Toxicological Profile for 1,4-Dioxane

Title: Toxicological Profile for 1,4-Dioxane

Subject of planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): April 2010

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile was made available for a 90-day public comment period on October 23, 2007.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3 or fewer

Primary Disciplines or Expertise: toxicology, environmental health, chemistry
Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Charge to Peer Reviewers: DTEM Charge to Peer Reviewers

Peer Reviewers:

1. George Alexeeff
1. Alexeeff, George
Academic and Professional Credentials: Ph.D. in Pharmacology and Toxicology, University of California at Davis
B.A. in Chemistry, Swarthmore College, Swarthmore, PA
Current Position Title: Deputy Director for Scientific Affairs, Office of Environmental Health Hazard Assessment
Organizational Affiliation(s) California Environmental Protection Agency
Areas of Expertise, Discipline, Relevant Experiences Dr. Alexeeff oversees a staff of over 80 scientists (including physicians, toxicologists, and epidemiologists) in multidisciplinary evaluations of the health impact of pollutants and toxicants in air, water, soil and other media. Areas include: identification of carcinogens and reproductive toxins in the environment, through the evaluation of human and animal data as well as indicators of special susceptibility; review of epidemiological and toxicological data to identify hazards and derive risk-based assessments; development of guidelines to identify chemicals hazardous to the public and compounds to which infants and children may have increased susceptibility; recommending ambient air quality standards for California; identifying toxic air contaminants; characterizing air toxics hot spots; developing public health goals for contaminants in water; preparing Proposition 65 evaluations for carcinogens and developmental/reproductive toxins; issuing sport fish consumption advisories to the public; conducting epidemiological studies or investigations, developing indicators of environmental quality; pesticide poisoning illness surveillance, training health personnel on pesticide poisoning recognition; reviewing hazardous waste site risk assessments; and conducting multi-media risk assessments. He has reviewed over 140 documents evaluating human epidemiological or animal toxicological evidence for the Office of Environmental Health Hazard Assessment or other agencies such as U.S. EPA. Dr. Alexeeff is also an Associate Adjunct Professor in the Department of Environmental Toxicology at the University of California, Davis.
Recommended by Scientific/Professional Society or General Public No
2. A. Leber
2. Leber, A.
Academic and Professional Credentials: Ph.D., M.S., Pharmacology/Toxicology, Purdue University
B.S., Chemistry, University of California, Davis
Current Position Title: Consultant in toxicology
Organizational Affiliation(s) Member, American Board of Toxicology
Society of Toxicology and its regional chapter
International Society of Regulatory Toxicology/Pharmacology
American Chemical Society and its regional chapter
Areas of Expertise, Discipline, Relevant Experiences Dr. Leber has been a toxicology consultant since 1988, in which capacity he has served, most recently, as senior toxicologist and project manager for Goodyear Tire and Rubber. Dr. Leber is an expert in the toxicology of volatile organics and pesticides. Dr. Leber has assisted in the development and expert review of EPA Drinking Water Advisories. He has performed health assessments for chemicals found in environmental settings (air, water, soil), underground tanks, and in the workplace; calculated chemical levels deemed safe for various exposure media; provided toxicological expertise and comments addressing development of Indoor Air Quality (IAQ) standards under consideration by OSHA. He has also participated in assessment of IAQ in residential and occupational-setting projects. Dr. Leber assisted law firms in approximately 20 cases as an expert witness in toxic tort actions involving alleged personal injuries from chemical agents (pesticides, solvents, corrosives, heavy metals, combustion products) found in occupational and non-occupational environments. Issues in these cases included cancer causation, lung, eye, and dermal injuries, and neurological and kidney lesions. He has authored and coauthored dozens of scientific journal articles and book chapters, and has given over 25 invited lectures to scientific groups and symposia all over the world. Dr. Leber has peer reviewed ATSDR’s toxicological profiles on nickel, pentachlorophenol, phosgene, 1,4-dioxane, 3,3-dichlorobenzidine, benzene, chlordane, ethylene glycol and propylene glycol, and ethylene oxide.
Recommended by Scientific/Professional Society or General Public No
3. Raghubir Sharma
3. Sharma, Raghubir
Academic and Professional Credentials: Post Doctoral Fellow, University of Minnesota
Ph.D. (Pharmacology), Minor Biochemistry, University of Minnesota
D.V.M. (B.V.Sc.), University of Rajasthan, India
Certified Industrial Hygienist
Current Position Title: Fred C. Davison Distinguished Chair in Toxicology, College of Veterinary Medicine, Department of Physiology and Pharmacology, University of Georgia, Athens
Organizational Affiliation(s) Fellow of American College of Veterinary Toxicologists
Member, Society of Toxicology
American Society for Pharmacology and Experimental Therapeutics
American Veterinary Medical Association
American Association for the Advancement of Science
New York Academy of Sciences
International Society for Biochemical Pharmacology
Society for Geochemistry and Health
The Society of Sigma Xi
American Industrial Hygiene Association
American Academy of Industrial Hygiene
Phi Zeta, the National Honor Society
Areas of Expertise, Discipline, Relevant Experiences Dr. Sharma is one of the foremost pharmacological and environmental toxicologists in the U.S. His current duties include research in toxicology, in which his primary areas of interest are pesticides and the health effects of environmental pollutants, and teaching professional veterinary students and graduate students. He is also Graduate Coordinator of the interdisciplinary graduate program in toxicology. Dr. Sharma has been on the editorial board of several professional journals, including: Fundamental and Applied Toxicology; Environmental Toxicology and Chemistry; Journal of Environmental Pathology and Toxicology; Toxicology and Industrial Health; and is currently on the board of the European Journal of Pharmacology (Environmental Toxicology and Pharmacology Section); and Environmental Toxicology and Pharmacology; and is assistant editor for Poisindex. He has also peer reviewed articles and submissions for over a dozen professional scientific journals, including; Toxicology and Applied Pharmacology; Pesticide Biochemistry and Physiology; Toxicological Sciences; Journal of Agricultural and Food Chemistr; International Immunopharmacology; Biomedical and Environmental Sciences; Archives of Environmental Contamination and Toxicology; and the European Journal of Pharmacology. He has edited 4 seminal books, two on immunological toxicology, one on mycotoxins and phytoalexins and one titled “Dietary Factors and Birth Defects,” has authored and coauthored over 40 chapters in scientific books, and published over 260 research articles in scientific journals. Dr. Aharma has served as a peer reviewer for ATSDR’s toxicological profiles on 1,4-dioxane, aldrin/dieldrin, fluorides, fluorine, hexachlorocyclohexanes, hydrazines, hydrogen fluoride (MMG), selenium, and tungsten.
Recommended by Scientific/Professional Society or General Public No

Peer Reviewers’ Comments: Dioxane Summary ReportCdc-pdfpdf icon [PDF – 706 KB]

CDC/ATSDR’s Response to Reviewers’ Comments: Dioxane Formal DispositionCdc-pdfpdf icon [PDF – 18 KB]

The ISI/HISA Dissemination Itself

Page last reviewed: August 18, 2015