Toxicological Profile for 2-Butanone

Title: Toxicological Profile for 2-Butanone

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): May 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment June 2019

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. G.A. Shakeel Ansari
1. Ansari, G.A. Shakeel
Academic and Professional Credentials PhD
Current Position Title Professor
Organizational Affiliation(s) Department of Biochemistry & Molecular Biology, Department of Pathology, University of Texas Medical Branch
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: molecular toxicology and systems biology; biomarker signatures and metabolomics; chemical-mediated liver injury and chemical-mediated autoimmunity.
Experience: molecular toxicology, biomarker signatures, metabolomics, chemical – mediated autoimmunity, chemical – mediated liver injury, systems biology. He has over 120 publications and 5 book chapters. He also received many honours and awards.
Recommended by Scientific/Professional Society or General Public No
2. F. Peter Guengerich
2. Guengerich, F. Peter
Academic and Professional Credentials PhD
Current Position Title Professor of Biochemistry, Tadashi Inagami Chair in Biochemistry
Organizational Affiliation(s) Department of Biochemistry
The Vanderbilt University School of Medicine
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: biochemistry, drug metabolism, mass spectrometry, mutation, pharmacology, polymorphism, spectroscopy, toxicology; chemistry and enzymology of bioactivation and detoxication of foreign compounds
Experience: Mechanisms of activation and detoxication of chemical carcinogens and toxicants; characterization of enzymes involved in these processes; metabolism of carcinogens and drugs by cytochrome P450 enzymes, the bioactivation of halogenated hydrocarbons, and polymerase interactions with carcinogen-modified DNA.
Recommended by Scientific/Professional Society or General Public No
3. Dale Hattis
3. Hattis, Dale
Academic and Professional Credentials PhD
Current Position Title Research Professor
Organizational Affiliation(s) The George Perkins Marsh Institute
Clark University
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: pharmacokinetics, risk assessment, pharmacodynamics, toxicology, toxicity, pharmacokinetic modeling, pharmacogenetics, toxicokinetics, PKPD modeling, human health
Experience: Bridge the gap between experimental scientists and statistical researchers by representing the causal mechanisms that are likely to lead to biological damage of policy interest. The principal foci of his past work are the use of various biomarkers and physiologically-based pharmacokinetic models to improve risk assessment for carcinogens; quantitative treatment of inter-individual variability in susceptibility for a wide variety of non-cancer effects; and the use of Monte Carlo simulations to represent the combined effects of multiple sources of uncertainty and variability.
Recommended by Scientific/Professional Society or General Public No

Charge to Peer Reviewers: Charge to Peer Reviewers 2-Butanone

Peer Reviewers’ Comments and CDC/ATSDR’s Response to Reviewers’ Comments: DISPOSITION OF PEER REVIEW COMMENTS FOR TOXICOLOGICAL PROFILE FOR 2-BUTANONE pdf icon[PDF – 162 KB]

The ISI/HISA Dissemination Itself: https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=343&tid=60

Page last reviewed: July 10, 2019