Interaction Profile for Selected Metallic Ions Identified in Waste Water from Unconventional Oil and Gas Extraction Activities

Draft Interaction Profile - August 2023

Draft for Public Comment
Comments may be submitted via
Public Comment Period Closes on November, 2023


  • Barium 7440-39-3
  • Calcium 7440-70-2
  • Iron 7439-89-6
  • Magnesium 7439-95-4
  • Manganese 7439-96-5
  • Sodium 7440-23-5
  • Strontium 7440-24-6

Complete Profile [PDF – 4 MB]

  • The table of contents and list of individual PDF files are given below.

Preface [PDF – 924 KB]

  • Summary
  • Contributors
  • Peer review
  • Contents
  • List of figures
  • List of tables
  • List of acronyms, abbreviations, and symbols

Introduction [PDF – 885 KB]

Interaction Data for the Mixture [PDF – 1 MB]

  • 2.1 Mixture of Concern
  • 2.2 Component Mixtures

Recommendation for Exposure-Based Assessment of Joint Toxic Action of the Mixture, [PDF – 1,011 KB]

Conclusions [PDF – 827 KB]

List of References [PDF – 813 KB]

Appendices [PDF – 1 MB]

  • A. Background Information for Barium
  • B. Background Information for Calcium
  • C. Background Information for Iron
  • D. Background Information for Magnesium
  • E. Background Information for Manganese
  • F. Background Information for Sodium
  • G. Background Information for Strontium
  • H. Noncancer Health Guidance Values for Selected Metals
  • I. Mixtures of Inorganic Components Identified in Waste Water from Unconventional Gas Extraction Activities
  • J. Database Query Strings for Combinations of Selected Metallic Ions (Barium, Calcium, Iron, Magnesium, Manganese, Sodium, and Strontium)

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Agency for Toxic Substances and Disease Registry (ATSDR). 2023. Interaction Profile for Selected Metallic Ions  (Draft for Public Comment). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.


All ATSDR Interaction Profile PDF files are electronic conversions other electronic text files. This conversion may have resulted in character translation or format errors.

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