PUBLIC HEALTH ASSESSMENT
BRANDYWINE DEFENSE REUTILIZATION AND MARKETING OFFICE
ANDREWS, PRINCE GEORGE'S COUNTY, MARYLAND
APPENDIX A: ATSDR PLAIN LANGUAGE GLOSSARY OF ENVIRONMENTAL HEALTH TERMS
ATSDR defines an exposure pathway as having 5 parts:
When all five parts of an exposure pathway are present, it is called a Completed Exposure Pathway. Each of these five terms is defined in this Glossary.
APPENDIX B: ESTIMATES OF HUMAN EXPOSURE DOSES AND DETERMINATION OF HEALTH EFFECTS
Overview of ATSDR's Methodology for Evaluating Potential Public Health Hazards
ATSDR evaluated exposures to groundwater, surface soil, surface water and sediment, and air at Brandywine Defense Reutilization and Marketing Office (DRMO). To do so, ATSDR evaluated available data to determine whether contaminants were above ATSDR's comparison values (CVs). For those that were, ATSDR derived exposure doses and compared them against health-based guidelines. ATSDR also reviewed relevant toxicological data to obtain information about the toxicity of contaminants of interest.
Comparing Data to ATSDR's CVs
CVs are derived by use of conservative exposure assumptions. CVs reflect concentrations that are much lower than those that have been observed to cause adverse health effects. Thus, CVs are protective of public health in essentially all exposure situations. As a result, concentrations detected at or below ATSDR's CVs are not considered to warrant health concern. While concentrations at or below the relevant CV may reasonably be considered safe, it does not automatically follow that any environmental concentration that exceeds a CV would be expected to produce adverse health effects. It cannot be emphasized strongly enough that CVs are not thresholds of toxicity. The likelihood that adverse health outcomes will actually occur depends on site-specific conditions and individual lifestyle and genetic factors that affect the route, magnitude, and duration of actual exposure, and not on environmental concentration alone.
For this public health assessment, ATSDR evaluated data that were collected from groundwater, surface water and sediment, and surface soil to determine whether people were exposed to contaminant concentrations that exceeded ATSDR's CVs. The majority of detected contaminants fell at or below CVs and were not evaluated further. Contaminants that were above CVs were deemed worthy of further evaluation, prompting ATSDR to estimate exposure doses (i.e., the amount of chemical a person is exposed to over time) using site-specific exposure assumptions.
Deriving Exposure Doses
ATSDR derived exposure doses for those contaminants that were detected above ATSDR's CVs or did not have CVs. When estimating exposure doses, health assessors evaluate contaminant concentrations to which people may have been exposed and length of time and the frequency of exposure. Together, these factors influence an individual's physiological response to chemical contaminant exposure and potential outcomes. Where possible, ATSDR used site-specific information about the frequency and duration of exposures. In cases where site-specific information was not available, ATSDR applied several conservative exposure assumptions to estimate exposures for off-site residents.
The following equation was used to estimate exposure to contaminants in groundwater:
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where:
Conc.: Maximum concentration in parts per million (ppm) IR: Ingestion rate: adult = 2 liters per day; child = 1 liter per day EF: Exposure frequency, or number of exposure events per year of exposure: 365 days/year ED: Exposure duration, or the duration over which exposure occurs: adult = 30 years; child = 6 years BW: Body weight: adult = 70 kg; child = 10 kg AT: Averaging time, or the period over which cumulative exposures are averaged (6 years or 30 years x 365 days/year for noncancer effects; 70 years x 365 days/year for cancer effects)
The following equation was used to estimate recreational exposure to contaminants in surface water:
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where:
Conc.: Maximum concentration in ppm IR: Ingestion rate: 0.15 liters per day § EF: Exposure frequency, or number of exposure events per year of exposure: 130 days/year ED: Exposure duration, or the duration over which exposure occurs: adult = 30 years; child = 6 years BW: Body weight: adult = 70 kg; child = 23 kg* AT: Averaging time, or the period over which cumulative exposures are averaged (6 years or 30 years x 365 days/year for noncancer effects; 70 years x 365 days/year for cancer effects)
§ The ingestion rate is based on swimming for 3 hours per event (EPA 1997).
* ATSDR assumed that children under the age of 6 would not be expected to play in the stream.
The following equation was used to estimate exposure to contaminants in soil:
![]()
where:
Conc.: Average concentration in ppm IR: Ingestion rate: adult = 100 milligrams (mg) per day; child = 200 mg per day EF: Exposure frequency, or number of exposure events per year of exposure: 130 days/year ED: Exposure duration, or the duration over which exposure occurs: adult = 30 years; child = 6 years BW: Body weight: adult = 70 kg; child = 23 kg* AT: Averaging time, or the period over which cumulative exposures are averaged (6 years or 30 years x 365 days/year for noncancer effects; 70 years x 365 days/year for cancer effects)
* ATSDR assumed that children under the age of 6 would probably not play in the area outside Brandywine DRMO.
Using Exposure Doses to Evaluate Potential Health Hazards
ATSDR performs weight of evidence analyses to determine whether exposures might be associated with adverse health effects (noncancer and cancer). As part of this process, ATSDR examines relevant toxicologic, medical, and epidemiologic data to determine whether estimated doses are expected to result in adverse health effects. As a first step in evaluating noncancer effects, ATSDR compares estimated exposure doses to standard health guideline values, including ATSDR's minimal risk levels (MRLs) and the US Environmental Protection Agency's (EPA's) reference doses (RfDs). The MRLs and RfDs are estimates of daily human exposure to a substance that is not expected to result in noncancer effects over a specified duration. Estimated exposure doses that are less than these values are not considered to be of health concern. To be very protective of human health, MRLs and RfDs have built in "uncertainty" or "safety" factors that make them much lower than levels at which health effects have been observed. Therefore, if an exposure dose is higher than the MRL or RfD, it does not necessarily follow that adverse health effects will occur.
If health guideline values are exceeded, ATSDR examines the effect levels seen in the literature and more fully reviews exposure potential to help predict the likelihood of adverse health outcomes. ATSDR looks at human studies, when available, as well as experimental animal studies. This information is used to describe the disease-causing potential of a particular contaminant and compare site-specific dose estimates with doses shown to result in illness in applicable studies (known as the margin of exposure). For cancer effects, ATSDR also reviews genotoxicity studies to further understand the extent to which a contaminant might be associated with cancer outcomes. This process enables ATSDR to weigh the available evidence, in light of uncertainties, and offer perspective on the plausibility of adverse health outcomes under site-specific conditions.
Evaluation of Health Hazards Associated with Brandywine DRMO
ATSDR identified several pathways that had the potential to lead to exposures to people living at or visiting areas around Brandywine DRMO (see Table 1). For each of these potential pathways, contaminant concentrations were compared to CVs when the data were available. Many of the contaminants were detected below their corresponding CVs. For each pathway in which chemicals were detected above CVs or did not have CVs, exposure doses were calculated. With the exception of PCBs in soil, all exposure doses were less than their respective MRLs and RfDs; therefore, none of the chemicals were detected at levels of health concern in any of the evaluated pathways. More detail about each of the exposure pathways follows.
Groundwater
In only once instance was exposure to contaminated groundwater occurring--trichloroethylene (TCE) was detected above its CV in one residential drinking water well in 1989. ATSDR calculated conservative exposure doses by using the equations and assumptions described above based on the maximum concentration detected in this well (10 ppb). The resulting doses [0.0003 milligrams per kilogram per day (mg/kg/day) for adults and 0.001 mg/kg/day for children] were below EPA's RfD of 0.006 mg/kg/day. Therefore, the levels were too low to be of health concern.
Surface Water and Sediment
Surface water and sediment were sampled from the off-site drainage ditch and on site in 1990 and 1993/1994. None of the sediment samples were detected above CVs; therefore, no exposure doses were calculated because exposure to sediment is not at a level of health concern. In surface water, two contaminants were detected above CVs (chlordane and lead) and one did not have a CV (Aroclor-1260). ATSDR calculated exposure doses for chlordane and Aroclor-1260. Lead is examined differently and will be discussed below. The expected exposures to chlordane (0.000001 mg/kg/day for adults and 0.000004 mg/kg/day for children) were well below EPA's RfD of 0.0005 mg/kg/day. Aroclor-1260 does not have an MRL or RfD, however, it is similar to Aroclor-1254. Both are polychlorinated biphenyls (PCBs), so it is acceptable to compare the Aroclor-1260 exposure dose to those found in the literature for Aroclor-1254. The calculated exposure doses for Aroclor-1260 (0.000007 mg/kg/day for adults and 0.000023 mg/kg/day for children) were well below the levels found in the literature for less serious health effects (0.005 mg/kg/day) [ATSDR 1998].
When dealing with exposure to lead, ATSDR calculates what the cumulative blood lead level might be as a result of exposure to the level of contamination present. This is done by multiplying the detected concentration by a slope factor of 0.26 (for water) [ATSDR 1999]. Then ATSDR compares this expected blood lead level (0.007 micrograms per deciliter) to what the Centers for Disease Control considers to be an elevated level (10 micrograms per deciliter). In this case, the level of lead detected in the surface water is much too low to be of health concern.
In addition, the effluent from the groundwater pump and treat system was evaluated. One volatile organic compound (TCE) and one semi-volatile organic compound (naphthalene) were detected above CVs. The calculated exposure doses (TCE = 0.000001 mg/kg/day for adults and 0.000003 mg/kg/day for children; naphthalene = 0.00001 mg/kg/day for adults and 0.00004 mg/kg/day for children) were well below EPA's RfDs for these two contaminants (0.006 mg/kg/day for TCE and 0.02 mg/kg/day for naphthalene) and are; therefore, not at levels of health concern.
Soil
Only PCB-contaminated soil outside the perimeter fence was of concern due to potential past exposures. Since site access is restricted, exposure doses were not calculated for on-site contamination. Off-site surface soil was sampled by Prince George's County Health Department and Maryland Department of the Environment in 1986 and 1987. In order to estimate a probable exposure dose from occasionally playing in the area surrounding Brandywine DRMO, ATSDR calculated an average soil concentration. However, since the highest detection (105,387 ppm) was over one hundred times higher than the next highest concentration (855 ppm), this outlier was not used in the average soil calculation because it did not accurately represent overall off-site soil conditions. Rather, this concentration was evaluated separately as an acute exposure. The calculated exposure doses based on a chronic exposure to the soils outside of Brandywine DRMO were 0.0000565 mg/kg/day for adults and 0.000344 mg/kg/day for children which are below levels found in the literature for less serious health effects (0.005 mg/kg/day) and cancer effect levels (1.0 mg/kg/day) [ATSDR 1998]. The calculated exposure doses expected to result from acute exposure to soil with the highest detection were 0.15 mg/kg/day for adults and 0.92 mg/kg/day for children, which are also below the health effects levels seen in the literature for acute exposure (1.0 mg/kg/day).
Moreover, PCB concentrations in the soil showed a distinct pattern of decreasing concentrations farther away from the fence line. Soil samples taken at six feet from the fence line were below the 10 ppm action level. The exposure doses that were calculated assume that children only played within six feet of Brandywine DRMO. It is improbable that children restricted their play to that relatively small area immediately outside the site, rather in all likelihood, they played throughout the entire wooded area (in areas without PCB contamination) and only occasionally encountered contaminated soil within six feet of the fence. In addition, the dose estimates assume that children ingested 200 mg per day of contaminated soil. According to population studies, this is the average ingestion rate for children ages 1 to 3. Children 6 years or older consume a much lower amount of soil (23.4 mg/day), which would result in a lower exposure dose than what was estimated (EPA 1997).
One former Brandywine community member reported that he played (e.g., built forts) in the general area surrounding Brandywine DRMO from 1960 to 1972. Using the data from 1986 and 1987 ATSDR calculated a conservative exposure dose for his 12 years of exposure. His average 12-year exposure dose (0.0002 mg/kg/day) was below levels known to cause adverse health effects (0.005 mg/kg/day). Moreover, the highest exposure (0.0003 mg/kg/day) having occurred at the youngest age was also well below levels seen in the literature for less serious health effects (0.005 mg/kg/day).
Three cleanup actions have been accomplished to remediate the soils to concentrations below 10 ppm. No exposures of health concern are expected to occur after soil was remediated. Using 10 ppm as the maximum concentration, exposure doses for adults (0.00001 mg/kg/day) incidentally ingesting 100 mg of soil 365 days a year for 30 years and children (0.00009 mg/kg/day) incidentally ingesting 200 mg of soil 365 days a year for 6 years were well below levels seen in the literature for less serious health effects (0.005 mg/kg/day).
