Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options

Summary Report Hair Analysis Panel Discussion Exploring The State Of The Science

Hair Analysis Panel Discussion: Section 7.0,
Figure 7-1

Historical Document

This Web site is provided by the Agency for Toxic Substances and Disease Registry (ATSDR) ONLY as an historical reference for the public health community. It is no longer being maintained and the data it contains may no longer be current and/or accurate.

Figure 7-1. Evaluation and Solution of Environmental and Occupational Health Problems: Critical Analysis in Practice1

Model: Cause-Effect






Indicators of exposure and effects

Substances known to be present at site

Potential dose

External dose

Internal dose


Disease or other health effect

Possible detectable or measurable parameters

Inventories of raw materials, byproducts, and final products

Concentrations in air, soil, water, and surface wipe samples

Personal air samples, wipe samples of skin, hair analysis; dosimetry

Concentrations in blood, urine, and other body tissues and fluids; dosimetry

or other indicators

Bio-markers or other indicators

Type of assessment

Document review




Biological and other




• Hypothesis or problem statement clearly defined
• Scientific plausibility (e.g.,toxicity, biokinetics, relationship between time of exposure and time of assessment)
• Motives and desired results

• application of scientific methods to research theoretical questions
• application of available scientific knowledge to provide answers to questions from the public

Public health criteria and study design

• Selected parameters to be measured are valid with respect to the model
• Interpretation possible (e.g., dose-response relationship, population norms, intra- and interindividual variability)
• Relevance of interpretation to the problem statement (e.g., prevention possible) or to questions from the public (e.g., predictive value, risk communication)
• Feasibility (technical feasibility and cost feasibility)
• Timeliness
• Ethics

and handling

• Contamination
• Stability during transport or storage
• Preparation methods (e.g., cleaning, digestion)


• Validity, reliability, accuracy, precision, sensitivity, specificity
• Quality control (proficiency tests, coefficient of variation)

1Dr. Kawamoto provided this schematic following the meeting, as a work in progress, as a visual display of the various concepts presented as part of the panel discussions. It is an expanded version of a hand-drawn figure presented at the meeting.

Top of Page

Contact Us:
  • Agency for Toxic Substances and Disease Registry
    4770 Buford Hwy NE
    Atlanta, GA 30341-3717 USA
  • 800-CDC-INFO
    TTY: (888) 232-6348
    Email CDC-INFO
  • New Hours of Operation
    8am-8pm ET/Monday-Friday
    Closed Holidays The U.S. Government's Official Web PortalDepartment of Health and Human Services
Agency for Toxic Substances and Disease Registry, 4770 Buford Hwy NE, Atlanta, GA 30341
Contact CDC: 800-232-4636 / TTY: 888-232-6348

A-Z Index

  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #