Toxicological Profile for 1,1-DICHLOROETHENE
Title: Toxicological Profile for 1,1-DICHLOROETHENE
Subject of Planned Report: The ATSDR toxicological profile succinctly reviews the toxicologic, epidemiologic, and adverse health effects for the substance being described. It also summarizes environmental fate and transport mechanisms and the potential for human exposure.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.
Type of Dissemination: ISI
Timing of Review (including deferrals): individual
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment in 2019
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 3
Primary Disciplines or Expertise: Toxicology, Epidemiology, Environmental Fate & Transport, Environmental Health
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor |
| Organizational Affiliation(s) | Department of Biochemistry & Molecular Biology, Department of Pathology, University of Texas Medical Branch |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: molecular toxicology and systems biology; biomarker signatures and metabolomics; chemical-mediated liver injury and chemical-mediated autoimmunity.He has over 120 publications and 5 book chapters. https://www.ncbi.nlm.nih.gov/pubmed?term=Ansari%20GA%5BAuthor%5D&cmd=DetailsSearch |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor of Biochemistry, Tadashi Inagami Chair in Biochemistry |
| Organizational Affiliation(s) | Department of Biochemistry The Vanderbilt University School of Medicine |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: biochemistry, drug metabolism, mass spectrometry, mutation, pharmacology, polymorphism, spectroscopy, toxicology; chemistry and enzymology of bioactivation and detoxication of foreign compounds Experience: Mechanisms of activation and detoxication of chemical carcinogens and toxicants; characterization of enzymes involved in these processes; metabolism of carcinogens and drugs by cytochrome P450 enzymes, the bioactivation of halogenated hydrocarbons, and polymerase interactions with carcinogen-modified DNA. https://www.ncbi.nlm.nih.gov/pubmed?term=Guengerich%2C%20F%20Peter%5BFull%20Author%20Name%5D&cmd=DetailsSearch |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor Emeritus of Pharmacology & Toxicology |
| Organizational Affiliation(s) | Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: Basic toxicology and pharmacokinetic questions that impact assessments of risks of chemicals to human health; volatile organic chemicals (VOCs) and pesticides: low environmental exposures and cancer risk to humans; drug-chemical interactions; physiologically-based pharmacokinetic models, pyrethroid pesticides and children’s health. Experience: Dr. Bruckner is an environmental toxicologist whose research areas include development of in vitro testing systems for hepatorenal toxins, comparison of the relative pharmacokinetics and toxicity of inhaled and ingested organics, and investigation of the toxicity of halogenated hydrocarbons. Dr. Bruckner has served as consultant to state and federal agencies and to industry and as a member of expert panels for these groups. He serves on editorial boards of the Journal of Toxicology and Environmental Health, Toxicology, and Toxicology and Applied Pharmacology. https://www.ncbi.nlm.nih.gov/pubmed?term=Bruckner%2C%20James%20V%5BFull%20Author%20Name%5D&cmd=DetailsSearch |
| Recommended by Scientific/Professional Society or General Public | No |
Charge to Peer Reviewers
Peer Reviewers’ Comments
CDC/ATSDR’s Response to Reviewers’ Comments
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