Toxicological Profile for 3,3’-Dichlorobenzidine

Title: Toxicological Profile for 3,3’-Dichlorobenzidine (DCBZ)

Subject of Planned Report: The ATSDR toxicological profile succinctly reviews the toxicologic and epidemiologic literature to identify adverse health effects for the substance being described. It also summarizes environmental fate and transport mechanisms and potential for human exposure.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): 1/13/2020

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment at the end of 2020 or beginning of 2021.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise:   Exposure assessment, toxicology, environmental and/or occupational health, organic chemistry, textiles engineering/chemistry

Reviewers Selected by (agency or designated outside organization):  CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. Harold Freeman
1. Dale, Hattis
Academic and Professional Credentials PhD
Current Position Title Professor
Organizational Affiliation(s) Polymer and Color Chemistry
Textile Engineering, Chemistry and Science
North Carolina State University
Areas of Expertise, Discipline, Relevant
Organic dyes and pigments; textile chemistry including pigments, dyes, and amines as related directly to the profile substances.
Recommended by Scientific/Professional
Society or General Public     
2. James V. Bruckner
2. Robert E. Oswald
Academic and Professional Credentials PhD
Current Position Title Professor, Emeritus
Organizational Affiliation(s) Department of Pharmaceutical and Biomedical Sciences
College of Pharmacy, University of Georgia
Athens, Georgia
Areas of Expertise, Discipline, Relevant Experiences Basic toxicology and pharmacokinetic questions that impact assessments of risks of chemicals to human health; volatile organic chemicals (VOCs) and pesticides: low dose environmental exposures and cancer risk to humans; drug-chemical interactions; physiologically-based pharmacokinetic models, pyrethroid pesticides, and children’s health.

Experience: Dr. Bruckner is an environmental toxicologist whose research areas include development of in vitro testing systems for hepatorenal toxins, comparison of the relative pharmacokinetics and toxicity of inhaled and ingested organics, and investigation of the toxicity of halogenated hydrocarbons.

Recommended by Scientific/Professional
Society or General Public
3. Kenneth Rosenman
3. Deziel, Nicole
Academic and Professional Credentials MD
Board Certified:
American Board of Internal Medicine
American Board of Preventive Medicine
Occupational and Environmental Medicine
Current Position Title Distinguished Professor
Chief, Division of Occupational and Environmental Medicine
Clinician at MSU Medicine Specialty Center, Occupational Medicine Clinic
Faculty, Institute for Integrative Toxicology
Organizational Affiliation(s) Michigan State University
Areas of Expertise, Discipline, Relevant Experiences Extensive publications regarding chemical exposures. Decades of clinical experience. Collaboration with state health department on occupational diseases and injuries.

Recommended by Scientific/Professional
Society or General Public     

Additional elements to be added to the public posting as they become available:

Charge to Peer Reviewers

CDC/ATSDR’s Response to Reviewers’ Comments: (under clearance)

The ISI/HISA Dissemination Itself: (to be released soon)

Page last reviewed: September 21, 2020