Toxicological Profile for Uranium

Title: Toxicological Profile for Uranium

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): February 2011

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment in April 2011.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3 or fewer

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Charge to Peer Reviewers: DTEM Charge to Peer Reviewers

1. Fletcher F. Hahn
1. Fletcher F. Hahn
Academic and Professional Credentials Ph.D., Comparative Pathology, University of California- Davis
D.V.M., Veterinary Medicine, Washington State University
B.S., Biological Sciences, Washington State University
Current Position Title Scientist Emeritus
Organizational Affiliation(s) Lovelace Respiratory Research Institute, Albuquerque, NM
Areas of Expertise, Discipline, Relevant
Experiences
Dr. Hahn has extensive expertise in radiation, inhalation exposures, animal models, depleted uranium, and pulmonary toxicology.
Recommended by Scientific/Professional
Society or General Public
No
2. Walter W. Piegorsch
2. Walter W. Piegorsch
Academic and Professional Credentials Ph.D., Statistics, Cornell University
M.S., Statistics, Cornell University
B.A., Mathematics, Colgate University
Current Position Title Chair, Graduate Interdisciplinary Program in Statistics
Organizational Affiliation(s) University of Arizona, Tucson, AZ
Areas of Expertise, Discipline, Relevant Experiences Dr. Piegorsch is a statistician with extensive experience analyzing environmental health data and application of benchmark dose modeling. He has knowledge of uranium and uranium compounds’ physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, and quantification of risk to humans.
Recommended by Scientific/Professional
Society or General Public
No
3. Rudolfs K. Zalups
3. Rudolfs K. Zalups
Academic and Professional Credentials Ph.D., Human Anatomy and Cell Biology, University of Western Ontario
M.S., Zoology, State University of New York
B.S., Mathematics, State University of New York
Current Position Title Professor, Histology
Organizational Affiliation(s) Mercer University School of Medicine
Areas of Expertise, Discipline, Relevant Experiences Dr. Zalups has expertise in the area of cellular and molecular biology and the toxiclogy of heavy metals such as uranium. Much of his work focuses on the mechanisms by which select environmental toxicants affect the kidneys.
Recommended by Scientific/Professional
Society or General Public
No

Peer Reviewers’ Comments: Uranium Report pdf icon[PDF – 4 MB]

CDC/ATSDR’s Response to Peer Reviewers’ Comments: Uranium Formal Disposition pdf icon[PDF – 96 KB]

The ISI/HISA Dissemination Itself

Page last reviewed: August 18, 2015