Approach for Toxicological Evaluation Discussion

Throughout this primer, we will explain what is involved in each step of the toxicological evaluation process.

After you learn about each step, we will use our case study example to demonstrate how to perform that step. This is similar to what we did in other steps of Module 7.

When we are going to do an example, those slides will say “Practice” in the title. For practice, we will walk through each step using our class exercises from previous steps in Module 7, where we identified certain exposure scenarios requiring further evaluation in the toxicological evaluation.

As you recall from the previous steps (Steps 1–6) in Module 7, we identified certain exposure scenarios from our training exercises that required a toxicological evaluation. We will evaluate those here.

• First, we will practice together. We will conduct a toxicological evaluation for the estimated exposure doses and cancer risks for residents drinking carbon tetrachloride contaminated water from PW-3 over a chronic duration that exceeded HQs of 1 and CRs of 1.0E-6, respectively.
• Then, you will do a case study exercise. You will conduct a toxicological evaluation for estimated exposure doses and cancer risks associated with arsenic in soil at the daycare that exceeded HQs of 1 and CRs of 1.0E-6, respectively. In addition, a toxicological evaluation is needed to evaluate the intermediate pica exposures, because no intermediate duration health guideline is available.