Toxicological Profile for Mirex and Chlordecone

Title: Toxicological Profile for Mirex and Chlordecone

Subject of Planned Report: Mirex and chlordecone are two separate synthetic insecticides that have similar chemical structures. Animal stidies show that mirex can be taken into the bloodstream when one breathes in cigarette smoke containing mirex or eats food contaminated with mirex. Animal studies have shown that eating mirex can cause harmful effects on the stomach, intestines, liver, kidneys, eyes, thyroid, nervous system, and reproductive system.The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): April 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment June 2019

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. Rogene F Henderson
1. Rogene FHenderson
Academic and Professional Credentials PhD
Current Position Title Senior Scientist Emeritus
Organizational Affiliation(s) Lovelace Respiratory Research Institute
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: toxicology, biochemistry, chemistry

Experience: Served on Special Study Sections of the National Institutes of Health and the Health Effects Institute to review grant proposals in the area of lung biochemistry. Developed in vivo screening tests for pulmonary toxicants based on analysis of bronchoalveolar washings for biomarkers of lung injury and repair. Research on the mechanisms by which pulmonary inflammation leads to repair or to chronic disease (fibrosis, emphysema). Research on the pharmacokinetics of inhaled xenobiotics (particularly vapors) and chemical-specific biomarkers of chemical exposure.

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2. Lucio Costa
2. Lucio Costa
Academic and Professional Credentials PharmD
Current Position Title Professor
Organizational Affiliation(s) Department of Environmental and Occupational
Health Sciences, School of Public Health, University of Washington
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: experimental pharmacology, neurotoxicology

Experience: Director, Neurotoxicology Research Core, NIEHS Center in Ecogenetics and Environmental Health, University of Washington. University of Washington Core faculty in Interdisciplinary Molecular and Cellular Biology Program, Environmental and Occupational Epidemiology Training Program, Environmental Pathology/Toxicology Training Program (Director of Neurotoxicology and Developmental Toxicology Core).

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3. Luc Multigner
3. Luc Multigner
Academic and Professional Credentials MD, Ph.D.
Current Position Title Research Director
Organizational Affiliation(s) Inserm U1085 – IRSET, Research Institute of Occupational and Environmental Health
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: epidemiology, reproduction, fertility, prostate cancer, hormone dependent cancers, prenatal and post-natal development, endocrine disruptors

Experience: Head of the Guadeloupe Site of Inserm U1085 – IRSET. Head of the Team: “Exposure Assessment And Epidemiological Research on Environment, Reproduction, and Development (3ERD),” Inserm U1085 – IRSET, Rennes, France.

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Page last reviewed: July 15, 2019