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Guidance Manual Information

Assessment of Joint Toxic Action of Chemical Mixtures - May 2004

Complete Manual [577KB]This is the whole manual in one large PDF file.
The table of contents and list of individual PDF files are given below.

Preface [5KB]

  • Summary
  • Contributors
  • Peer review
  • Contents
  • List of figures
  • List of tables
  • List of acronyms, abbreviations, and symbols
  • Executive Summary

Chapter 1 [28k]Overview

Chapter 2 [125k] Options and Issues for the Assessment of Joint Toxic Action of Chemical Mixtures

Chapter 3 [26k]Methods Used or Proposed by Other Agencies

Chapter 4 [137k]ATSDR Approach

Chapter 5 [34k]References

Appendices [259k]

  • A. Background Information on the assessment of additivity and interactions
  • B. Weight-of-Evidence methods
  • C. The integral search system for ranking hazards of mixtures of carcinogens

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Agency for Toxic Substances and Disease Registry (ATSDR). 2004. Guidance manual for the assessment of joint toxic actions of chemical mixtures. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.


All ATSDR Interaction Profile PDF files are electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the interaction profile for the official text, figures, and tables. Interaction Profiles Home Page, contains other important information about the profiles.

Where can I get more information?

ATSDR can tell you where to find occupational and environmental health clinics. Their specialists can recognize, evaluate, and treat illnesses resulting from exposure to hazardous substances. You can also contact your community or state health or environmental quality department if you have any more questions or concerns.

For more information, contact:

Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
1600 Clifton Road NE, Mailstop F-57
Atlanta, GA 30333
Phone: 1-800-CDC-INFO • 888-232-6348 (TTY)

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