APPENDIX C: RESPONSES TO PUBLIC COMMENTS
ATSDR received the following comments during the public comment period (February 13 to March 25, 2001) for the Brandywine DRMO Public Health Assessment (February 2001). For comments that questioned the validity of statements made in the Public Health Assessment, ATSDR verified or corrected the statements. The list of comments does not include editorial comments concerning such things as word spelling or sentence syntax.
Response: ATSDR based its decisions on the best data that were available at the time. If not enough data existed upon which to make a public health decision, the pathway was determined to be indeterminate (as in the case of future exposure to contaminated groundwater and past exposure to inhalation of smoke). If necessary and requested, ATSDR can review any new data that are collected and analyzed (e.g., from the Remedial Investigation/Feasibility Study). If the new data suggest that further evaluation is warranted, then ATSDR can perform the appropriate follow-up activity.
Response: ATSDR confirmed with Andrews AFB personnel for a second time that the current groundwater treatment system installed at Brandywine DRMO is the one that is mentioned in the 1998 Decision Document for the Remediation of TCE-Contaminated Groundwater at Brandywine DRMO. However, Andrews AFB personnel did note that the document was never formally approved by the regulators. Therefore, the text has been modified to reflect that the treatment system was described rather than approved.
Response: Despite modeling in the 1998 Decision Document for the Remediation of TCE-Contaminated Groundwater at Brandywine DRMO that suggests that the current groundwater treatment system could recover a large amount of the plume, ATSDR voiced its concern on page 13 that any future public health hazards are dependent upon the effectiveness of the system. The text was adjusted to be more specific to removing VOCs from groundwater in the vicinity of the site. It is ATSDR's understanding that the scheduled Remedial Investigation/Feasibility Study will determine if additional remedial actions are needed.
For a response about the status of the two wells please read the response to comment 5.
Response: Modeling in the 1998 Decision Document for the Remediation of TCE-Contaminated Groundwater at Brandywine DRMO indicated that the groundwater treatment system would be effective in removing a large amount of the contamination. However, the US Environmental Protection Agency (EPA) and Prince George's County Health Department (PGCHD) disagree with the model results and the effectiveness of the treatment system. Therefore, to be protective of public health, ATSDR will not assume that the treatment system is effective until the system has been in operation long enough to generate data that confirm that the selected remedy is adequately reducing the extent and level of contamination in the groundwater.
Response: The full extent of the trichloroethylene (TCE) plume was characterized in 1991 (Dames & Moore 1992). The plume was defined only by its southern boundaries in 1997 and 1999 (IT Corporation 1997a, 1998b). Even though the northern boundary of the groundwater plume has not been adequately defined since 1991, ATSDR can still evaluate the potential exposure situations. ATSDR is specifically concerned with two groundwater wells (one on Cherry Tree Crossing Road and one on Missouri Avenue) that are currently being used to supply water to residents:
Both wells are located to the west of Brandywine DRMO, and southwest of the groundwater plume. The overall groundwater flow pattern is to the northwest; therefore, ATSDR does not expect the plume to migrate to where the wells are located. However, the groundwater flow pattern has been shown to vary with rainfall and there is the potential for the groundwater to move in a southwesterly direction. Because there is the potential for the plume to migrate towards the wells and no samples have been collected from the well on Missouri Avenue, ATSDR has adjusted the hazard category for drinking water from these two groundwater wells from "no current public health hazard" to "no apparent current public health hazard."
During the scheduled Remedial Investigation/Feasibility Study the plume's boundaries will again be defined and samples will be collected from these two private wells. If the data from this investigation suggests that the groundwater wells on Cherry Tree Crossing Road and Missouri Avenue are in danger of being impacted by the plume, ATSDR will re-evaluate the potential exposure from drinking water from these wells.
Response: ATSDR revised the text to reflect that the USGS well survey was not comprehensive. However, ATSDR is fairly certain, based on discussions with PGCHD and examinations of plume and parcel maps, that no other drinking water wells (other than the two already mentioned) exist near the plume. Please notify Andrews AFB of any other wells not already identified.
Response: ATSDR's conclusion was in reference to the community's concern about exposure to contamination in their shallow drinking water wells in the late 1980s. Therefore, data that is over 10 years old is appropriate for evaluating this concern. However, the second to last sentence in this paragraph did use the present tense, therefore, it was modified to be in the past tense.