Toxicological Profile for N-nitrosodi-n-propylamine

Title: Toxicological Profile for N-nitrosodi-n-propylamine

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): April 2018

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment in 2019

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. Richard J. Bull
1. Richard J. Bull
Academic and Professional Credentials PhD
Current Position Title Toxicologist, Professor Emeritus, Pharmacology and Toxicology, Washington State University
Organizational Affiliation(s) MoBull Consulting and Washington State University
Richland, WA
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: pharmacology, toxicology, chemistry, water pollution
Experience: Dr. Bull is a former toxicologist / research pharmacologist at the US EPA Health Effects Research Laboratory, former chief for the Toxicological Assessment branch at US EPA; and a former Director, Toxicology and Microbiology Division, EPA. He was Professor and then Chair, Pharmacology/ Toxicology Program at Washington State University before becoming a Senior Staff Scientist at Battelle Pacific Northwest Laboratory. He has numerous awards, has been invited speaker and authors to close to a hundred publcaitions.
Recommended by Scientific/Professional
Society or General Public
No
2. Peter Guengerich
2. Peter Guengerich
Academic and Professional Credentials PhD
Current Position Title Professor of Biochemistry, Tadashi Inagami Chair in Biochemistry Professor
Organizational Affiliation(s) Department of Biochemistry
The Vanderbilt University School of Medicine
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: biochemistry, drug metabolism, mass spectrometry, mutation, pharmacology, polymorphism, spectroscopy, toxicology; chemistry and enzymology of bioactivation and detoxication of foreign compounds
Experience: Mechanisms of activation and detoxication of chemical carcinogens and toxicants; characterization of enzymes involved in these processes; metabolism of carcinogens and drugs by cytochrome P450 enzymes, the bioactivation of halogenated hydrocarbons, and polymerase interactions with carcinogen-modified DNA.
Recommended by Scientific/Professional
Society or General Public
No
3. James Bruckner
3. James Bruckner
Academic and Professional Credentials PhD
Current Position Title Professor of Pharmacology & Toxicology
Organizational Affiliation(s) Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia
Areas of Expertise, Discipline, Relevant Experiences Expertise / Discipline: Basic toxicology and pharmacokinetic questions that impact assessments of risks of chemicals to human health; volatile organic chemicals (VOCs) and pesticides: low environmental exposures and cancer risk to humans; drug-chemical interactions; physiologically-based pharmacokinetic models, pyrethroid pesticides and children’s health.
Experience: Dr. Bruckner is an environmental toxicologist whose research areas include development of in vitro testing systems for hepatorenal toxins, comparison of the relative pharmacokinetics and toxicity of inhaled and ingested organics, and investigation of the toxicity of halogenated hydrocarbons. Dr. Bruckner has served as consultant to state and federal agencies and to industry and as a member of expert panels for these groups. He serves on editorial boards of the Journal of Toxicology and Environmental Health, Toxicology, and Toxicology and Applied Pharmacology.
Recommended by Scientific/Professional
Society or General Public
No

Charge to Peer Reviewers: Charge to Peer Reviewers N-nitrosodi-n-propylamine

Additional elements to be added to the public posting as they become available

Page last reviewed: June 21, 2018