Toxicological Profile for 2-Butanone
Title: Toxicological Profile for 2-Butanone
Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.
Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.
Type of Dissemination: ISI
Timing of Review (including deferrals): May 2018
Type of Review (panel, individual or alternative procedure): Individual
Opportunities for the Public to Comment (how and when): A draft of this profile was made available for public comment June 2019
Peer Reviewers Provided with Public Comments before the Review: No
Anticipated Number of Reviewers: 3
Primary Disciplines or Expertise: toxicology, environmental health, chemistry
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR
Public Nominations Requested for Reviewers: No
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor |
| Organizational Affiliation(s) | Department of Biochemistry & Molecular Biology, Department of Pathology, University of Texas Medical Branch |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: molecular toxicology and systems biology; biomarker signatures and metabolomics; chemical-mediated liver injury and chemical-mediated autoimmunity. Experience: molecular toxicology, biomarker signatures, metabolomics, chemical – mediated autoimmunity, chemical – mediated liver injury, systems biology. He has over 120 publications and 5 book chapters. He also received many honours and awards. |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Professor of Biochemistry, Tadashi Inagami Chair in Biochemistry |
| Organizational Affiliation(s) | Department of Biochemistry The Vanderbilt University School of Medicine |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: biochemistry, drug metabolism, mass spectrometry, mutation, pharmacology, polymorphism, spectroscopy, toxicology; chemistry and enzymology of bioactivation and detoxication of foreign compounds Experience: Mechanisms of activation and detoxication of chemical carcinogens and toxicants; characterization of enzymes involved in these processes; metabolism of carcinogens and drugs by cytochrome P450 enzymes, the bioactivation of halogenated hydrocarbons, and polymerase interactions with carcinogen-modified DNA. |
| Recommended by Scientific/Professional Society or General Public | No |
| Academic and Professional Credentials | PhD |
|---|---|
| Current Position Title | Research Professor |
| Organizational Affiliation(s) | The George Perkins Marsh Institute Clark University |
| Areas of Expertise, Discipline, Relevant Experiences | Expertise / Discipline: pharmacokinetics, risk assessment, pharmacodynamics, toxicology, toxicity, pharmacokinetic modeling, pharmacogenetics, toxicokinetics, PKPD modeling, human health Experience: Bridge the gap between experimental scientists and statistical researchers by representing the causal mechanisms that are likely to lead to biological damage of policy interest. The principal foci of his past work are the use of various biomarkers and physiologically-based pharmacokinetic models to improve risk assessment for carcinogens; quantitative treatment of inter-individual variability in susceptibility for a wide variety of non-cancer effects; and the use of Monte Carlo simulations to represent the combined effects of multiple sources of uncertainty and variability. |
| Recommended by Scientific/Professional Society or General Public | No |
Charge to Peer Reviewers: Charge to Peer Reviewers 2-Butanone
Peer Reviewers’ Comments and CDC/ATSDR’s Response to Reviewers’ Comments: DISPOSITION OF PEER REVIEW COMMENTS FOR TOXICOLOGICAL PROFILE FOR 2-BUTANONE [PDF – 162 KB]
The ISI/HISA Dissemination Itself: https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=343&tid=60