Main Steps of the Toxicological Evaluation

Identify data from key studies used to develop noncancer health guidelines.

Review the original journal article(s) that served as the basis for the noncancer health guidelines and more recent studies, if needed.

Evaluate the evidence to examine noncancer effects.

Evaluate the evidence to examine cancer effects.

Review toxicological information for other health effects (target organs and systems) with doses or air concentrations like those for your site. Compare site doses or air concentrations to the Levels of Significant Exposure (LSE) tables/figures in the ATSDR Toxicological Profile.

Review other contaminant-specific information that might influence a decision about whether harmful effects are possible.

Consult with a team toxicologist or epidemiologist to help interpret or identify information.