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Toxicological Profile for Perfluoroalkyls (PFAS)

Title: Toxicological Profile for Perfluoroalkyls

Subject of planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: HISA

Timing of Review (including deferrals): November 2014 and August 2017

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when):  A draft of this profile will be made available for public comment in 2015.  A draft of the revised profile will be made available for public comment in 2018.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. Emmett, Edward

Academic and Professional Credentials MD, MS
Current Position Title Professor, Director of Academic Programs in Occupational Medicine
Organizational Affiliation(s) Center of Excellence in Environmental Toxicology
University of PennsylvaniaPhiladelphia, Pennsylvania 19104
Areas of Expertise, Discipline, Relevant Experiences occupational and environmental skin diseases, ultraviolet radiation effects on skin and eyes, the toxicity of polyaromatic hydrocarbons, PCBs, organometals, monomers used in plastics and resins, and other subjects. He is a recipient of the Kehoe Award of Merit from the American College of Occupational and Environmental Medicine.
Recommended by Scientific/Professional Society or General Public No

2. Cory-Slechta, Deborah A

Academic and Professional Credentials PhD
Current Position Title Professor
Organizational Affiliation(s) Department of Environmental Medicine
University of Rochester School of Medicine
Areas of Expertise, Discipline, Relevant Experiences the relationships between brain neurotransmitter systems and children’s neurodevelopment, and how such relationships are altered by exposures to environmental toxicants, including the role played by environmental neurotoxicant exposures in developmental disabilities and neurodegenerative diseases.
Recommended by Scientific/Professional Society or General Public No

3. Hayton, William L

Academic and Professional Credentials PhD
Current Position Title Professor Emeritus
Organizational Affiliation(s) College of Pharmacy
Ohio State University
Columbus, Ohio
Areas of Expertise, Discipline, Relevant Experiences pharmacokinetics, particularly the construction and validation of mathematical models that describe or explain the kinetics of complex biological systems; interspecies scaling of pharmacokinetic model parameter values and xenobiotic metabolism
Recommended by Scientific/Professional Society or General Public No

4. deWitt, Jamie

Academic and Professional Credentials PhD
Current Position Title Associate Professor
Organizational Affiliation(s) Department of Pharmacology & Toxicology
Brody School of Medicine
East Carolina University
Areas of Expertise, Discipline, Relevant Experiences Environmental and neural science, environmental toxicology, immunotoxicology. Her environmental developmental neuroimmunotoxicology research program explores relationships between biological organisms and their developmental responses after exposure to environmental toxicants. Special emphasis research on early life exposure to a variety of agents that may affect the immune, nervous, and endocrine systems, resulting in altered development such as disease or disorder in childhood or later in life. Her expertise lies in how impacts on the immune system lead to downstream effects on the nervous system. She has numerous publications and research in the area of PFAS.
Recommended by Scientific/Professional Society or General Public No

5. Savitz, David A

Academic and Professional Credentials PhD
Current Position Title Professor of Epidemiology
Organizational Affiliation(s) Brown University School of Public Health, with a joint appointment in Obstetrics and Gynecology in the Alpert Medical School, Providence, RI
Areas of Expertise, Discipline, Relevant Experiences Environmental hazards in the workplace and community, reproductive health outcomes, and environmental influences on cancer. He has done extensive work on health effects of nonionizing radiation, pesticides, drinking water treatment by-products, and perfluorinated compounds. He has directed 30 doctoral dissertations and 15 master’s theses; authored nearly 350 papers in professional journals and editor or author of three books. He has served as editor at the American Journal of Environmental hazards in the workplace and community, reproductive health outcomes, and environmental influences on cancer. He has done extensive work on health effects of nonionizing radiation, pesticides, drinking water treatment by-products, and perfluorinated compounds. He has directed 30 doctoral dissertations and 15 master’s theses; authored nearly 350 papers in professional journals and editor or author of three books. He has served as editor at the American Journal of Epidemiology and as a member of the Epidemiology and Disease Control-1 study section of the National Institutes of Health and currently is an editor at Epidemiology. He was President of the Society for Epidemiologic Research and the Society for Pediatric and Perinatal Epidemiologic Research and North American Regional Councilor for the International Epidemiological Association. Dr. Savitz is a member of the National Academy of Sciences Institute of Medicine. From 2013-2017 he served as Vice President for Research at Brown University.
Recommended by Scientific/Professional Society or General Public No

Charge to Peer Reviewers: Charge to Peer Reviewers

CDC/ATSDR’s Response to Reviewers’ Comments: 2014 Tox profile Perfluoroalkyls Formal Disposition [PDF – 664 KB]

Perfluoroalkyls Responses to peer reviewer comments 2018 Tox profile [PDF – 1 MB]

The ISI/HISA Dissemination Itself

The 2018 ISI/HISA Dissemination Itself

Additional elements for the 2018 update to be added to the public posting as they become available

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