TTY)
Email: cdcinfo@cdc.gov
For more information
You may call the ATSDR toll free number at 1-800-CDC-INFO (800-232-4636) or 1-888-232-6348 (TTY) to get information about Division of Toxicology and Environmental Medicine programs.
ATSDR Internet home page via World Wide Web: http://www.atsdr.cdc.gov
The profiles, public health statements, ToxFAQs™ and other information are available on the Internet.
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