Table of Contents
Prepared for:
Agency for Toxic Substances and Disease Registry
Division of Health Assessment and Consultation
Atlanta, GA
Prepared by:
Eastern Research Group, Inc.
110 Hartwell Avenue
Lexington , MA 02421
March 17, 2003
TABLE OF CONTENTS
1.1 Background
1.2 Scope of the Expert Panel Review
1.2.1 Activities Prior to the Expert Panel Meeting
1.2.2 Activities at the Expert Panel Meeting
1.2.3 Activities Following the Expert Panel Meeting
1.3 Report Organization
1.2 Scope of the Expert Panel Review
1.2.1 Activities Prior to the Expert Panel Meeting
1.2.2 Activities at the Expert Panel Meeting
1.2.3 Activities Following the Expert Panel Meeting
1.3 Report Organization
2.1 Depositional Pattern in the Lung
2.2 Lung Clearance and Biopersistence
2.3 Migration of Fibers Deposited in the Lung
2.4 Open Discussion Among Panelists
2.5 Observer Comments and Ensuing Discussions
2.2 Lung Clearance and Biopersistence
2.3 Migration of Fibers Deposited in the Lung
2.4 Open Discussion Among Panelists
2.5 Observer Comments and Ensuing Discussions
3.0 Comments on Topic 2: Health Effects of Asbestos and SVF Less Than 5 Micrometers in Length
3.1 Cancer Effects
3.1.1 Data from Cancer Mortality Studies
3.1.2 Data from Human Studies of Lung-Retained Fibers (Cancer)
3.1.3 Data from Laboratory Animal Studies (Cancer)
3.2 Noncancer Effects
3.2.1 Data from Occupational Studies
3.2.2 Data from Human Studies of Lung-Retained Fibers (Noncancer)
3.2.3 Data from Laboratory Animal Studies (Noncancer) 3.3 Mechanisms of Toxicity
3.4 General Comments and Interpretations
3.5 Research Needs
3.6 Observer Comments and Ensuing Discussions
3.1.1 Data from Cancer Mortality Studies
3.1.2 Data from Human Studies of Lung-Retained Fibers (Cancer)
3.1.3 Data from Laboratory Animal Studies (Cancer)
3.2 Noncancer Effects
3.2.1 Data from Occupational Studies
3.2.2 Data from Human Studies of Lung-Retained Fibers (Noncancer)
3.2.3 Data from Laboratory Animal Studies (Noncancer) 3.3 Mechanisms of Toxicity
3.4 General Comments and Interpretations
3.5 Research Needs
3.6 Observer Comments and Ensuing Discussions
4.0 Conclusions and Recommendations
Appendix A: List of Expert Panelists
Appendix C: List of Registered Observers of the Expert Panel Meeting
Appendix D: Agenda for the Expert Panel Meeting
Appendix E: Panelists’ Comments Submitted After the Meeting
Contact Us:
- Agency for Toxic Substances and Disease Registry
4770 Buford Hwy NE
Atlanta, GA 30341-3717 USA - 800-CDC-INFO
(800-232-4636)
TTY: (888) 232-6348
Email CDC-INFO - New Hours of Operation
8am-8pm ET/Monday-Friday
Closed Holidays
