Toxicological Profile for 1,1,2-Trichloroethane

Title: Toxicological Profile for 1,1,2-Trichloroethane.

Subject of Planned Report: The ATSDR toxicological profile succinctly reviews the toxicological and epidemiological literature to identify adverse health effects of the substance being described.  It also summarizes environmental fate and transport mechanisms and the potential for human exposure.  Sources of information include unpublished studies which also require simultaneous peer review.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): individual

Type of Review (panel, individual or alternative procedure): individual

Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment in 2019

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: Toxicology, Toxicological Pathology, Pharmacokinetic Modeling, Risk Assessment, Environmental Health.

[Note that this edition is only a partial update of the previous Toxicological Profile.  Updates focused on health effects in Chapters 2, 3, and 7.]

Reviewers Selected by (agency or designated outside organization):  CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. David C. Dorman
1. Ansari, G.A. Shakeel
Academic and Professional Credentials DVM, PhD, DABT, DABVT, ATS
Current Position Title Professor, Toxicology
Organizational Affiliation(s) North Carolina State University, Raleigh, NC
Areas of Expertise, Discipline, Relevant Experiences Veterinary Pathologist; Toxicological Pathologist; Respiratory Toxicology; Neurobiology; Pharmacology; Toxicology; Pharmacokinetics; Risk Assessment; expert on systematic reviews of animal toxicity studies; expert on upper respiratory tract exposures and effects including damage to olfactory epithelium.

Recommended by Scientific/Professional Society or General Public No
2. James V Bruckner
2. Guengerich, F. Peter
Academic and Professional Credentials PhD
Current Position Title Professor emeritus, Interdisciplinary Toxicology Program, Pharmaceutical & Biomedical Sciences, College of Pharmacy
Organizational Affiliation(s) University of Georgia, Athens, GA
Areas of Expertise, Discipline, Relevant
Toxicology; Pharmacokinetics including PBPK modeling; Toxicological expertise on similar small chlorinated VOCs 
Recommended by Scientific/Professional
Society or General Public
3. Ivan Rusyn
3. Hattis, Dale
Academic and Professional Credentials M.D., Ph.D.
Current Position Title Professor and Chair
Department of Veterinary Integrative Biosciences
College of Vet Medicine & Biomedical Sciences;
Director, Superfund Research Center
Organizational Affiliation(s) Texas A&M University; College Station, TX
Areas of Expertise, Discipline, Relevant
Toxicology; Hepatic toxicity; Risk Assessment; health effects of small chlorinated VOCs; Carcinogenesis

Recommended by Scientific/Professional
Society or General Public

Additional elements to be added to the public posting as they become available

Charge to Peer Reviewers
Peer Reviewers’ Comments
CDC/ATSDR’s Response to Reviewers’ Comments
The ISI/HISA Dissemination Itself

Page last reviewed: March 19, 2019