Toxicological Profile for 1,2,3-Trichloropropane
Title: Toxicological Profile for 1,2,3-Trichloropropane
Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.
Type of Dissemination: ISI
Timing of Review (including deferrals): April 2018
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment June 2019
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 3
Primary Disciplines or Expertise: toxicology, environmental health, chemistry
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor and Director of EOHSI, Rutgers |
| Organizational Affiliation(s) | Rutgers School of Public Health Department of Environmental & Occupational Health Sciences Institute (EOHSI) and Director of the National Institute of Environmental Health Sciences (NIEHS) |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: toxicogenomics and functional genomics, carcinogenesis, molecular and cellular biology, toxicology; oncogene activation, mechanisms of signal transduction, and genetic linkage analysis. His studies in the area of toxicogenomics include the development and application of standards for DNA microarray experiments, and phenotypic anchoring of response of human cells, model organisms (yeast) and target organs (rodents) to toxicants, providing insights into dose and temporal responses, as well as mechanisms of action. He is also actively involved in technology development for functional genomics and biomarker screening. Experience: Dr. Zarbl serves as the Director of the NIEHS sponsored Center for Environmental Exposures and Disease. He is also the Associate Director For Public Health Sciences at the Cancer Institute of New Jersey. He serves on numerous national research review and advisory panels, and editorial panels. Dr. Zarbl is known for his work in areas of toxicogenomics, and mechanisms of and genetic susceptibility to chemical carcinogenesis, mechanisms of mutagenesis and toxicity, and technology development. These research efforts have to date resulted in over 70 scientific papers and book chapters. |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Research Professor |
| Organizational Affiliation(s) | George Perkins Marsh Institute, Clark University |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: pharmacokinetics, risk assessment, pharmacodynamics, toxicology, toxicity, pharmacokinetic modeling, pharmacogenetics, toxicokinetics, PKPD modeling, human health Experience: Bridge the gap between experimental scientists and statistical researchers by representing the causal mechanisms that are likely to lead to biological damage of policy interest. The principal foci of his past work are the use of various biomarkers and physiologically-based pharmacokinetic models to improve risk assessment for carcinogens; quantitative treatment of inter-individual variability in susceptibility for a wide variety of non-cancer effects; and the use of Monte Carlo simulations to represent the combined effects of multiple sources of uncertainty and variability. |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor |
| Organizational Affiliation(s) | Department of Biochemistry & Molecular Biology, Department of Pathology, University of Texas Medical Branch |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: molecular toxicology and systems biology; biomarker signatures and metabolomics; chemical-mediated liver injury and chemical-mediated autoimmunity. Experience: molecular toxicology, biomarker signatures, metabolomics, chemical – mediated autoimmunity, chemical – mediated liver injury, systems biology. He has over 120 publications and 5 book chapters. He also received many honors and awards. |
| Recommended by Scientific/Professional Society or General Public | No |
Peer Review Charge for 1,2,3-Trichloropropane Toxicological Profile – Draft for Public Comment
Peer Reviewers’ Comments and CDC/ATSDR’s Response to Reviewers’ Comments:
The ISI/HISA Dissemination Itself:
https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=912&tid=186