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Toxicological Profile for Total Petroleum Hydrocarbons

Toxicological Profile PDF PDF Version, 4.8 MB

Toxicological Profile Information

The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The complete list of topics covered (chapter titles) is shown at the left and in more detail further down this page.

The focus of the profile is on health and toxicologic information. Therefore, each profile begins with a Public Health Statement that summarizes in nontechnical language, a substance's relevant properties.

A useful two page information sheet, the ToxFAQsTM, is also available.

Toxicological Profile Access

In order to access the ATSDR toxicological profiles' PDF files below, you must have Adobe Acrobat Reader.

You may download that program for free from this link to Adobe and then use it to access (open) the files below that are labeled as PDF files.

Toxicological Profile PDF Complete Profile, 4.8 MB

The table of contents and list of individual PDF files are given below.

Preface PDF Preface, 818 KB

  • Foreword
  • Contributors
  • Peer review
  • List of figures
  • List of tables

Public Health Statement PDF 1. Public Health Statement, 114 KB

1.1 What is this substance?
1.2 What happens to it when it enters the environment?
1.3 How might I be exposed to it?
1.4 How can it enter and leave my body?
1.5 How can it affect my health?
1.6 Is there a medical test to determine whether I have been exposed to it?
1.7 What recommendations has the federal government made to protect human health?
1.8 Where can I get more information?

Overview of Total Petroleum Hydrocarbons (TPH) PDF 2. Overview of Total Petroleum Hydrocarbons (TPH), 219 KB

2.1 Definition of substance
2.2 Total substance analysis overview
2.3 TPH fractions and the ATSDR approach to evaluating the public health implications of exposure to TPH

Identity and Analysis of Total Petroleum Hydrocarbons PDF 3. Identity and Analysis of Total Petroleum Hydrocarbons, 647 KB

3.1 Introduction
3.2 Chemical and physical information
3.3 Analytical methods

Production, Import, Use, and Disposal PDF 4. Production, Import, Use, and Disposal, 354 KB

Potential for Human Exposure PDF 5. Potential for Human Exposure, 880 KB

5.1 Overview
5.2 Releases to the environment
5.3 Fate and transport
5.4 Levels in the environment
5.5 Adequacy of the database

Health Effects PDF 6. Health Effects, 2.4 MB

6.1 Introduction
6.2 Discussion of health effects by route of exposure
6.3 Discussion of health effects
6.4 Toxicokinetics
6.5 Mechanisms of action
6.6 Selection of fraction-specific health effects criteria
6.7 Relevance to public health
6.8 Biomarkers of exposure and effect
6.9 Interactions with other substances
6.10 Populations that are unusually susceptible
6.11 Methods for reducing toxic effects
6.12 Adequacy of the database

Regulations and Advisories PDF 7. Regulations and Advisories, 394 KB

References PDF 8. References, 181 KB

Glossary PDF 9. Glossary, 144 KB

Appendices PDF Appendices, 3.1 MB

A. MRLs and cancer classification for the TPH components and whole products
B. User's guide
C. Acronyms, abbreviations, and symbols
D. Petroleum product compostion
E. Identity, components, and chemical/physical properties of selected petroluem products


Agency for Toxic Substances and Disease Registry (ATSDR). 1999. Toxicological profile for Total Petroleum Hydrocarbons (TPH). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.


All ATSDR toxicological profile PDF files are electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the toxicological profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the toxicological profile home page, which also contains other important information about the profiles.

Where can I get more information?

If you have questions or concerns, please contact your community or state health or environmental quality department or:

For more information, contact:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
1600 Clifton Road NE, Mailstop S102-1
Atlanta, GA 30333
Phone: 1-800-CDC-INFO · 888-232-6348 (TTY)
Email: Contact CDC-INFO

ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.

Contact Us:
  • Agency for Toxic Substances and Disease Registry
    4770 Buford Hwy NE
    Atlanta, GA 30341
  • 800-CDC-INFO
    TTY: (888) 232-6348
  • New Hours of Operation
    8am-8pm ET/Monday-Friday
    Closed Holidays
    Contact CDC-INFO The U.S. Government's Official Web PortalDepartment of Health and Human Services
Agency for Toxic Substances and Disease Registry, 4770 Buford Hwy NE, Atlanta, GA 30341
Contact CDC: 800-232-4636 / TTY: 888-232-6348

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