Toxicological Profile for Lead

Title: Toxicological Profile for Lead

Subject of Planned Report: The main target for lead toxicity is the nervous system. Lead exposure may also cause weakness in fingers, wrists, or ankles; small increases in blood pressure; anemia; brain and kidney damage; death; miscarriage; and damaged sperm production. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): January February 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment June 2019

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. Nelly Mañay
1. Nelly Mañay
Academic and Professional Credentials PhD
Current Position Title Full Professor of Toxicology Area – Faculty of Chemistry
Organizational Affiliation(s) University of the Republic of Uruguay
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: chemistry, environmental toxicology, pharmaceutical chemistry

Experience: Full Professor (Senior lecturer) of Toxicology, Faculty of Chemistry, University of the Republic of Uruguay (UdelaR). Areas of interest: environmental, analytical, forensic, regulatory. Director of the Toxicology Laboratory CEQUIMTOX (Specialized in Chemical Toxicology Centre). Research in Chemistry and Geosciences and National Agency for Research and Innovation (ANII) in Uruguay. Leads the analytical toxicology research group, research projects and advisory services in laboratory analysis. Research on environmental pollutants impacts on health as toxic metals and metalloids developing analytical methods for exposure biomarkers and population biomonitoring in surveillance projects. Toxicological research on environmental and analytical toxicology, toxic metals (methalloids) exposure, biological monitoring and health impacts in vulnerable Uruguayan populations. Research in Medical Geology and metal´s biomarkers.

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2. Howard Hu
2. Howard Hu
Academic and Professional Credentials MD, MPH, MS, ScD
Current Position Title Visiting Scholar; Affiliate Professor (beginning December, 2017)
Organizational Affiliation(s) Currently he is a Visiting Scholar at the University of Washington, Seattle, Washington, United States of America, Department of Occupational and Environmental Health Sciences, University of Washington School of Public Health, Seattle, WA. He is on sabbatical/administrative leave from the University of Toronto from July 1, 2017 to June 30, 2018 where his primary position is Dean of the Dalla Lana School of Public Health at the University of Toronto, Toronto, Ontario, Canada.
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: board certified in internal medicine and in occupational medicine

Experience: Founding Dean of the Dalla Lana School of Public Health at the University of Toronto, Toronto, Ontario, Canada. His major research interests are: 1. Environmental and molecular epidemiologic research on heavy metals. 2. Potential endocrine disruptors, other neurotoxicants, carcinogens. 3. Gene-environment interactions, epigenetic dysregulation. 4. Fetal/early life exposures and long-term effects. 5. Aging-environment interactions. 6. Environmental health, health inequities, health disparities, and human rights. 7. Health and the global environment. 8. “Big Data” for population health. 9. Environmental sensitivities/Multiple chemical sensitivities.

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3. Anthony L. Knafla
3. Anthony L. Knafla
Academic and Professional Credentials B.Sc., MSc.
Current Position Title Senior Scientist/Founder
Organizational Affiliation(s) Equilibrium Environmental Inc., Calgary, AB, Canada
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: toxicology, biochemistry

Experience: Toxicology, risk assessment, modelling, analytical techniques, risk management and remediation plan development, and remediation innovation. Human health and ecological risk assessments (toxicology, fate and transport modeling, kinetic modelling) on sources of environmental impact, including:

  1. hydrocarbons, salts and metalloids at upstream, midstream, and downstream oil and gas facilities;
  2. metals at nuclear weapon processing facilities;
  3. chlorinated organic compounds at pulp and paper facilities as well as former Alberta Environment Help End Landfill Pollution projects;
  4. chemical blends at chemical manufacturing plants;
  5. chemical warfare agents including chlorinated organics at Canadian test sites;
  6. chlorinated solvents at dry cleaner facilities;
  7. organic compounds at wood treatment facilities; and,
  8. organic and inorganic parameters associated with sewage processing infrastructure.

Board certified toxicologist (Diplomate of the American Board of Toxicology).

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Page last reviewed: July 15, 2019